Solitary infantile myofibromatosis involving the clavicle

Imaizumi, Satoshi; Ogose, Akira; Hotta, Tomomitsu; Takahashi, Hideaki; Emura, Iwao

doi:10.1007/s002560050550

Cited by 10 publications

(6 citation statements)

References 6 publications

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“…Furthermore most of the previously described cases with a solitary lesion affecting bone involved the craniofacial bones [2] , [3] , [4] , [5] , [6] , [7] , and only a few cases affected the appendicular skeleton. Several affected extra-craniofacial sites have been sporadically reported, for example: femur [8] , tibia [9] , [10] , [11] , humerus [1] , ulna [12] , [1] , and clavicle [13] . The age of the patients was usually less than 2 years [3] , and no adult case has been reported, to our knowledge.…”

Section: Discussionmentioning

confidence: 99%

“…There are a few reports of myofibromas in adults [2] , [3] , [7] , [9] , [11] , [12] , [13] , [14] , [15] . Daimaru et al reported five cases of myofibromas in adult patients [13] . The tumors clinically presented as superficial, painless, and slowly enlarging nodules, usually of more than 10 years׳ duration, that occurred in the upper (two cases) and lower (two cases) extremities or the buccal mucosa (one case).…”

Section: Introductionmentioning

confidence: 99%

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Solitary intraosseous myofibroma of the tibia in an adult patient: A case report

Shemesh

Kosashvili

Sidon

et al. 2014

Journal of Bone Oncology

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Myofibromas are mesenchymal tumors showing myofibroblastic differentiation and found most frequently in the head and neck region. While several cases of myofibromas have been reported in adults, they have not been described in long bones of the appendicular skeleton. We describe an otherwise healthy young woman who presented with a progressive incapacitating pain in her right shin. Imaging studies revealed a well-circumscribed osteolytic lesion with slight marginal sclerosis confined to the proximal tibia metaphysis, without a soft tissue component. Surgical intervention was performed and histological examination identified a myofibroma.This case represents an extremely rare occurrence of an intraosseous myofibroma involving a long bone in an adult patient. Although solitary myofibroma is a rare lesion in the skeletal bones of adults we believe it should be included in the differential diagnosis of a solitary lytic mass in bone, especially if it is associated with pain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solitary intraosseous myofibroma of the tibia in an adult patient: A case report

Shemesh

Kosashvili

Sidon

et al. 2014

Journal of Bone Oncology

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“…[ 10 , 15 , 22 ] Expansile mass may also be accompanied by pathological fracture. [ 10 , 14 , 15 , 18 , 19 ] MRI usually shows a hypo- to isointense signal with adjacent muscle on T1-weighted images and a homogeneous or inhomogeneous hyperintense signal on T2-weighted images with marked enhancement on postcontrast T1-weighted images. [ 10 , 22 , 23 ] Sometimes, the mass has nonenhanced central portion, called a “target sign”, which corresponds to the presence of central necrosis on pathological examination.…”

Section: Discussionmentioning

confidence: 99%

Solitary myofibroma of the lumbar vertebra in young adult

Lee

Ha²,

Kang³

et al. 2017

Medicine

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Background:Solitary myofibroma of the spine is extremely rare, particularly among adults. To the best of our knowledge, only 3 cases affecting lumbar vertebrae have been reported in the English language literature. Of them, only 1 case was an adult case of solitary myofibroma affecting the L1 vertebra.Methods:We report a case of solitary myofibroma affecting the L5 vertebra in an 18-year-old man and the postoperative imaging of solitary myofibroma for the first time. Conventional radiographs demonstrated an expansile osteolytic lesion with thinned cortex and marginal sclerosis. Computed tomography (CT) showed a purely osteolytic expansile lesion with partial disappearance of thinned cortex. MRI of the lesion revealed an isointense signal on T1-weighted images, an inhomogeneous slightly hyperintense signal on T2-weighed images, and homogeneous avid enhancement with gadolinium.Results:Surgical excision was performed and the lesion was diagnosed as solitary myofibroma on pathological examination. One-year follow-up postoperative CT demonstrated decreased size of the osteolytic lesion with sclerotic change. Four-year follow-up postoperative MRI revealed complete resolution of the lesion replaced by normal fatty marrow.Conclusion:If a benign-looking expansile osteolytic lesion reveals a homogeneously isointense signal on T1-weighted image, inhomogeneous slightly hyperintense signal on T2-weighted image, and homogeneous avid enhancement with gadolinium, solitary myofibroma should be considered in the differential diagnosis of spine bone tumors. It can be resolved completely.

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“…Our results differ from the typical MRI appearance of myofibromatosis. Most commonly, a low to moderately low intensity signal on T1, high intensity signal on T2 13,26,27 and marked enhancement post contrast are encountered 26,27 .…”

Section: Discussionmentioning

confidence: 99%