Solitary fibrous tumor of the mammary gland: a potential pitfall in breast pathology

Falconieri, Giovanni; Lamovec, Janez; Mirra, Maurizio; Pizzolitto, Stefano

doi:10.1016/j.anndiagpath.2004.03.002

Cited by 34 publications

(32 citation statements)

References 17 publications

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“…Despite they are seldom located in extrapleural soft tissue this tumor has been reported in a variety of extraserosal sites (Ramdial and Madaree 2001). By reviewing the literature following locations are described: lumbar extradural (Donnellan et al 2000), intrameningeal (Nawashiro et al 2000;Kawamura et al 2004), in cervical spine (Obara et al 2003;Bohinski et al 2004), in the deep soft tissue of the neck (Goh et al 2002;Bachmeyer et al 2004), in orbital space (Ahn et al 2001;O'Donovan et al 2002;Schellini et al 2003), in pelvic space (Ishikawa et al 2004), retroperitoneal (Nagasako et al 2004), vaginal (Akiyama et al 2000), in the thyroid gland (Parwani et al 2003;Babouk 2004), in mammary gland (Falconieri et al 2004), in prostate (Ishii et al 2004), in nasal mucosa (Munks 2003), in the liver (Neeff et al 2004), in renal pelvis (Yazaki et al 2001;Magro et al 2002), and in extremities (Akisue et al 2003). All of these tumors are diagnosed and categorized by histology and immunohistochemical patterns.…”

Section: Introductionmentioning

confidence: 93%

Solitary fibrous tumor in the thigh: review of the literature

Anders

Aurich

Lang

et al. 2005

J Cancer Res Clin Oncol

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Solitary fibrous tumors (SFT) of extremities, especially the thighs are very rare. Despite SFTs are generally benign, well-circumscribed soft tissue tumors new cases should be presented and followed up carefully to monitor their biological behavior. In general for tumor classification a biopsy is state of the art. Histological including immunohistochemical patterns for SFTs are defined. MRI and ultrasound are not sufficient for differential diagnosis. Once property identified and defined by size and location, resection with intact tumor capsule may result in full recovery of the patient. Reviewing the literature there are no validated reasons for a wider resection. The current patient was a 41-year-old male. Four years after an arthroscopy of the left knee the patient has been suffering an ongoing swelling of the lateral thigh. Because MRI scan data suggested a synovial sarcoma a biopsy was performed. The tumor was classified as a benign SFT. The diagnosis based on histological findings and the presence of the positive immunohistochemical markers Vimentin, CD34, and CD99. The complete tumor resection with intact capsule was achieved in a final operation. Clinical and in MRI after 54-month outcome period there were no local recurrences.

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Section: Introductionmentioning

confidence: 93%

Solitary fibrous tumor in the thigh: review of the literature

Anders

Aurich

Lang

et al. 2005

J Cancer Res Clin Oncol

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“…Cuando el tumor invade regiones del parénquima pulmonar puede ser necesaria la lobectomía pulmonar [1,20]. Se ha reportado la presencia de tumores con características histopatológicas e inmunohistoquímicas idénticas al tumor fibroso solitario de pleura en localizaciones extratorácicas, entre las cuales se documenta en peritoneo, pared abdominal, meninges, pericardio, órbita, cavidad oral, cavidad nasal, glándula mamaria y salival [22][23][24][25][26][27][28]. El tamaño promedio de este tipo de tumores en el momento de la resección quirúrgica ronda los 8,5 cm [29].…”

Section: Discussionunclassified

Tumor fibroso solitario y gigante de pleura

2010

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Resumen:El tumor solitario de pleura es una patología benigna poco frecuente que representa alrededor del 8% de los tumores intratorácicos. Se presenta el caso clínico de un paciente masculino de 37 años con cuadro de dolor torácico de inicio súbito y disnea. Se documenta una lesión radiopaca en hemitórax derecho. La biopsia por aguja gruesa evidencia la presencia de células tumorales CD34 (+) y Vimentina (+), con marcadores S-100 y citoqueratina negativos. Se realiza toracotomía posterolateral y resección de masa tumoral pediculada de aproximadamente 20 por 15 cm y 1860 g. La recurrencia y potencial de malignización de este tipo de tumores benignos son bajos, por lo que se recomienda un seguimiento radiológico anual postoperatorio.Palabras claves: Tumor, pleura, benigno, inmunohistoquímica, toracotomía. Abstract:Solitary Fibrous Tumors of Pleura are rare and benign clinical entities which represent an 8% of intrathoracic tumors. A clinical case of a 37-year-old patient who referred acute thoracic pain and dyspnea is discused. Chest-x-ray showed a radiopaque lesion localized in the right hemithorax. There were positive immunohystochemical biomarkers in tumoral cells, such as CD34 and Vimentin, whereas S-100 and Cytokeratin were negative in the Tru-Cut biopsy. A posterolateral thoracotomy with pediculated tumor resection was made, describing a 1860 g mass with an approximated diameter of 20x15 cm. Because of usually low recurrence and malignancy potential of these benign tumors, annual radiologic assessment was recommended.http://www.revistamedica.ucr.ac.cr cr 96

