Solitary splenic metastasis of ovarian carcinoma: Report of two cases

Alloni, Rossana; Garberini, A; Caputo, Damiano; Coppola, Roberto

doi:10.1007/s00595-007-3747-6

Cited by 18 publications

(17 citation statements)

References 21 publications

(34 reference statements)

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“…Among isolated splenic metastasis, isolated splenic parenchymal lesions are more infrequent and represent the hematogenous spreading of the malignancy. 10,17,18 Chen et al, 20 in 2000, evaluated the role of splenectomy at the time of surgical cytoreduction in advanced ovarian cancer and concluded that it could be performed with acceptable morbidity. More authors in more recent years suggest to incorporate upper abdominal resection in advanced ovarian cancer to achieve a complete cytoreduction.…”

Section: Discussionmentioning

confidence: 99%

Splenectomy as Part of Primary Cytoreductive Surgery for Advanced Ovarian Cancer: A Retrospective Cohort Study

Zapardiel

Peiretti

Zanagnolo

et al. 2012

Int J Gynecol Cancer

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Section: Discussionmentioning

confidence: 99%

Splenectomy as Part of Primary Cytoreductive Surgery for Advanced Ovarian Cancer: A Retrospective Cohort Study

Zapardiel

Peiretti

Zanagnolo

et al. 2012

Int J Gynecol Cancer

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“…The occurrence of ovarian clear cell carcinoma (OCCA) is relatively infrequent, accounting for 5% of all ovarian malignancies and 3.7–12.1% of all epithelial ovarian carcinomas (5–7). As reported previously, OCCA has a distinct histological type with poor prognosis and resistance to platinum-based chemotherapy (7,14). The majority of patients with advanced or recurrent OCCA have a low benefit-to-failure ratio from palliative chemotherapy (7).…”

Section: Introductionmentioning

confidence: 60%

Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature

Luo

et al. 2014

Experimental and Therapeutic Medicine

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Splenic metastasis of ovarian cancer appears to be more common in serous cystadenocarcinomas. Splenic metastasis usually occurs postoperatively and simultaneously with dissemination to the greater omentum and pelvic cavity. Compared with other ovarian cancer subtypes, ovarian clear cell adenocarcinoma (OCCA) is rare, accounting for <5% of all ovarian malignancies. OCCA has a distinct histological type with poor prognosis and resistance to platinum-based chemotherapy. In the present study, a case of isolated splenic metastasis of OCCA was reported. A 53-year-old female presented with a mass in the left upper quadrant without any other clinical manifestations. Subsequent abdominal and pelvic computed tomography scans revealed multiple mixed cystic-solid lesions, potentially predicting ovarian malignancy. Pathological tests following ovarian cytoreductive surgery revealed primary OCCA with metastases to the spleen. The current study also reviewed recently published literature on splenic metastasis of ovarian carcinoma and demonstrated that the reported case was a rare case of isolated splenic metastasis of OCCA.

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“…Most cases of solitary splenic metastasis documented in the literature were diagnosed with stage III disease (FIGO classification), and underwent optimal tumor debulking [10]. The histological finding of the case described here was high-grade carcinoma consistent with metastatic endometrioid-type ovarian carcinoma, grade 3, stage 1A (FIGO classification).…”

Section: Discussionmentioning

confidence: 88%

Solitary splenic metastasis of ovarian carcinoma: a case report

2014

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IntroductionSplenic metastasis from ovarian carcinoma generally presents as peritoneal spread with multiorgan involvement. Fewer than 30 cases of solitary parenchymal splenic metastasis from ovarian carcinoma have been published in the literature. The presentation is often asymptomatic.Case presentationAn increase in tumor marker CA-125 from 18.1 to 132.6 units/ml (normal <35 units/ml) was measured in a 56-year-old Israeli Jewish woman who had undergone, six years previously, a total abdominal hysterectomy with bilateral salpingo-oophorectomy due to right ovarian carcinoma. An abdominal computed tomography scan revealed a mass of 6×8cm at the anterior of the spleen, with close proximity to the wall of the stomach. A gastroscopy demonstrated exterior pressure on the stomach body. An open splenectomy was performed to exclude a peritoneal carcinomatosis. No intraoperative evidence of tumoral spreading in the abdominal cavity was observed, other than the spleen. The final histologic result demonstrated a high-grade carcinoma consistent with metastatic endometrioid-type ovarian carcinoma grade 3.ConclusionsThis case highlights the importance of cancer antigen 125 assessment and medical imaging in the follow-up of ovarian carcinoma. Open laparotomy, or laparoscopy, enables exclusion of a peritoneal carcinomatosis, which is more common than solitary parenchymal splenic metastasis, as was presented in the current case.

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Solitary splenic metastasis of ovarian carcinoma: Report of two cases

Cited by 18 publications

References 21 publications

Splenectomy as Part of Primary Cytoreductive Surgery for Advanced Ovarian Cancer: A Retrospective Cohort Study

Splenectomy as Part of Primary Cytoreductive Surgery for Advanced Ovarian Cancer: A Retrospective Cohort Study

Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature

Solitary splenic metastasis of ovarian carcinoma: a case report

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