Solitary Myeloma of the Spine

Valderrama, J. A. Fernandez de; Bullough, Peter G.

doi:10.1302/0301-620x.50b1.82

Cited by 36 publications

(6 citation statements)

References 2 publications

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“…The rapid evolution of solitary plasmacytoma into multiple myeloma was infrequent in this series in comparison with other reports in the literature. They cite No. 8 PLASMACYTOMA OF THE SPINE -Delauche-Cavallier et al 1713 that up to 20% of solitary plasmacytoma of spine evolves into multiple myeloma within I year, probably because the cases were understaged at the time of diagnosis2 However, in this series the evaluable patients with multiple bone involvement that developed in the first few years after the diagnosis of solitary plasmacytoma had a fairly long survival, up to 10 years in one instance.…”

Section: Discussionsupporting

confidence: 81%

Solitary plasmacytoma of the spine. Long-term clinical course

Delauche–Cavallier

Laredo

Wybier

et al. 1988

Cancer

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The data for 19 patients with solitary plasmacytoma of the spine were reviewed with regard to clinical course and prognosis (median follow-up, 96 months). Eight patients presented with spinal cord compression. A monoclonal immunoglobulin was initially detected in seven of 15 evaluable patients. Treatment included radiotherapy (18 of 19) and/or surgery (11 of 19) and chemotherapy (eight of 19). Spinal cord compression was reversed in every patient. The expected survival rate was 85% at 10 years after diagnosis. Local recurrence or dissemination was observed in 13 patients. It occurred within 5 years of diagnosis in 11 patients and was localized (that is, local recurrence or single bone metastasis) in eight patients. It was always associated with the appearance or an increase of the M component. Dissemination frequently had a "metastatic" pattern with no diffuse bone marrow plasmacytosis. The incidence of local recurrence (five patients) and leukemia (four patients) was high. Local recurrence and/or dissemination were significantly more frequent in patients with the M component at diagnosis than in those without it (P less than 0.05; relative risk, R = 4). The effectiveness of surgery and chemotherapy combined with radiotherapy is also discussed.

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Section: Discussionsupporting

confidence: 81%

Solitary plasmacytoma of the spine. Long-term clinical course

Delauche–Cavallier

Laredo

Wybier

et al. 1988

Cancer

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“…This survival is indistinguishable from other patients with myeloma seen and treated at our in stitution during the same period of time, and from the published survival data for other patients with this disease [19,23]. Similarly, 94 patients reported from the Mayo Clinic with cord compression from malig nant lymphoma had a median survival of 27 months, and 40% survived 5 years [24], Thus survival is clearly more dependent upon the underlying disease than on the presence of cord compression, and long-term sur vival after cord compression from myeloma (or lym phoma) is not uncommon [11,14,15,17,25], Despite the prolonged survival, residual neurologic deficit can be expected. All 5 of our patients with persistent neurologic dysfunction developed one or more related complications and required hospitaliza tion for treatment.…”

Section: Discussionmentioning

confidence: 89%

Multiple Myeloma Presenting with Spinal Cord Compression

Spiess

Adelstein

Hines³

1988

Oncology

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The clinical features, treatment, and course of 6 patients with multiple myeloma, who presented initially with spinal cord compression, are reviewed. These 6 represent 12% of all patients with myeloma seen at our institution since 1979. Eighty-three similar patients were identified from the medical literature. There are no patient characteristics predictive for this presentation. A higher than expected proportion of patents have clinically localized disease, but progression to myelomatosis is common. As these patients present without a known diagnosis of malignancy, a prompt, invasive diagnostic procedure and the immediate institution of definitive local therapy is mandatory. Despite such an aggressive approach, the prospect for significant return of neurologic function is poor. Survival does not appear to be different from that of other patients with myeloma. Unlike other malignancies, a presentation with cord compression is not inconsistent with long-term survival, although significant morbidity secondary to the resultant functional disability can be expected.

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“…However CT guided FNAC in our case proved the solitary vertebral collapse was due to plasmacytoma. The first case of solitary plasmacytoma of spine was reported by Shaw in 1923 3 .They are very rare precursor lesions for multiple myeloma. Solitary myeloma is a focal malignant proliferation of plasma cells with no evidence of diffuse marrow involvement.…”

Section: Discussionmentioning

confidence: 99%

Solitary vertebral plasmacytoma causing compression fracture in a patient with multiple vertebral hemangiomas: a diagnosis easily missed!

2011

Orthop Rev

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The imaging mimics, acute osteoporotic compression fractures, metastasis and malignant melanoma or plasmacytoma pathological fractures are the important clinical problems in geriatric age group that need to be differentiated due to their grossly differing prognostic and therapeutic implications. There are few suggestive features on magnetic resonance imaging (MRI) that help differentiate between these entities. Hemangiomas are very common benign spinal tumors that have characteristic features on MRI. In the setting of multiple vertebral hemangiomas causing cord compression in elderly patients, the scenario is even more complex with four different entities with different prognostic profiles. We report such a diagnostic dilemma we encountered in a middle aged female patient with multiple vertebral hemangiomas and compression fracture in D10 vertebra.

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Solitary Myeloma of the Spine

Cited by 36 publications

References 2 publications

Solitary plasmacytoma of the spine. Long-term clinical course

Solitary plasmacytoma of the spine. Long-term clinical course

Multiple Myeloma Presenting with Spinal Cord Compression

Solitary vertebral plasmacytoma causing compression fracture in a patient with multiple vertebral hemangiomas: a diagnosis easily missed!

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