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“…15 Other modalities of treatment, such as radiotherapy, hormonal agents, anti-inflammatory agents, and cytotoxic agents may be used in patients with unresectable tumors or tumors that would require extensive resection, including chest wall resection. [14][15][16][17][18][19][20][21][22][23] The reported case demonstrates that fibromatosis in the male breast may have features and a presentation that can be confused with breast cancer. In situations where obvious breast changes and history do not correlate with routine diagnostic measures, the presence of an unusual breast or chest wall tumor such as a fibromatosis should be considered, including this as part of the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Fibromatosis of the Male Breast: A Case Report With Immunohistochemistry Study and Review of the Literature.

Macchetti¹,

Marana²,

Ribeiro‐Silva³

et al. 2006

Clinics

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Fibromatosis is an infiltrative proliferation of fibroblastic and myofibroblastic cells with significant risk for local recurrence, but no metastatic potential.1 It originates mainly from the fascia or aponeuroses of the abdominal wall muscles or from the muscles of the shoulders and pelvic girdles.1 Fibromatosis is uncommon in the mammary gland and accounts for less than 0.2% of all primary breast lesions.2,3 Although several series of this condition have been reported in women, mammary fibromatosis in men is extremely rare. [4][5][6][7] Despite its rarity, this condition may mimic primary breast malignancy. In cases where suspicious breast findings do not correlate with the usual diagnostic measures, such as those from fine-needle aspiration or core needle biopsy, the diagnosis of a fibromatosis mimicking breast cancer should be considered in the differential diagnosis. [8][9] We report the case of a 47-year-old man with mammary fibromatosis. To the best of our knowledge, this is the sixth case of fibromatosis reported in the male breast. [4][5][6][7] The optimal management of breast fibromatosis in men is unknown because of the rarity of the disease. A review of articles published on breast fibromatosis was performed using the PUBMED-MEDLINE database with emphasis on articles published during the last 10 years. CASE REPORTWe present the case of a 47-year-old man who was admitted to the Outpatient Breast Oncology Service, Department of Health of São Carlos, Brazil, with a 3-month history of a painless subcutaneous mass with rapid growth. Clinical examination revealed an ill-defined mass located in the upper inner quadrant of his left breast tissue measuring of 3.5 cm in diameter. The mass was firm and was fixed to the pectoral fascia and to skin. There was no axillary or cervical lymphadenopathy or nipple discharge.At ultrasound, the lesion manifested as an irregular, hypoechoic mass with posterior acoustic shadowing, suggestive of malignancy. Fine-needle aspiration cytology was performed, but the result was inconclusive because the aspirate did not yield sufficient epithelial cells for diagnosis. The tumor was removed by en bloc resection with wide excision, the greater pectoral muscle being spared. During surgery the lesion was found to be firmly adherent to the underlying pectoralis major. The appearance was that of an infiltrative tumor, and the diagnosis of epithelial neoplasm was considered in the differential diagnosis. There was no history of trauma to the chest wall, so that a fibrous reaction to trauma was not considered in the differential diagnosis.The surgical specimen was fixed in 4% formalin. Sequential 3-mm sections were obtained throughout the specimen. Representative samples of the tumor were embedded in paraffin, and histological sections of 4 µm obtained from the paraffin-embedded blocks were stained with hematoxylin-eosin. The histological sections stained with hematoxylin-eosin showed a proliferation of spindle cells without atypia forming sweeping or interlacing fascicles (Figure 1). The...

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Solitary fibrous tumor of the mammary gland: a potential pitfall in breast pathology

Cited by 34 publications

References 17 publications

Solitary fibrous tumor in the thigh: review of the literature

Solitary fibrous tumor in the thigh: review of the literature

Tumor fibroso solitario y gigante de pleura

Fibromatosis of the Male Breast: A Case Report With Immunohistochemistry Study and Review of the Literature.

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