Solitary fibrous tumor of pleura (symptoms, diagnosis, treatment)

Salimov, Z.M.; Пикин, О. В.; Ryabov, А. B.; Popov, M.I.; Кононец, П. В.; Волченко, Н. Н.; Blinov, D A; Nikulin, K A

doi:10.17116/hirurgia202008135

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…Both the SFT and hemangiopericytoma (HPC) showed 12q13 inversion and NAB-2 and STAT-6 gene fusion. The two were combined into “SFT/HPC” in the 2016 WHO central nervous system tumor classification [ 1 , 2 ]. SFTP is a rare neoplasm that accounts for less than 5% of primary pleural tumors.…”

Section: Discussionmentioning

confidence: 99%

Resection of giant malignant solitary fibrous pleural tumor after interventional embolization: a case report and literature review

Yao

Zhu

Wang

et al. 2022

J Cardiothorac Surg

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Background Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal tumor that arises at various sites and typically originates from the pleura. Most patients with SFTPs are asymptomatic, unless the tumor is large. Approximately 20% of SFTP cases are malignant. There are few reports on imaging diagnoses and interventional treatments of SFTP. Here, we report a case of a giant SFTP that exhibited malignant behavior and underwent successful resection after embolization of the main supply artery of the tumor. Case presentation We report a clinical case of a giant SFTP in a 66-year-old Chinese female patient complaining of chest tightness and cough for more than 2 months. Ten years ago, the patient had undergone a chest CT scan at a local hospital for cough. Computed tomography (CT) had revealed a mass in the right thoracic region, which was misdiagnosed as a pulmonary abscess by CT-guided biopsy. Therefore, the patient did not receive appropriate/complete treatment at that time. She was hospitalized again, because CT showed significant enlargement of the right thoracic mass, which caused her obvious symptoms of discomfort. The pathological results of CT-guided biopsy at our hospital confirmed SFTP. Considering the large size of the tumor and the rich blood supply, some of the main blood vessels were treated with embolization before surgical resection. A large tumor, about 23 cm × 16 cm × 15 cm in size, was then successfully removed by thoracic surgery. The diagnosis of malignant SFTP was confirmed by surgical pathology and immunohistochemistry. Conclusion Imaging findings of SFTPs are not characteristic, especially when a tumor is large, the diagnosis is difficult, and the final diagnosis still depends on histological and immunohistochemical examinations. The two-stage surgical treatment described here, which involves first embolization of the main supplying artery of the large tumor and then complete surgical resection, is effective and safe for SFTPs. Whether needle biopsy or vascular embolization is performed, intervention plays a crucial role in the diagnosis and treatment of patients with SFTPs.

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Section: Discussionmentioning

confidence: 99%

Resection of giant malignant solitary fibrous pleural tumor after interventional embolization: a case report and literature review

Yao

Zhu

Wang

et al. 2022

J Cardiothorac Surg

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“…Both SFT and hemangiopericytoma (HPC) showed 12q13 inversion, NAB-2 and STAT-6 gene fusion. The two were combined as SFT/HPC in 2016 WHO central nervous system tumor classi cation [1,2] . SFTP is a rare neoplasm accounting for less than 5% of primary pleural tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Author details 1 Department of Radiology, A liated Hospital of Shaoxing University (The Shaoxing Municipal Hospital), Shaoxing 312000, Zhejiang Province, China. 2 Medical college of Shaoxing University, Shaoxing 312000, Zhejiang Province, China.…”

Section: Abbreviationsmentioning

confidence: 99%

Resection Of Giant Malignant Solitary Fibrous Pleural Tumor After Interventional Embolization: A Case Report And Literature Review

Yao

Zhu

Wang

et al. 2022

Preprint

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Background: Solitary fibrous tumor of the pleura (SFTP) is rare mesenchymal tumors that arise at a variety of sites and typically originate from the pleura. Most patients of SFTP are usually asymptomatic unless the tumor is large. Only about 20% of SFTP cases are malignant. There were few reports about the imaging diagnosis and interventional treatment of SFTP. We here in report a case of giant SFTP, which exhibited malignant behavior and underwent a successful resection after embolization of the main supply artery of the tumor.Case presentation: We report a clinical case of giant SFTP in a 66-year-old Chinese female patient complaining of chest tightness and cough for more than two months. Ten years ago, the patient had a chest CT scan at the local hospital for a cough. The CT scan revealed a mass on the right thoracic,which was misdiagnosed as a pulmonary abscess by a CT-guided biopsy. So the patient was not received the correct and complete treatment at that time. She was hospitalized again because of CT showed a significant enlargement of the right thoracic mass, which caused obvious symptoms of discomfort. The pathological results of CT-guided biopsy in our hospital confirmed SFTP. Considering the large size of the tumor and rich blood supply, part of the main blood vessels were treated with embolization firstly before surgical resection. Then, a large tumor with a size of about 23cm×16cm×15cm was successfully removed by thoracic surgery. The diagnosis of malignant SFTP was confirmed by surgical pathology and immunohistochemistry.Conclusion: The imaging findings of SFTP are not characteristic, especially when the tumor is large, the diagnosis is difficult, and the final diagnosis still depends on histological and immunohistochemical examination. This two-stage surgical treatment, which involves first embolization of the main supplying artery of the large tumor and then complete surgical resection of the tumor, is effective and safe for SFTP. Whether needle biopsy or vascular embolization, intervention plays a crucial role in the diagnosis and treatment of patients with SFTP.

