Solitary orbital myofibroma in a child: A rare case report with literature review

Abstract

Myofibroma is a rare benign mesenchymal tumor of uncertain histogenesis. A six-year-old boy presented with a unilateral lower eyelid mass of six weeks’ duration. MRI revealed a circumscribed mass in the inferolateral orbit with bony erosion. A systemic examination was unremarkable. Excision with histopathology revealed a partially infiltrative spindle cell tumor with bland nuclear morphology expressing smooth muscle actin and muscle-specific actin, compatible with myofibroma. Solitary myofibroma is a rare childhood orbital tumor and may clinico-radiologically closely mimic a malignancy. Histopathology and immunohistochemistry can help reach a definitive diagnosis. Systemic evaluation and close follow up are crucial in such cases.

Non-familial paediatric oral myofibroma - A masquerade. Case report with a brief literature review

“…Although a majority of myofibroma cases are common in infants, a few cases have been noted in older children and adults as well. [ 9 ] The present case is of solitary myofibroma in a 7-year-old child on the gingivobuccal sulcus. Most of the cases of the myofibroma are seen in males, with the Male: Female ratio being 2:1, and more commonly, the intra-oral myofibromas are seen on the tongue, buccal mucosa, and lips.…”

“…Since the lesion did not show features of nuclear atypia, abnormal mitosis, and mitotic figures, fibrosarcoma was ruled out. [ 3 6 7 8 9 10 ] The differential diagnosis with a panel of immunohistochemical markers used for identifying the nature of neoplastic cells in spindle cell lesions has been summarised in [ Table 1 ]. [ 3 6 7 8 9 10 ]…”

“…[ 3 6 7 8 9 10 ] The differential diagnosis with a panel of immunohistochemical markers used for identifying the nature of neoplastic cells in spindle cell lesions has been summarised in [ Table 1 ]. [ 3 6 7 8 9 10 ]…”

Infantile Myofibroma of the Frontal Bone: A Case Report

“…[1][2][3] The reported incidence varies between 1 in 150 000 and 400 000. 4 Despite its rarity, it is considered the most common fibrous neoplasm in pediatric age group. 1,2,4 It commonly occurs in early childhood, with 90% of the cases occurring before 2 years of age.…”

“…4 Despite its rarity, it is considered the most common fibrous neoplasm in pediatric age group. 1,2,4 It commonly occurs in early childhood, with 90% of the cases occurring before 2 years of age. 2,4,5 Clinically, myofibroma lesions are classified into solitary and multicentric forms, designated as myofibroma and myofibromatosis respectively.…”