Solitary infantile choriocarcinoma of the liver: MRI findings

Hoef, M. van der; Niggli, Felix; Willi, Ulrich; Huisman, Thierry A.G.M.

doi:10.1007/s00247-004-1212-x

Cited by 22 publications

(17 citation statements)

References 10 publications

(26 reference statements)

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“…In spite of these strict criteria, there are indeed still some extragonadal (other than uterine, testes, and ovary) choriocarcinomas . Most reported primary extragonadal choriocarcinomas were in the mediastinum [1,7,8,14,16,20,21] and stomach [13], and only very rarely such choriocarcinomas occur in liver [3][4][5]24]. Most reported primary hepatic choriocarcinomas were of infantile type (their origin was still controversial, and they may represent metastasis from occult placental choriocarcinoma) [5,24], and there were only two welldocumented cases in adults [3,4].…”

Section: Introductionmentioning

confidence: 98%

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Shi

Cao²,

Wei

et al. 2009

Virchows Arch

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Primary choriocarcinomas of the liver are rare. Previous reported cases were mostly in infants with only rare adult cases. Here, we presented five adult cases. The patients were all males, with an average age of 41.6 years (from 36 to 48 years). Clinical presentations included right upper abdominal pain or abdominal distension. All patients presented with a large hepatic mass on ultrasonography that measured 11 cm on average in the greatest diameter. Elevated serum human chorionic gonadotropin (HCG) levels were noted in all cases. At presentation, the tumor was confined to the liver in two patients and therefore surgically resected. The other three patients presented with extrahepatic metastases on imaging study and therefore only received chemotherapy. All five patients died from the tumor within 2 to 8 months. Autopsy was performed for all five cases. The autopsy confirmed that the choriocarcinoma was confined to the liver in two surgically resected cases. The other three patients had metastatic choriocarcinoma in the lung (two patients), peritoneum (one patient), adrenal glands (one patient), and brain (one patient). None of the patients had any evidence of a testicular tumor or scar after examination of the entirely submitted testes. No tumor was observed in central nervous system, mediastinum, or other organs other than described above. Grossly, the primary tumors were large, soft, hemorrhagic, and with foci of necrosis. Histologically, the tumors were composed of mononucleated trophoblastic cells with round nuclei, clear cytoplasm, and prominent nucleoli admixed with large, multinucleated syncytiotrophoblastic cells. Immunohistochemically, tumor cells were strongly positive for keratin, HCG, and focally positive for human placental lactogen. Ki-67 proliferation index was high (mean 75%) in the mononucleated trophoblastic cells. Our series is the largest one to document primary hepatic choriocarcinoma in adults. Although these tumors are rare, they behave in a very aggressive fashion.

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Section: Introductionmentioning

confidence: 98%

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Shi

Cao²,

Wei

et al. 2009

Virchows Arch

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“…It is a very rare tumor and only 32 cases have been described in the literature. Newborn infants tend to present clinically with a characteristic picture of anemia, hepatomegaly, hemorrhagic liver tumors, and precocious puberty Followed by rapid progression to death and maternal choriocarcinoma [12]. In 1968, Witzleben et al described a constellation of clinical and laboratory findings that were seen in cases of "infantile choriocarcinoma syndrome": presentation at 5 weeks to 7 months of age, anemia and/or pallor, and hepatomegaly.…”

Section: Discussionmentioning

confidence: 99%

“…The primary lesion or the metastatic lesions may show large vascular channels on CT as well as sonography with color and duplex Doppler [15]. The MR imaging appearance varies due to the presence or absence of hemorrhage as well as central necrosis with peripheral enhancement pattern with or without filling of the lesion on delayed images [12]. The periphery of the mass may show high signal intensity on T1-weighted images (T1WI) and T2-weighted images (T2WI) suggesting hemorrhagic components.…”

Section: Discussionmentioning

confidence: 99%

“…Choriocarcinoma usually has heterogeneous T1 and T2 signal intensity with large areas of central necrosis. T1 hyper-intense hemorrhagic areas are frequently encountered in addition to fluid filled cysts with high protein content that are T1 and T2 hyper-intense and these features are like ovarian choriocarcinoma [12,16]. When compared to uterine choriocarcinoma, the imaging features are similar except that uterine choriocarcinoma tend to be infiltrative rather than presenting with masses.…”

Section: Discussionmentioning

confidence: 99%

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Infantile Choriocarcinoma of the Liver: Case Report and Review of the Literature

AlSharif¹,

Karsou²

2017

Oncology and cancer case reports

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“…β-Human chorionic gonadotropin (β-HCG) levels in serum and urine characteristically elevated because the tumor arises from trophoblastic cells. In the absence of a known maternal choriocarcinoma, the diagnosis is frequently incorrect because of the rarity of the lesion and the non-specific MRI findings [3]. Choriocarcinoma in children only reported in 30 cases [1].…”

Section: Discussionmentioning

confidence: 99%

Choriocarcionoma in an Infantile Patient

Pradjatmo¹

2015

Gen Med (Los Angel)

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Clinical diagnosis of choriocarcinoma may be difficult in post-menopause or children and ectopic origin. According to its histologic origin, it is classified as gestational or nongestational choriocarcinoma. Gestational choriocarcinoma its origin derived from placental trophoblast and nongestational choriocarcinoma-derived from a germ cell. However, DNA and genetic analysis can be used to define the origin of choriocarcinoma. Usually, the DNA examination and genetic analysis have not been used widely in clinical services. In this case the diagnosis to considered as a primary nongestational choriocarcinoma just based on clinical and laboratory finding. This article is aimed to remind the doctors who treat cases choriocarcinoma and is no doubt in deciding whether the origin of the disease from gestational or nongestational should carry out an investigation DNA and genetic analysis.

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Solitary infantile choriocarcinoma of the liver: MRI findings

Cited by 22 publications

References 10 publications

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Infantile Choriocarcinoma of the Liver: Case Report and Review of the Literature

Choriocarcionoma in an Infantile Patient

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