Solitary fibrous tumour of the oral cavity with histological features of aggressiveness

González-García, Raúl; Usandizaga, J.L. Gil-Díez; Nam, Soon-Yuhl; Campo, Francisco José Rodríguez; Naval-Gías, Luis

doi:10.1016/j.bjoms.2005.09.001

Cited by 15 publications

(20 citation statements)

References 26 publications

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“…Malignant SFT cases account for 10-15% of those reported and when present, these have shown to have recurrent and distant metastases. 7,8 The current case showed no features to suggest a malignant process.…”

Section: Discussionmentioning

confidence: 51%

Solitary fibrous tumour of the cheek: An unusual presentation of a rare soft tissue tumour

Greenall

Jones

et al. 2014

Ultrasound

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This case report discusses the unusual presentation and ultrasound features of a solitary fibrous tumour of the face. Solitary fibrous tumour is an uncommon form of soft tissue tumour which, although seen predominantly within the lung pleura, can occur throughout the body in sites such as the peritoneum, mediastinum and head and neck. Ultrasound is an excellent imaging modality in the assessment of soft tissue masses in the head and neck. The ultrasound features demonstrated by this example of solitary fibrous tumour are reviewed. This report also highlights that ultrasound alone is ultimately limited in reaching a definitive diagnosis. The roles of other investigations such as ultrasoundguided biopsy and cross-sectional imaging are discussed.

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Section: Discussionmentioning

confidence: 51%

Solitary fibrous tumour of the cheek: An unusual presentation of a rare soft tissue tumour

Greenall

Jones

et al. 2014

Ultrasound

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“…The etiopathogenesis of the tumor remains unclear. Two theories have been advocated in the literature to clarify this issue [7]. The first one assumes multidirectional differentiation of fibroblasts and mesenchymal multipotential cells in connective tissue [7].…”

Section: Discussionmentioning

confidence: 99%

“…Convincingly, due to such a location, it was initially stated that this was a benign variant of mesothelioma [2,6]. Subsequent ultrastructural research revised this opinion and revealed that SFT originated from interstitial stem cells localized mainly in the soft tissues of various body sites [2,7]. Despite knowledge of the tumor's origin and reproducible immunohistochemical profile, its biology is still incompletely explained [2,8].…”

Section: Introductionmentioning

confidence: 99%

“…Most cases express benign behavior, although according to the literature, about 5-20% of tumors may present features of aggressiveness along with local recurrences, as well as distant metastases to the liver, lungs, bones, mesentery and the retroperitoneal space [7,9,10]. Recurrences usually present more advanced histology than primary tumors.…”

Section: Introductionmentioning

confidence: 99%

“…Tumors within the thyroid gland, larynx, epiglottis, parapharyngeal space, major salivary glands, nasopharynx, paranasal sinuses, orbit, as well as cerebral meninges, are considerably rare [7]. Most patients with SFT of the oral cavity present with a slow growing, non-tender mass of various dimensions located within the submucosal tissue [1,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Solitary fibrous tumor in the oral cavity: a and diagnostic dilemma

Chomik¹,

Michcik²,

Michajłowski³

et al. 2012

pdia

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A Ad dd dr re es ss s f fo or r c co or rr re es sp po on nd de en nc ce e: : Piotr Chomik DDS, Department of Oral and Maxillofacial Surgery, Medical University of Gdansk, 7 Smoluchowskiego St, Poland, phone Case report A b s t r a c tThe investigators wish to discuss the diagnostic difficulties, histology and immunohistochemical profile of a solitary fibrous tumor (SFT) based on the presented case, as well as previously reported cases within the oral cavity. A young woman was referred to the Department of Maxillofacial Surgery, Medical University of Gdansk, Poland, due to a considerable palpable mass within the hard palate. Pain and discomfort caused by the tumor's location were the main complaints. A clinical examination revealed a tumor of the right hard palate along the alveolar crest, measuring approximately 5 cm × 3 cm. Panoramic X-ray depicted a bone defect of the alveolar crest around tooth 17. Histological and immunohistochemical evaluation of the biopsy specimen and resected tumor established the diagnosis of SFT. This rare spindle cell neoplasm of mesenchymal origin is typical of serosal sites and approximately 80 cases within the head and neck region have been reported so far. The hard palate is one of the least frequent locations. Approximately 5-20% of lesions may present features of aggressiveness. The authors wish to emphasize that the diagnosis of SFT is challenging due to a relatively small number of cases reported in the literature, uncertain etiology of the tumor, as well as clinical and histological similarity to other, more frequently occurring benign neoplasms of mesenchymal origin, i.e. hemangiopericytoma, myofibroblastoma, schwannoma, neurofibroma, leiomyoma, as well as inflammatory disorders, especially nodular fasciitis. Radical excision of the tumor is mandatory for effective treatment due to the possibility of recurrence and malignant transformation after subradical resection.K Ke ey y w wo or rd ds s: : solitary fibrous tumor, oral cavity, hard palate, diagnosis.

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Solitary Fibrous Tumor of the Oral Cavity: Clinicopathologic and Immunohistochemical Study of 21 Cases

O’Regan

Vanguri

Allen

et al. 2009

Head and Neck Pathol

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We describe clinical, morphologic, and immunohistochemical features of 21 cases of solitary fibrous tumor presenting in the oral cavity. There were 9 male and 12 female patients with a median age of 51 years (range 37–83). The most common locations included the buccal mucosa (the most common site), lip, maxillary or mandibular vestibule and tongue. Histopathologic examination showed well-circumscribed tumors with two well-defined patterns: the classic pattern with densely cellular areas alternating with hypocellular areas in a variably collagenous, vascular stroma and a more uniformly sclerotic pattern with only subtle classic areas. The spindle-shaped neoplastic cells consistently showed immunoreactivity for antibodies directed against CD34. Five of nineteen cases (26%) were reactive for CD99 and 19 of 19 for Bcl-2. Follow-up information was available in 17 cases and averaged 54 months, with no evidence of recurrence or metastasis in any of these patients. Awareness that solitary fibrous tumor may present in the oral cavity is important so that confusion with other spindle cell neoplasms can be avoided. We also briefly describe the differential diagnosis and compare this series, the largest single series of intraoral SFT, to cases previously reported in the literature.

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Solitary fibrous tumour of the oral cavity with histological features of aggressiveness

Cited by 15 publications

References 26 publications

Solitary fibrous tumour of the cheek: An unusual presentation of a rare soft tissue tumour

Solitary fibrous tumour of the cheek: An unusual presentation of a rare soft tissue tumour

Solitary fibrous tumor in the oral cavity: a and diagnostic dilemma

Solitary Fibrous Tumor of the Oral Cavity: Clinicopathologic and Immunohistochemical Study of 21 Cases

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