Solitary Fibrous Tumor of the Infratemporal Fossa

Freiser, Monika E.; Castaño, Johnathan E.; Whittington, Elizabeth; Arnold, David; Sidani, Charif

doi:10.3941/jrcr.v8i12.1742

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…The average time of intrathoracic drain was 3.6 ( 1 – 9 ) days. The average hospital stay was 15 ( 4 – 22 ) days, and no mortality occurred. All patients were discharged from the hospital following an uneventfully recovery.…”

Section: Resultsmentioning

confidence: 98%

“…A solitary fibrous tumour (SFT) is a rare, slow-growing, mesenchymal neoplasm arising from the pleura, which is unrelated to asbestos exposure or cigarette smoking ( 1 ) and was initially described in 1931 ( 2 ). Over the past 80 years, SFTs have been identified in numerous extrapleural locations, including the nasal cavity ( 3 ), breast ( 4 ), stomach ( 5 ), bronchus ( 6 ), head and neck ( 7 ), liver ( 8 ), oesophagus ( 9 ), pelvic ( 10 ), pancreas ( 11 ), prostate ( 12 ), orbit ( 13 ), central nervous system ( 14 ), parotid gland ( 15 ), kidney ( 16 ), lung ( 17 ), sella turcica ( 18 ), heart ( 19 ), conus medullaris ( 20 ), omentum ( 21 ), infratemporal fossa ( 22 ), bladder ( 23 ), soft tissues of the extremities ( 24 ), palatine tonsil ( 25 ), diaphragm ( 26 ), mesentery ( 27 ), lumbar spine ( 28 ), thymus ( 29 ), oral cavity ( 30 ), spermatic cord ( 31 ), thyroid ( 32 ), rectum ( 33 ), salivary glands ( 34 ), retroperitoneum ( 35 ), larynx ( 36 ), trachea ( 37 ), adrenal gland ( 38 ), female genital tract ( 39 ), periosteum of bone ( 40 ), mediastinum ( 41 ) and hypopharynx ( 42 ).…”

Section: Introductionmentioning

confidence: 99%

“…Postoperative haemorrhage occurred in 1 patient and he received surgical intervention for haemostasis. The average hospital stay was 15 ( 4 – 22 ) days, and no mortality occurred. The mean length of the postoperative follow-up was 37.6 ( 1 – 67 ) months.…”

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confidence: 98%

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Primary intrapulmonary solitary fibrous tumours

et al. 2018

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Due to the extreme rarity of primary intrapulmonary solitary fibrous tumours (SFTs), their clinical course, imaging characteristics, diagnosis, treatment and prognosis are poorly understood. The present study therefore assessed the diagnosis and management of primary intrapulmonary SFTs and systematically reviewed previously reported cases in the literature. A total of 5 patients who underwent resection for primary intrapulmonary SFTs were enrolled in the present study and their clinical course, tumour characteristics, management and survival were assessed in this retrospective study. Relevant studies regarding primary intrapulmonary SFTs were searched using PubMed and tumour characteristics, clinicopathologic features, therapeutic strategy and survival outcomes were reviewed. Of the 5 cases, all were males, with a mean age of 57.6 years (range, 37–68 years). All patients were asymptomatic and were identified incidentally on routine computed tomography examination. A total of 3 patients underwent thoracotomy and 2 patients underwent video-assisted thoracoscopic surgery. All tumours were completely resected. Postoperative haemorrhage occurred in 1 patient and he received surgical intervention for haemostasis. The average hospital stay was 15 (4–22) days, and no mortality occurred. The mean length of the postoperative follow-up was 37.6 (1–67) months. One patient was lost to follow-up, and 4 patients were asymptomatic. A total of 19 studies were identified from database searches. They included a total of 45 patients: Twenty-three males and 22 females (mean age, 59.4 years; range, 7–81 years). A total of 12 patients were asymptomatic, and pain and coughing were the major symptoms. Five, one, two, four, and 17 tumours occurred in the right upper lobe, right middle lobe, right lower lobe, left upper lobe and left lower lobe, respectively. A total of 39 patients underwent surgery, 1 patient underwent radiotherapy, and 1 patient underwent radiofrequency ablation. A total of 22 patients were followed up and the mean length of the postoperative follow-up was 48 (1–168) months. One patient was diagnosed with chest wall metastases, and 5 patients succumbed to mortality. To conclude, primary intrapulmonary SFTs are extremely rare and typically identified incidentally. The present findings indicated that the left lower lobe was the most common site location and complete surgical resection is a safe and effective treatment.