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“…Fibroblastic tumors include a variety of tumors based on the World Health Organization (WHO) classi cation of soft tissue tumors [1,2], and among them, intermediate and malignant lesions have attracted attention due to their high local invasiveness and recurrence rate, the common tumors being desmoid-type bromatosis, dermato brosarcoma protuberans, in ammatory myo broblastic tumor, SFT, myxo brosarcoma, and high-grade brosarcoma, which often grow rapidly [3][4][5]. The most likely explanation is that these tumors often exhibit a multinodular in ltrative growth pattern and tend to in ltrate widely into surrounding tissues [4].…”

Section: Introductionmentioning

confidence: 99%

Head‑to‑head assessment of 68Ga-DOTA-FAPI-04 PET/CT vs 18 F-FDG PET/CT in fibroblastic tumors

Zhang

Meng

yao

et al. 2022

Preprint

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Purpose: We aimed to evaluate 68Ga-DOTA-FAPI-04 PET/CT versus 18F-FDG PET/CT in the application of fibroblastic tumors.Methods: Twenty patients with 6 subtypes of fibroblastic tumors prospectively underwent 18F-FDG and 68Ga-DOTA-FAPI-04 PET/CT examinations to evaluate the lesions. PET/CT findings were confirmed by surgical pathology, puncture biopsy, or imaging follow-up. Two independent sample t tests were used to compare the uptake of 18F-FDG vs. 68Ga-DOTA-FAPI-04 in primary, recurrent and metastatic lesions. One-way ANOVA was used to compare the uptake of 18F-FDG or 68Ga-DOTA-FAPI-04 among primary, recurrent, and metastatic lesions. The uptake of 68Ga-DOTA-FAPI-04 vs. 18F-FDG in different histopathological lesions was compared by two independent sample t tests.Results: Twenty patients were finally confirmed to have 38 lesions. Although there was no significant difference in the detection of all lesions between 68Ga-DOTA-FAPI-04 and 18F-FDG PET/CT (38 vs. 36, p=0.493), the uptake of 68Ga-DOTA-FAPI-04 in lesions was significantly higher than that of 18F-FDG (p<0.001), including primary (p<0.001), recurrent (p=0.018) and metastatic (p<0.001) lesions. The SUVmax of 68Ga-DOTA-FAPI-04 in primary and recurrent lesions was higher than that in metastasis (p=0.034 and p=0.015, respectively). The SUVmax of 68Ga-DOTA-FAPI-04 in primary and recurrent malignant lesions was significantly higher than that of the intermediate (p<0.001). The SUVmax of 18F-FDG in solitary fibrous tumors (SFTs) was significantly lower than that in non-SFT lesions (p=0.029). The SUVmax of 68Ga-DOTA-FAPI-04 in one case of recurrent SFT with 5 lesions was significantly lower after treatment than before treatment (p =0.016).Conclusion: 68Ga-DOTA-FAPI-04 outperformed 18F-FDG PET/CT in displaying the primary, recurrent and metastatic lesions of fibroblastic tumors. 68Ga-DOTA-FAPI-04 PET/CT may also show potential value for judging the nature and monitoring the therapeutic response of tumors.

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Solitary fibrous tumor of pleura (symptoms, diagnosis, treatment)

Cited by 5 publications

References 10 publications

Resection of giant malignant solitary fibrous pleural tumor after interventional embolization: a case report and literature review

Resection of giant malignant solitary fibrous pleural tumor after interventional embolization: a case report and literature review

Resection Of Giant Malignant Solitary Fibrous Pleural Tumor After Interventional Embolization: A Case Report And Literature Review

Head‑to‑head assessment of 68Ga-DOTA-FAPI-04 PET/CT vs 18 F-FDG PET/CT in fibroblastic tumors

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