Solitary fibrous tumour of the mouth: report of two cases involving the tongue and cheek

Abstract

We describe two additional cases of solitary fibrous tumour (SFT) affecting the mouth. SFT is very uncommon in the oral cavity and we found only 14 cases reported in the literature. Our two cases were well circumscribed, slow growing tumours that, after surgical removal, did not recur. Case 1 was a 3 cm nodule on the right cheek. Hypo and hypercellular adjacent areas were mainly patternless, and the stroma was formed by thin collagen fibrils. Case 2 was a 4.8 cm mass in the anterior portion of the tongue. Microscopically it was formed by spindle cells embedded in a vascularized sclerotic collagen matrix. Some areas were hypercellular with scarce collagen fibrils. The immunohistochemical findings were similar in both cases, with strong immunoreactivity for vimentin, CD34, bcl-2, focal positivity for Ki-67 and negativity for other immunomarkers. Based on these clinical, microscopical and immunohistochemical features the final diagnosis of these two cases was SFT. Diagnosis of SFT is difficult and, although uncommon, it should be considered in the differential diagnosis of oral soft tissue tumours.

An Aggressive Solitary Fibrous Tumor with Evidence of Malignancy: A Rare Case Report

“…They are usually slow growing, asymptomatic and largest size reported in literature is around 4.8 cm in the oral cavity [9,14] while sizes of up to 26 cm have been reported in other sites [15]. The present case was similar in age and sex predilection to that of a classical SFT but exhibited aggressive clinical behavior attaining a huge size and causing considerable debilitation to the patient.…”

“…Since then, there has been considerable debate regarding its origin with various hypothesis of it arising from mesothelium, fibroblast, primitive cells, pluripotential mesenchymal cells, etc. Recently due to various reports of its ubiquitous occurrence in almost every site of the body, it is now believed to arise from dendritic mesenchymal cells [2,9]. Over the years, it has been referred to by various names like benign mesothelioma, solitary fibrous mesothelioma, myofibroblastoma, etc.…”

“…Over the years, it has been referred to by various names like benign mesothelioma, solitary fibrous mesothelioma, myofibroblastoma, etc. [9] reflecting the controversies regarding its histogenesis [8,10].…”

Crotamine Pharmacology Revisited: Novel Insights Based on the Inhibition of KV Channels

“…Therefore, crotamine putative functional dyad (Arg31-Trp32) was determined by superimposition for best fit with well described functional dyads of several sea anemone and scorpion toxins acting on voltage-gated potassium channel. Secondary structure, ␣-helix (Vargas et al, 2002), ␤-sheet (yellow), loops (Shon et al, 1998), and SS-bonds (green). A, crotamine dipole and presumed functional dyads (Tyr1-Lys2 and Arg31-Trp32); dipole momentum is depicted in purple.…”

“…PDB models:1Z99, crotamine from C. durissus terrificus (left); 1FD3, human ␤-defensin (center); 1WQK, APETx-1 from the sea anemone Anthopleura elegantissima (right). Secondary structure, ␣-helix (Vargas et al, 2002), ␤-sheet (yellow), loops (Shon et al, 1998), and SS-bonds (green). properties of crotamine.…”