Solitary metastasis of urothelial carcinoma of the urinary bladder to the heart: An unusual clinical manifestation

Spiliotopoulos, Konstantinos; Argiriou, Mihalis; Argyrakos, Theodoros; Haritopoulos, Konstantinos N.; Kanakakis, Konstantinos; Sakellaridis, Timotheos; Charitos, Christos; Bellenis, Ion

doi:10.1016/j.jtcvs.2007.11.046

Cited by 15 publications

(24 citation statements)

References 5 publications

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“…In the other case, the cytodiagnosis suggested malignancy. 4,5,7 In our case, symptoms were similar to previously reported cases. Plain chest radiography showed a "water bottle" heart, and echocardiography was useful to evaluate pericardial effusion.…”

Section: Discussionsupporting

confidence: 90%

“…Including the present case, 14 cases of symptomatic cardiac metastases from UC have been reported so far: 7 bladder cancers and 7 renal pelvic cancers. [4][5][6][7][8][9][10][11][12][13][14][15][16] (Table-1). There have been 3 reported cases of cardiac tamponade from urothelial carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…There have been 3 reported cases of cardiac tamponade from urothelial carcinoma. 4,5,7 In all the cases, symptoms included dyspnea, fatigue, orthopnea and chest pain. Plain chest radiography revealed an enlarged cardiac silhouette or "water bottle" heart.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic urothelial carcinoma to pericardia manifested by dyspnea from cardiac tamponade during systemic chemotherapy: case report and literature review

Hattori

Miyajima

Maeda

et al. 2012

CUAJ

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A 53-year-old man presented for further evaluation due to microscopic hematuria and left lumbar pain. Computed tomography revealed a large tumour in the left renal pelvis with multiple metastases. Despite effective systemic chemotherapy, he developed dyspnea, and was diagnosed with cardiac tamponade. Pericardial involvement in an advanced malignancy is common, but symptomatic cardiac metastasis from urothelial carcinoma is rare. Of the reports of symptomatic cardiac metastasis from urothelial carcinoma, only 3 cases presented as cardiac tamponade. We report here a rare case of cardiac tamponade caused by a renal pelvic carcinoma with positive cytodiagnosis of pericardial effusion. We also summarize and discuss the symptoms, treatment, and prognosis of the pathological condition, and present a brief review of previously published reports.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Metastatic urothelial carcinoma to pericardia manifested by dyspnea from cardiac tamponade during systemic chemotherapy: case report and literature review

Hattori

Miyajima

Maeda

et al. 2012

CUAJ

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“…Cardiac metastases are much less common, with the first case reported in 1967 [7]. At the time of this publication we are aware of only three other reported instances of isolated cardiac metastasis from urothelial cell carcinoma [1-3]. …”

Section: Discussionmentioning

confidence: 99%

“…A review of current literature yields only three other instances of this unusual metastatic pattern [1-3]. We present a 57-year-old male with plasmacytoid urothelial carcinoma (PUC) of the bladder and isolated metastasis to the heart.…”

Section: Introductionmentioning

confidence: 99%

Isolated cardiac metastasis from plasmacytoid urothelial carcinoma of the bladder

et al. 2012

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A 57-year-old male with a history of hypertension presented with shortness of breath, intermittent substernal chest pain, subjective fevers, and a 30-pound weight loss. He was found to have a bladder mass four months prior to presentation, for which he underwent cystoscopy and surgical removal. Pathology demonstrated high-grade superficial plasmacytoid urothelial carcinoma extending into the submucosa but not the muscularis propria. Given the superficial nature of his bladder cancer, a cystectomy was deferred. He was subsequently lost to follow-up care. On arrival, physical exam was notable for tachycardia, tachypnea, and distant heart sounds. An ECG showed an incomplete right bundle branch block and sinus tachycardia. Computed tomography pulmonary angiography revealed a three-cm pericardial effusion. Transthoracic echocardiography confirmed this finding and revealed a mass in the right ventricle (RV) extending into the outflow tract and infiltrating the free wall. The RV was dilated with an estimated RV systolic pressure of 37 mmHg. Pericardiocentesis yielded nearly one liter of serosanguinous fluid with non-diagnostic cytology. Partial median sternotomy with biopsy showed pathologic findings consistent with metastatic urothelial carcinoma, plasmacytoid variant. A PET scan showed increased uptake exclusively in the heart. The oncology team discussed options with the patient including chemotherapy and palliative care. The patient decided to withhold further therapy and went home with hospice care. He died two months later.DiscussionBladder cancer is the fourth most common cancer in men in the United States. Most patients (69%) with metastatic bladder cancer have multiple organs involved; conversely, our patient had a PET scan indicating his disease was localized to the heart. Plasmacytoid urothelial carcinoma is a rare subtype of bladder cancer, and is estimated to make up less than three percent of all invasive bladder carcinomas. At the time of this publication we are aware of only three other reported instances of isolated cardiac metastasis with urothelial bladder origin; none of which were the plasmacytoid variant.ConclusionThis case highlights a previously unreported presentation of plasmacytoid urothelial carcinoma. Clinicians must remember that even superficial cancers can have significant metastatic potential.

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Interventricular Septal Cardiac Metastasis from Transitional Cell Carcinoma of Bladder: a Case Report with Review of Literature

Periasamy,

Chandran,

Goyal

et al. 2023

SN Compr. Clin. Med.

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Solitary metastasis of urothelial carcinoma of the urinary bladder to the heart: An unusual clinical manifestation

Cited by 15 publications

References 5 publications

Metastatic urothelial carcinoma to pericardia manifested by dyspnea from cardiac tamponade during systemic chemotherapy: case report and literature review

Metastatic urothelial carcinoma to pericardia manifested by dyspnea from cardiac tamponade during systemic chemotherapy: case report and literature review

Isolated cardiac metastasis from plasmacytoid urothelial carcinoma of the bladder

Interventricular Septal Cardiac Metastasis from Transitional Cell Carcinoma of Bladder: a Case Report with Review of Literature

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