Solitary Splenic Metastasis from Colon Carcinoma.

Ohki, Satoshi T.; Kakinuma, Shinichi; Kusaba, Teruo; Ohwada, Susumu; Morishita, Yasuo

doi:10.5833/jjgs.27.2609

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“…A total of 26 such patients have been reported in the literature: 6 in the English-language literature (Medline version 7.0.5; Ovid Technologies, NY, USA), [7][8][9][10][11][12] 19 in the Japanese literature (Igaku Chuo Zasshi; Japan Medical Abstracts Society, Tokyo, Japan), [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] and another case 31 in the reference list of the article by Mori et al 28 Two of the 26 cases were excluded because the patients' outcomes after splenectomy were not recorded in the reports. 12,30 The remaining 24 cases were included in this study.…”

Section: Methodsmentioning

confidence: 99%

“…Staging according to modified Dukes categories; 36 CEA, serum carcinoembryonic antigen level just before splenectomy; A, ascending colon; S, sigmoid colon; R, rectum; Adeno, adenocarcinoma; HEP, hepatic; PUL, pulmonary; PER, peritoneum; NED, (alive with) no evidence of disease; DOD, died of disease; AWD, alive with disease a Survival data in these patients were reviewed by Ohki et al17 and documented in their article…”

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confidence: 99%

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Clinical significance of splenectomy for colorectal cancer metastases to the spleen

Fujita

Shirai

Shimoda

et al. 2000

International Journal of Clinical Oncology

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Background. The value of splenectomy for secondary splenic tumors remains unclear. The aim of this study was to disclose the clinical significance of splenectomy for colorectal cancer metastases to the spleen by reviewing our two patients and the 24 other patients reported thus far. Methods. We report two patients with splenic metastasis from colonic cancer. A review of 26 cases, including ours, was conducted. Results. One of our patients had isolated splenic metastasis and is alive with no evidence of disease 14 months after splenectomy, while the other had non-isolated splenic metastasis and died of disseminated disease 17 months after splenectomy. In the 26 patients overall, the outcome of those with isolated splenic metastasis (n ϭ 20) was significantly better than that for those with non-isolated splenic metastasis (n ϭ 6; P ϭ 0.05). There were three long-term (more than 3 years) survivors; all three were patients with isolated splenic metastasis, with the longest survival being 110 months. Patients with mucinous carcinoma showed a better survival rate than patients with other histological types (P ϭ 0.08). In patients with isolated metastasis, metastases after splenectomy occurred in the peritoneum (n ϭ 3), liver (n ϭ 1), and lung (n ϭ 1) within 2 years. Conclusions. Splenectomy may provide long-term survival for patients with isolated colorectal cancer metastasis to the spleen. The mucinous variant may be a favorable prognostic factor after splenectomy. Recurrence after splenectomy is likely to occur within 2 years, mainly in the peritoneum.

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