Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity

Argyris, Prokopios P.; Slama, Zachary M.; Nelson, Andrew C.; Koutlas, Ioannis G.

doi:10.1016/j.oooo.2019.03.016

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…While the direct causative link between HPV infection and skin cancer, particularly squamous cell carcinoma, is less clear and warrants further investigation, the existing literature underscores the potential for HPV to contribute to skin carcinogenesis through similar genomic and immunological pathways observed in other HPV-related malignancies. Targeted therapeutic strategies, including vaccination and immunotherapy, hold promise for the prevention and treatment of HPV-associated cancers, including potential implications for skin cancer management [33,[90][91][92][93] (See Supplementary Materials).…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus-Associated Giant Clear Cell Acanthoma and Squamous Cell Carcinoma: A Rare Case Report and Literature Review

Cuomo,

Rozen,

Pentangelo

et al. 2024

JCM

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Clear cell acanthoma (CCA) and squamous cell carcinoma (SCC) represent distinct entities within dermatological oncology, each posing unique diagnostic and therapeutic challenges. CCA is a rare, benign epidermal growth, often not associated with human papillomavirus (HPV) infection, whereas SCC, a more aggressive form of skin cancer, has been linked to both ultraviolet (UV) exposure and HPV. Understanding the co-occurrence of these conditions in a single patient can enhance diagnostic accuracy and therapeutic outcomes. We report a 64-year-old male who underwent an operation for a verruciform lesion in the right groin, which was diagnosed as HPV-positive CCA alongside keratinised SCC. A literature search across January 2024 revealed limited evidence directly linking HPV to CCA, suggesting a need for further investigation. The speculative association between HPV and CCA warrants deeper exploration, especially considering the potential for HPV to contribute to lesion development through indirect mechanisms. The coexistence of CCA and SCC in an elderly patient presents a unique clinical scenario. This emphasises the need for vigilant diagnosis and tailored treatment strategies, highlighting the gap in understanding the pathogenesis of CCA, particularly its potential association with HPV. Further research is crucial for elucidating the complex interactions governing these conditions and for developing targeted interventions.

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Section: Discussionmentioning

confidence: 99%

Human Papillomavirus-Associated Giant Clear Cell Acanthoma and Squamous Cell Carcinoma: A Rare Case Report and Literature Review

Cuomo,

Rozen,

Pentangelo

et al. 2024

JCM

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Oral verruciform hyperkeratotic lesions indicating the presence of plantar or palmoplantar keratodermas

Koutlas

Argyris

2022

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Oral Squamous Acanthoma – A Histopathologic Entity Or Not

Thamilselvan

2024

IJHI

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Oral squamous acanthoma (OSA) is an uncommon benign epithelial lesion of the oral cavity, presenting as a solitary, painless, sessile or pedunculated mass. It is considered a variant of oral squamous papilloma, characterized by acanthosis without papillomatosis. Although typically asymptomatic, OSA can cause discomfort or functional impairment depending on its size and location. Diagnosis is primarily based on clinical and histopathological examination, with characteristic features including hyperkeratosis, acanthosis, and elongated rete ridges. Treatment involves conservative surgical excision, with a low recurrence rate reported in the literature. Here, we present a rare case of OSA in a 55-year-old female patient, highlighting its clinical and histopathological characteristics, differential diagnosis, and management. This case underscores the importance of considering OSA in the differential diagnosis of oral lesions and the significance of histopathological analysis in confirming the diagnosis.

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Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity

Cited by 3 publications

References 33 publications

Human Papillomavirus-Associated Giant Clear Cell Acanthoma and Squamous Cell Carcinoma: A Rare Case Report and Literature Review

Human Papillomavirus-Associated Giant Clear Cell Acanthoma and Squamous Cell Carcinoma: A Rare Case Report and Literature Review

Oral verruciform hyperkeratotic lesions indicating the presence of plantar or palmoplantar keratodermas

Oral Squamous Acanthoma – A Histopathologic Entity Or Not

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