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Primary intrapulmonary solitary fibrous tumours

et al. 2018

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“…Based on the new World Health Organization (WHO) classification of tumors of the CNS published in 2007 and WHO classification of tumors of soft tissue and bone published in 2013, necessary criterions suggestive of the malignant potential of SFTs include hypercellularity, more than 4 mitoses/10 HPFs, variable cytological atypia, tumor necrosis, and/or infilitrative margins, among which mitoses seem to be most prognostic [ 2 , 19 ]. Some pathologists have suggested that the size of a SFT (bigger than 10cm) is one of the best indicators of malignancy [ 20 ]. Currently, there are no criteria for determining malignancy with tumor size in cerebral SFTs.…”

Section: Discussionmentioning

confidence: 99%

Rapid recurrence and bilateral lungs, multiple bone metastasis of malignant solitary fibrous tumor of the right occipital lobe: report of a case and review

Yang

Weng

et al. 2015

Diagn Pathol

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BackgroundIntracranial malignant solitary fibrous tumor (MSFT) is extremely rare. The authors report a case of MSFT of the right occipital lobe with a rapid recurrence and bilateral lung, multiple bone metastasis.Case presentationThe patient was a 25-year-old male presenting with headache, nausea and visual disturbances without obvious cause. Three times right-side occipital craniotomies were performed and two times postoperative conformal radiotherapy were administered within one year. 4 months after the third time of right-side occipital craniotomy, the patient felt right chest pain and neck pain. Positron emission tomography/computed tomography (PET/CT) showed tumor recurrence of the right occipital lobe and bilateral lung metastasis, multiple bone metastasis including: vertebrae, libs, the left iliac wing, sacrum, the right ischium and upper parts of both femurs. Ultrasound guided puncture biopsy of left-side back of the neck and CT guided puncture biopsy of the third lumbar vertebra were performed. General sample showed grayish white or grayish red with irregular shape. Histopathologically, the tumor was composed of areas of alternating hypercellularity and hypocellularity with spindle-shaped cells, which arranged as fascicular, storiform pattern or patternless pattern, with intervening irregular eosinophilic collagen bundles. Some areas showed hemangiopericytoma-like perivascular pattern and perivascular hyalinization. Tumor cells were pleomorphic with mitotic counts of more than 4 per 10 high power fields and showed coagulative necrosis. Immunohistochemically, tumor cells were diffusely positive for vimentin and CD99, focal positive for CD34, bcl-2 and Actin. Ki-67 labelling index was more than 40 %. The final pathological diagnosis was MSFT of the right occipital lobe, metastatic MSFT of left-side back of the neck and the third lumbar vertebra.ConclusionThe MSFT of the right occipital lobe with recurrence and bilateral lung, multiple bone metastasis is extremely rare. Although intracranial MSFT is extremely rare, it should be considered in the differential diagnosis. Definite diagnosis depended mainly on pathological morphology and immunohistochemistry. The prognosis of MSFT is poor due to recurrence and metastasis. Complete resection of intracranial MSFT is difficult, and carful follow-up is needed.

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“…Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that account for less than 2% of all soft tissue neoplasms [1]. Furthermore, they also have an age adjusted incidence rate of 0.061 per 100,000 people per year [2].…”

Section: Introductionmentioning

confidence: 99%

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

Janik,

Terlecka,

Spałek

et al. 2023

Cancers

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Solitary fibrous tumors (SFT) are rare mesenchymal neoplasms that account for less than 2% of all soft tissue masses. In the latest WHO 2020 Classification of Soft Tissue Tumors, extrameningeal SFT was listed as intermediate (rarely metastasizing) or malignant neoplasms. Due to the lack of characteristic clinical features, their diagnosis and treatment remain challenging. The pathogenesis of SFT is often associated with the presence of fusions of the NAB2-STAT6 gene on the 12q13 chromosome. Cytoplasmic CD34 positive staining is considerably characteristic for most SFTs; less frequently, factor XII, vimentin, bcl-2, and CD99 are present. A key factor in the diagnosis is the prevalent nuclear location of STAT6 expression. Radical resection is the mainstay of localized SFTs. In the case of unresectable disease, only radiotherapy or radio-chemotherapy may significantly ensure long-term local control of primary and metastatic lesions. To date, no practical guidelines have been published for the treatment of advanced or metastatic disease. Classical anthracycline-based chemotherapy is applicable. The latest studies suggest that antiangiogenic therapies should be considered after first-line treatment. Other drugs, such as imatinib, figitumumab, axitinib, and eribulin, are also being tested. Definitive radiotherapy appears to be a promising therapeutic modality. Since standards for the treatment of advanced and metastatic diseases are not available, further investigation of novel agents is necessary.

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Solitary Fibrous Tumor of the Infratemporal Fossa

Cited by 8 publications

References 13 publications

Primary intrapulmonary solitary fibrous tumours

Primary intrapulmonary solitary fibrous tumours

Rapid recurrence and bilateral lungs, multiple bone metastasis of malignant solitary fibrous tumor of the right occipital lobe: report of a case and review

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

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