Solitary Pancreatic Metastasis of Renal Cell Cancer Treated by Pancreaticoduodenectomy: A Case Report

Ee, Piccinini; Ugolini, Giampaolo; Rosati, Giancarlo; Nc, Salfi; Marroccu, S; M, Del Governatore; Conti, Alessandro

doi:10.1177/107327489600300510

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…In fact, half the lymphomas were misdiagnosed as a primary carcinoma. This is attributable to the fact that both lymphomas and renal cell carcinomas often formed solitary masses in the pancreas [1,3,7,8,18,19,24,57,70,71,92], with no obvious evidence of metastasis in other organs. Pancreatic metastases from colorectal carcinomas were also previously noted to mimic primary neoplasms, although this was not the case in our experience.…”

Section: Discussionmentioning

confidence: 94%

Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature

et al. 2004

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The vast majority of pancreatic carcinomas are primary, and, among these, more than 90% are of ductal origin. However, a variety of extrapancreatic tumors may involve the pancreas secondarily and may manifest different clinicopathological characteristics and outcomes. In this study, pathology material from 973 surgical specimens and 4955 adult autopsy cases was reviewed to identify the tumors metastatic to or secondarily involving the pancreas. Biliary and periampullary neoplasms and tumors confined to peripancreatic soft tissue were excluded. In the autopsy series, the pancreas was involved by tumor in 190 cases, and 81 of these were secondary tumors. These were predominantly of epithelial origin, most commonly from lung (34), followed by GI tract (20), kidney (4), breast (3), liver (2), ovary (1), and urinary bladder (1). In addition, there were six tumors of hematopoietic origin, two melanomas, two sarcomas, and two mesotheliomas. Among the 973 surgical specimens, 38 cases contained metastatic tumors to the pancreas. Of these, 11 were lymphomas, and the others were carcinomas of stomach (7), kidney (6), lung (2), liver, prostate, ovary, uterus (1 case of each), and a Merkel cell carcinoma. In addition, there were three malignant gastrointestinal stromal tumors and one retroperitoneal leiomyosarcoma. In conclusion, lung cancer is the most common source of metastasis to pancreas, followed by gastrointestinal carcinomas and lymphomas. These tumors are usually seen in patients with disseminated disease and are detected mainly in autopsies. Secondary tumors constitute about 4% of pancreatic specimens in the authors' surgical database. Approximately one-third of them are clinically mistaken as primary tumors of the pancreas. These are predominantly hematopoietic malignancies or carcinomas of renal or gastric origin. Secondary tumors should be entertained in both the clinical and pathological differential diagnosis of pancreatic neoplasia.

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Section: Discussionmentioning

confidence: 94%

Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature

et al. 2004

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“…Secondly, the incidence of lymph node metastasis reported for resected RCC metastases of the pancreas was extremely rare, indicating no requirement for radical lymph node dissection [5,6]. The review of the literature found that only two cases (4.5%) had peripancreatic lymph node metastasis after PD [17,32], and the other 42 reported cases had no metastasis to regional lymph node around the pancreas. Thirdly, the patients with RCC often have longterm survival after appropriate treatment, as observed in this case, placing greater importance on QOL after surgery.…”

Section: Discussionmentioning

confidence: 97%

Duodenum-preserving pancreatic head resection for pancreatic metastasis from renal cell carcinoma: a case report

Maeda

Okabayashi

Nishimori

et al. 2007

Langenbecks Arch Surg

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Renal cell carcinoma with metastasis to the pancreas: a case report and literature review

et al. 2004

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Nierenzellkarzinommetastasen. Die Inzidenz wird mit 1-3 % angegeben. Typisch ist ein langes Zeitintervall zwischen Primärtumor und Metastasierung.Methodik: Wir berichten über einen 52-jährigen Patienten, in dem die Metastasierung in das Pankreas acht Jahre nach Tumornephrektomie auftrat.Ergebnisse: Eine Pankreaslinksresektion mit Splenektomie wurde durchgeführt. Der operative und postoperative Verlauf waren komplikationslos. Die Histologie zeigte eine Metastase nach Nierenzellkarzinom.Schlussfolgerungen: Die effektivste Behandlung ist die radikale chirurgische Therapie. Die Prognose ist besser als bei primären Pankreasneoplasien. Da das Metastasierungsintervall lange ist und die Patienten oft asymptomatisch sind, ergibt sich die Notwendigkeit einer langfristigen und sorgfältigen Nachbeobachtung.Schlüsselwörter: Nierenzellkarzinom, Nieren, Metastasen, Pankreas.Summary. Background: The pancreas is a rare site for renal cell carcinoma (RCC) metastases, which tend to develop many years after the primary tumor has been diagnosed and treated. An incidence of 1-3% has been reported.Methods: We report a 52-year-old patient whose metastases to the pancreas were discovered by chance 8 years after tumor nephrectomy.Results: After a pancreas left resection and splenectomy, histology demonstrated a renal cell carcinoma.Conclusions: Careful long-term follow-up is essential due to late development (8 years) of these metastases, and when they occur, radical surgery is of great importance for the prognosis.

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Solitary Pancreatic Metastasis of Renal Cell Cancer Treated by Pancreaticoduodenectomy: A Case Report

Cited by 3 publications

References 5 publications

Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature

Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature

Duodenum-preserving pancreatic head resection for pancreatic metastasis from renal cell carcinoma: a case report

Renal cell carcinoma with metastasis to the pancreas: a case report and literature review

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