Solitary intraventricular Hodgkin lymphoma post-transplant lymphoproliferative disease (HL-PTLD): Case report

Azriel, Amit; Towner, James; Gaillard, Frank; Box, Georgia; Rogers, TeWhiti; Morokoff, Andrew

doi:10.1016/j.jocn.2019.08.053

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…Between 1980 and 1999, only eight cases of intracranial involvement in HL were reported [ 12 13 14 15 16 17 18 19 ]. From 2000 to the time of our current case, 39 additional cases have surfaced [ 9 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 ]. The increasing number of case reports underscores the importance of focusing on IC-HL.…”

Section: Discussionmentioning

confidence: 99%

“…We carefully cross-referenced each case report and attempted to make sure that no cases were missed. Through this process, we gathered all the published literature on IC-HL from 1980 to 2023 and summarized it in Table 1 [ 9 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 ]. Based on this table, we aim to highlight some differences between DLBCL and IC-HL.…”

Section: Discussionmentioning

confidence: 99%

“…Of these, our case specifically focuses on HL. To gain deeper insight into these cases, we conducted a detailed literature review spanning from 1980 to 2023, focusing on intracranial HL (IC-HL) cases [ 9 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 ]. Through our literature review and understanding of our case, our goal is to emphasize the key differences between DLBCL and HL.…”

Section: Introductionmentioning

confidence: 99%

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Intracranial Involvement of Systemic Hodgkin Lymphoma: A Case Report and Literature Review

Lee,

Ahn,

Cha

et al. 2024

Brain Tumor Res Treat

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A 27-year-old male patient, previously diagnosed with Hodgkin lymphoma (HL), presented with gait disturbance. Brain MRI showed a 4.5 cm mass lesion in the right occipital lobe, suggesting either intracranial involvement of HL or a potential meningioma. Despite high-dose methotrexate and steroid treatment, the patient’s symptoms persisted, and imaging showed an enlarging mass, leading to surgical intervention. Histopathological examination confirmed central nervous system (CNS) involvement of HL. Postoperatively, the patient underwent whole-brain radiotherapy and demonstrated marked clinical improvement. Our literature review from 1980 to 2023 identified only 46 cases of intracranial HL (IC-HL), underscoring its rarity. Lymphomas represent 2.2% of brain tumors, with 90%–95% being diffuse large B-cell lymphoma (DLBCL). In contrast, the incidence of CNS-HL patients is a mere 0.02%. Notably, IC-HL and intracranial DLBCL have differences in their typical locations and treatment strategies. Unlike DLBCL, which predominantly appears in the supratentorial region (87%), IC-HL is found there in 61.5% of cases. Additionally, 33.3% of IC-HL cases occur in the cerebellum, with 43.5% associated with posterior circulation regions. Furthermore, while biopsy followed by chemotherapy induction is a common strategy for DLBCL, 81.8% of IC-HL cases underwent surgical resection, and only 18.1% had a biopsy alone. The distinct characteristics of IC-HL tumors, including their larger size, attachment to the dura, and fibrotic nature with clear boundaries, might account for the preference for surgical intervention. The unique features of IC-HL compared to DLBCL highlight the need for distinct considerations in diagnosis and management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intracranial Involvement of Systemic Hodgkin Lymphoma: A Case Report and Literature Review

Lee,

Ahn,

Cha

et al. 2024

Brain Tumor Res Treat

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“…Among the other reported cases in the literature diagnosed as isolated cHL in the CNS (summarized in Suppl. Table 1), one patient had an underlying autoimmune hyperthyroidism (Graves' disease) treated with radioactive iodine [17], and another patient had been treated with immunosuppressive drugs after a renal transplant [32], while the past medical history was unremarkable in all other reported cases.…”

Section: Review Of the Literaturementioning

confidence: 99%

Intracerebral manifestation of iatrogenic, immunodeficiency-associated polymorphic B-LPD with morphology mimicking Hodgkin lymphoma: a case report and literature review

2022

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Iatrogenic immunodeficiency-associated lymphoproliferative disorders (IA-LPD) may arise in patients treated with immunosuppressive drugs for autoimmune disease or other conditions. Polymorphic EBV-positive B-lymphoproliferations often have features mimicking Hodgkin lymphoma and typically a self-limited, indolent course. We present an unusual case with isolated, intracerebral manifestation of polymorphic B-LPD with features of classic Hodgkin-lymphoma in an immunosuppressed patient treated with methotrexate and infliximab, including clinical-radiological features and a detailed description of morphological findings, together with a literature review on reported cases of primary CNS manifestation of cHL and IA-LPD with Hodgkin-like morphology. The patient achieved complete remission following neurosurgery with gross total tumor resection and drug withdrawal without any additional treatment. Post-operative staging revealed no evidence for focal relapse or systemic disease during the 18 months follow-up period. Among the previously reported 24 cases of primary, isolated Hodgkin lymphoma in the central nervous system, three similar cases of iatrogenic, IA-LPDs were identified and are discussed here. Polymorphic B-LPD are destructive lesions with a range of morphologic features and disease manifestations. It is clinically important to recognize the spectrum of proliferations with features of classic Hodgkin lymphoma in immunodeficiency, iatrogenic settings, because they are likely to impact the choice of treatment strategies.

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Ciclosporin/mycophenolate-mofetil/prednisolone

2019

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Solitary intraventricular Hodgkin lymphoma post-transplant lymphoproliferative disease (HL-PTLD): Case report

Cited by 5 publications

References 20 publications

Intracranial Involvement of Systemic Hodgkin Lymphoma: A Case Report and Literature Review

Intracranial Involvement of Systemic Hodgkin Lymphoma: A Case Report and Literature Review

Intracerebral manifestation of iatrogenic, immunodeficiency-associated polymorphic B-LPD with morphology mimicking Hodgkin lymphoma: a case report and literature review

Ciclosporin/mycophenolate-mofetil/prednisolone

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