Solitary fibrous tumor of the mediastinum

Abstract

An 18-year-old man was referred to our hospital for further evaluation of a right anterior mediastinal tumor that measured 6 cm in diameter. Computed tomography-guided transcutaneous aspiration biopsy was performed, but no definitive diagnosis could be obtained. Because the tumor did not appear to be a high-grade malignant tumor, we undertook resection of the tumor to obtain a definitive diagnosis and provide appropriate treatment. Total thymectomy with tumor resection was performed through a median sternotomy. The tumor was solid, measuring 5.2 x 4.2 x 3.5 cm. The histological diagnosis was solitary fibrous tumor (SFT) arising from the mediastinum. Most extrathoracic SFTs appear to pursue a benign course, although careful long-term follow-up of these patients is necessary because the tumors have been reported to recur or metastasize in some cases.

Mesenchymal tumours of the mediastinum—part I

“…Other markers typically positive in SFT are CD99 and Bcl2 [ 127 ]. Variable staining is seen with smooth muscle actin, while cytokeratin positivity is very rare [ 163 ], except in variants with epithelioid morphology (see below). Recently, nuclear staining of STAT6 resulting from NAB2-STAT6 gene fusion [ 170 – 172 ] has been shown to be a more specific marker for SFT [ 173 – 175 ], although presence of the NAB2-STAT6 gene fusion has not yet been formally shown for mediastinal SFT.…”

Clinical and pathological analysis of solitary fibrous tumors with portal vein widening

“…[5] The tumor usually becomes apparent when compression symptoms become apparent. [6] There was no gender difference in SFTs. SFTs can occur almost anywhere in the body but is common in areas such as the pleura, pericardium, meninges, peritoneum, and so on.…”

Computed tomography of solitary fibrous tumor of the pleura abutting the mediastinum: A diagnostic challenge

“…Relating to the contrast medium, all mediastinal tumors as thymic neoplasms, disembriogenetic tumors or lymphomas may show cystic or necrotic degeneration with heterogeneous enhancement not allowing a differential diagnosis on radiologic appearances alone. [ 15 16 17 ]…”