Solitary intraosseous neurofibroma: Report of a unique case

Abstract

Neural tumors located centrally in jaw bones are relatively rare compared with soft tissue neurofibromas. Less than 50 cases have been reported in the literature with a predilection for mandible. This article aims to elucidate a unique case of intraosseous neurofibroma of mandible in a 62-year-old edentulous female patient associated with facial asymmetry due to the swelling extending from the right body of mandible to left body of mandible. The uniqueness of this case is related to the age and extensiveness of this lesion. A review of clinical, radiographic, histological, and immunohistochemical features, and the surgical management pertaining to this case are discussed along with a review of the literature.

Mandibular Neurofibroma: Case Report of a Rare Tumor

“…2 Another 62-year-old edentulous female patient presented with facial asymmetry. 1 In our case the patient had intermittent facial pain with lip and chin paresthesia due to involvement of the inferior alveolar nerve.…”

“…Surgical removal is the treatment of choice for solitary NF. 1 Radical surgery consisting of hemimandibulectomy or en bloc resection of the mandible is often used as a treatment for intraosseous NF. 4 Ueda et al .…”

“…Neurofibromas (NFs) of the mandible are rare, around 50 cases have been reported in the literature. 1 World Health Organization defines NF as a benign tumor of the peripheral nerve sheath phenotype with mixed cellular components, including schwann cells, perineural hybrid cells and intraneural fibroblasts. 2 NFs can occur as a single or multiple lesions associated with neurofibromatosis type 1, which is a systemic condition caused by a germline mutation in the NF1 gene, a tumor suppressor gene located at 17q11.2.…”

A Rare Incidence of Metachronous Neurovascular Lesions in a Child

“…The gross appearance of the tumor is not encapsulated and has a softer consistency. A scrupulous histopathological analysis shows numerous spindle cells with elongated or oval nuclei in a myxoid matrix [ 3 ]. The treatment of intraosseous neurofibroma is radical surgery which includes hemimandibulectomy or enbloc resection of the mandible [ 4 ].…”

The Solitary Variant of Mandibular Intraosseous Neurofibroma: Report of a Rare Entity

“…Very few cases of solitary NF of the oral cavity have been reported in the literature [ 2 ]. WHO defines “neurofibroma as a benign tumor of the peripheral nerve sheath phenotype with mixed cellular components which includes Schwann cells, perineural hybrid cells, and intraneural fibroblasts” [ 3 ]. Only 6% of NFs occur in the oral cavity [ 4 ].…”