Solitary fibrous tumour of the female genital tract: a clinicopathological analysis of 25 cases

Yang, Eric J.; Howitt, Brooke E.; Fletcher, Christopher D.�M.; Nucci, Marisa R.

doi:10.1111/his.13430

Cited by 60 publications

(87 citation statements)

References 57 publications

(106 reference statements)

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“…SFTs usually show strong positivity with CD34, bcl‐2 and CD99, while they are negative for SMA, desmin and inhibin. The thecomas and fibromas show positivity with inhibin, while fibroids show uptake of desmin and SMA . The typical immunohistochemistry findings of the positivity with bcl‐2 and CD‐34 in the background of spindle‐shaped cells helped confirm the diagnosis of SFT in the present patient.…”

Section: Discussionsupporting

confidence: 71%

“…They are extremely rare in the female reproductive system and have a predilection for the vulva, vagina and cervix . To date, only one case of benign SFT of the ovary has been reported, but the patient was of the postmenopausal age group . To the best of our knowledge, this is the first case report of a benign SFT arising from the ovary in a patient in the reproductive age group.…”

Section: Discussionmentioning

confidence: 79%

“…Ovarian SFTs are often confused with fibroids and ovarian sex cord stromal tumors like granulosa cell tumors, Sertoli‐Leydig cell tumors, thecoma, fibroma, gynandroblastoma etc . The SFTs do not show an increase in serum CA‐125, alpha‐fetoprotein, beta‐human chorionic gonadotropin or inhibin levels, which can help in differentiating them from solid ovarian tumors and sex cord stromal tumors.…”

Section: Discussionmentioning

confidence: 99%

“…There are no specific imaging features suggestive of SFT. On ultrasound, they usually have a solid appearance with occasional cystic changes and may be differentiated from fibroids due to the lack of whorls . On CT scan, they appear as well‐circumscribed, solid cystic masses that may show hypodense areas due to necrosis or cystic degeneration.…”

Section: Discussionmentioning

confidence: 99%

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Solitary fibrous tumor of the ovary

Meena

Jindal

Duggal

et al. 2018

J of Obstet and Gynaecol

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Solitary fibrous tumor of the ovary

Meena

Jindal

Duggal

et al. 2018

J of Obstet and Gynaecol

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“…Occasional fibromas are quite vascular, which prompts brief mention of the potential differential diagnosis with solitary fibrous tumor, rare examples of which have been primary in the ovary. 20 The classic features of solitary fibrous tumor, particularly dilated, branching, so-called staghorn-like blood vessels, should bring that neoplasm to mind and prompt staining for STAT6, which should be discriminatory in most cases although it should be noted that in the study just cited, 5% of tumors in the fibroma-thecoma category (evaluated for comparison) showed some weak focal staining for STAT6.…”

Section: Fibroma Including Cellular Fibromamentioning

confidence: 97%

Ovarian Sex Cord–Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD

Young

2018

Archives of Pathology &Amp; Laboratory Medicine

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Context.— This year being the 60th anniversary of the publication of the excellent book Endocrine Pathology of the Ovary by John McLean Morris, MD, and Robert E. Scully, MD, the writer reflects on that work and in particular the remarkable contributions of its second author to our knowledge in this area. Objective.— To review ovarian sex cord–stromal tumors. Data Sources.— Literature and personal experience. Conclusions.— The essay begins with remarks on the oftentimes straightforward stromal tumors of the ovary because the commonest of them, the fibroma, dominates from the viewpoint of case numbers. Then, the sclerosing stromal tumor and the peculiar so-called luteinized thecomas of the type associated with sclerosing peritonitis are discussed in greater detail and their wide spectrum is illustrated. Brief mention is made of 2 rare neoplasms: the ovarian myxoma and signet-ring stromal tumor. Discussion then turns to the more recently recognized intriguing tumor tentatively designated microcystic stromal tumor and the commonest malignant tumor in this entire family, the so-called adult granulosa cell tumor, which despite its name may occasionally be seen in young individuals. The second variant of granulosa cell tumor—that which usually, but not always, occurs in the young—the so-called juvenile granulosa cell tumor, is then discussed. In the section of Sertoli-Leydig cell tumors, particular attention is focused on unusual tumors with heterologous elements and the remarkable so-called retiform tumors, which have a predilection for the young, often have distinctive gross features, and exhibit slitlike spaces and papillae. The essay concludes with consideration of the sex cord tumor with annular tubules.

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NTRK and other recently described kinase fusion positive uterine sarcomas: A review of a group of rare neoplasms

Croce

Hostein

McCluggage

2020

Genes Chromosomes & Cancer

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The landscape of uterine sarcomas has greatly expanded in recent years to include neoplasms with recurrent gene fusions, such as BCOR and YWHAE translocated high‐grade endometrial stromal sarcomas. Sophisticated molecular techniques have also resulted in the description of “new” entities associated with recurrent kinase fusions involving NTRK and RET as well as COL1A1‐PDGFB rearranged uterine sarcomas. These rare neoplasms will be discussed in this review, highlighting that some of the underlying molecular events are clinically actionable and potentially susceptible to targeted therapy. While relatively few of these neoplasms have been described to date, likely being previously lumped under the spectrum of undifferentiated uterine sarcoma, the number of cases will expand in the future given their recognition and the increasing availability of molecular testing. These neoplasms have overlapping morphology (often with a “fibrosarcoma‐like” appearance) and immunohistochemical features, and are characterized by variable clinical outcomes. Although immunohistochemistry may assist in some cases, a definitive subclassification requires confirmatory molecular studies. As these molecular assays may not be routinely available in most laboratories, referral to reference centers may be needed. In order to assist the pathologist, we suggest a diagnostic algorithm for routine practice when dealing with a malignant or potentially malignant uterine spindle cell neoplasm.

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Solitary fibrous tumour of the female genital tract: a clinicopathological analysis of 25 cases

Abstract: Gynaecological SFT can be diagnosed reliably with careful morphological evaluation and judicious use of immunohistochemical stains, and should be considered in the diagnostic workup of spindle cell tumours of unclear lineage in the female genital tract.

Cited by 60 publications

References 57 publications

Solitary fibrous tumor of the ovary

Solitary fibrous tumor of the ovary

Ovarian Sex Cord–Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD

NTRK and other recently described kinase fusion positive uterine sarcomas: A review of a group of rare neoplasms

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