Solitary Intracranial Rosai-Dorfman Disease: Case Report and Literature Review

Cao, Xuanye; Luan, SH; Bao, WM; Shen, Chao; Yang, Beomjoo

doi:10.1177/147323001103900553

Cited by 8 publications

(13 citation statements)

References 33 publications

(10 reference statements)

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“…The characteristic histopathologic feature is emperipolesis Figure 1, in which histiocytes, phagocyte, lymphocytes, plasma cells, erythrocytes, or polymorphonuclear leukocytes are intact, this is more appropriate [2–6]. Immunohistochemical analysis consistently shows S-100 protein positivity, particularly with the monoclonal antibody and immunoreactivity against α -1-antichymotrypsin, CD68, EMA, and MAC387 antibodies [2–7]. The characteristic immunohistochemistry features are positive S-100 protein, Ki67 5%, CD79 α , and LCA with negative CD1 α , CK, EMA and GFAP shows in Table 1.…”

Section: Discussionmentioning

confidence: 99%

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Intracranial Rosai-Dorfman Disease

Kumar

Peng

Chen

2014

Case Reports in Radiology

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Rosai-Dorfman disease (RDD) is a rare, benign pseudolymphomatous condition, predominantly involving lymph nodes. Rosai-Dorfman disease (RDD) (sinus histiocytes with massive lymphadenopathy) rarely affects the intracranial region without involvement of other sites. It is a rare and idiopathic histoproliferation disorder characterized by painless lymphadenopathy. We report a case of 43-year-old male who presented with unconsciousness; MRI was done and right temporofrontal mass was found. Excision was done, and on histopathology it confirmed RDD.

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Section: Discussionmentioning

confidence: 99%

“…Prognosis of the disease is good. The most effective therapeutic regimen would be a combination of corticosteroid (prednisolone) and vinca alkaloids (vincristine and vinblastine) with an alkylating agent (cyclophosphamide) [7]. …”

Section: Discussionmentioning

confidence: 99%

Intracranial Rosai-Dorfman Disease

Kumar

Peng

Chen

2014

Case Reports in Radiology

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“…Diseases causing these scenarios can be inflammatory (such as sarcoidosis), infectious (such as tuberculosis), infiltrative (as in malignancies, lymphomas, meningeal carcinomatosis) or compressive secondary to meningeal hypertrophy (as in Rosai–Dorfman disease2 or extramedullary haemopoiesis due to thalassaemia) 24 25…”

Section: Aetiologiesmentioning

confidence: 99%

“…This is suspected from a positive family history of loss of vision in the young and diagnosed by genetic testing, since the majority of such patients have one of three mitochondrial DNA point mutations (11 778, 14 484 and 3460) 39. Rosai–Dorfman disease is an infiltrative disease of histiocytes and lymphocytes that causes progressive loss of vision by impingement of hypertrophic dura on the optic nerve 2. There are cryptogenic causes of loss of vision in the young adult where the presenting symptom is visual loss with no defined aetiology.…”

Section: Aetiologiesmentioning

confidence: 99%

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Acute neurological visual loss in young adults: causes, diagnosis and management

Ayoubi

Hamam²

2015

Postgraduate Medical Journal

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Visual loss in the young adult can be caused by demyelinating diseases, inflammatory and autoimmune processes, infections, ischaemic events, and compressive lesions of the optic nerve. Diagnosis of the aetiologies of visual loss is reached by combining data from radiological studies, electrophysiological tests, and blood and cerebrospinal fluid analysis. Treatment is primarily aimed at decreasing the insult on the optic nerve and eventually controlling the primary disorder. The literature discusses separately the different aetiologies of visual loss. We present a review of the clinical characteristics of visual loss in the young adult, the different diagnostic measures, and the latest therapeutic strategies. The aim of this work is to summarise this entity in a practical way to guide clinicians in the diagnosis and management of this disorder.

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Rosai-Dorfman Disease of the Central Nervous System

et al. 2014

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Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy (SHML), is an uncommon benign idiopathic lymphoproliferative disorder. The histologic hallmark of RDD is the finding of emperipolesis displayed by lesional histiocytes. While RDD most commonly affects lymph nodes, extranodal involvement of multiple organs has been reported, including the central nervous system (CNS). However, CNS involvement in RDD is rare and is not well characterized. As a result, therapeutic approaches to CNS involvement in RDD are not well established. Herein we report 6 cases of RDD with isolated CNS involvement and review the literature on RDD with CNS involvement. One of the presented cases exhibited intramedullary involvement of the spinal cord—a very rare form of RDD with CNS involvement.

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Solitary Intracranial Rosai-Dorfman Disease: Case Report and Literature Review

Cited by 8 publications

References 33 publications

Intracranial Rosai-Dorfman Disease

Intracranial Rosai-Dorfman Disease

Acute neurological visual loss in young adults: causes, diagnosis and management

Rosai-Dorfman Disease of the Central Nervous System

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