Solitary Fibrous Tumors: A Series of Lesions, Some in Unusual Sites

Khalifa, Mahmoud A.; Montgomery, Elizabeth A.; Azumi, Norio; Gomes, Mario N.; Zeman, Robert K.; Min, Kyung Whan; Lack, Ernest E.

doi:10.1097/00007611-199708000-00005

Cited by 63 publications

(38 citation statements)

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“…Tumors with similar features had been reported in the literature with different names, frequently used interchangeably, such as "benign spindle cell tumor" [7,65], "fibroma" [9], "spindle cell lipoma" [49,58], "solitary fibrous tumor" [12,31], "myofibroblastoma" [68], "myogenic stromal tumor", or "unusual variant of leiomyoma" [16,17]. The unifying morphological criterion of all these lesions is a well-circumscribed proliferation of blandlooking spindly to oval-epithelioid cells, haphazardly arranged or forming short fascicles and/or cellular clusters, and variably admixed with thick or less frequently thin collagen bands.…”

Section: Discussionmentioning

confidence: 88%

“…We consider such tumors as the herald of the postcoming lesions labeled in the literature with different names such as "benign spindle cell tumor" [7,39], "spindle cell lipoma" [36,49,58], fibroma [9], "solitary fibrous tumor" (SFT) [12,31,55], "myofibroblastoma" (MFB) [68], "myogenic stromal tumor" [3,16,17], and "atypical variant of leiomyoma" [16,17]. On the whole, this category of neoplasms has received little attention by clinicians and pathologists so that their distinctive features are not yet well delineated.…”

Section: Introductionmentioning

confidence: 99%

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Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept

Magro

Bisceglia

Michal³

et al. 2002

Virchows Arch

180

165

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We reviewed the clinico-pathological features of a series of 13 cases of benign spindle stromal tumors (BSSTs) of the breast relating to a basic common theme consisting of a well-circumscribed proliferation of vimentin+/CD34+/BCL-2+/CD99+ spindly to oval-epithelioid cells, variably arranged in haphazard to short fascicular growth pattern, with interspersed thick or thin collagen bands. Morphological variations included atypical mono- or multi-nucleated cells in five cases and a mature lipomatous tumor component, varying from focal to prominent, in eight cases. Based on morphological and immunophenotypical features, a distinction was made between two main subtypes of these tumors--fibroblastic and myofibroblastic. The former subtype included two cases respectively represented by a typical solitary fibrous tumor (SFT) and a neoplasm labeled "spindle-cell lipoma (SCL)-like tumor", closely reminiscent of soft tissue SCL. Both tumors had cells with fibroblastic-like appearance, haphazardly arranged and immunoreactive for vimentin, CD34, BCL-2, and CD99. The latter subtype, comprised nine cases exhibiting evidence of myofibroblastic differentiation (desmin and alpha-smooth muscle actin) which were classified as myofibroblastomas (MFBs). The remaining two cases were defined as "mixed BSSTs", having typical features of diverse neoplasms, respectively represented by a case of MFB with focal SFT and pleomorphic/SCL-like areas, and SFT with focal MFB-like component. The common basic morpho-immunophenotypical features, the possibility that both fibroblastic and myofibroblastic tumors may contain an additional mature lipomatous component, and the existence of hybrid stages (mixed BSSTs) strongly support the view that such tumors belong to the same category of lesions. We postulate that the precursor of all these neoplasms is the vimentin+/CD34+ cells of the mammary stroma, the well-known inherent plasticity of which to differentiate toward several mesenchymal lines, provides the explanation for the phenotypic heterogeneity of these neoplasms. Accordingly, the encompassing term "benign spindle stromal tumors of the breast" is advocated for such tumors.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept

Magro

Bisceglia

Michal³

et al. 2002

Virchows Arch

180

165

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“…Concomitant chest wall resection can be necessary if the tumour densely adheres to or invades the chest wall [65]. Inverted tumours [34] that grow inside the lung parenchyma (<3% of cases) may require lobectomy or sleeve lobectomy [37,54,91,92].…”

Section: Surgerymentioning

confidence: 99%

Solitary fibrous tumours of the pleura

Arab

2011

European Journal of Cardio-Thoracic Surgery

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SummarySolitary fibrous tumours of the pleura are rare. They are mesenchymal in origin. Initially, they were described in the pleura, but lately they have been reported in many other sites. Although the majority of these tumours are benign, some of them are malignant. Their unpredictable clinical course is probably related to their histological and morphological characteristics. The benign tumours may remain unproblematic for several years before changing into a malignant form. In order to define more accurately the clinical behaviour, diagnosis, management and outcome of these rare tumours, we reviewed the literature with particular attention to clinical presentation, methods of diagnosis, treatment and outcome. Furthermore, a modified algorithm was proposed for the management of these tumours.

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“…Many mesothelial or submesothelial neoplasms, as well as inflammatory pseudotumours, are now included in the SFT category because they display comparable morphological features and, generally, a similar biological behaviour; probably because of their common origin from the same cell line [3]. SFTs are predominantly intra-thoracic tumours arising from pleura or other mediastinal sites, but extra-thoracic sites have been reported [4,5]. Hepatic localisation is particularly rare: the most recent review, currently in press [6], of 38 worldwide cases of liver SFT since 1959, includes a previous case from our institution [7].…”

Section: Introductionmentioning

confidence: 99%