Solitary fibrous tumor arising in the mesentery: a case report

Bouhabel, Sarah; Leblanc, G; Ferreira, José; Leclerc, Yves; Dubé, Pierre; Sidéris, Lucas

doi:10.1186/1477-7819-9-140

Cited by 18 publications

(13 citation statements)

References 12 publications

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“…The immunohistochemical study also did not show any reactivity for SMA or S-100, eliminating the possibility of leiomyosarcoma and peripheral nerve sheath tumor. Myofibroblastic tumor usually shows focal myxoid stroma and is normally CD34 negative [14]. Hemangiopericytoma is known to have a histopathological and immunohistochemical overlap, and it is questionable if it can be clearly distinguished from SFT.…”

Section: Case Reportmentioning

confidence: 99%

A hypervascular malignant solitary fibrous tumor in the mesentery of the rectum with good response to preoperative radiation therapy

Nishikawa

Takei²,

Teshima³

et al. 2012

Int Canc Conf J

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Solitary fibrous tumor (SFT) is an uncommon neoplasm located in the pelvis. Here, we report a case of hypervascular malignant SFT in the mesentery of the rectum that showed a significant response to preoperative radiotherapy. A 36-year-old man presented to our department with constipation and dysuria. Abdominal computed tomography confirmed a large round neoformation (155 mm in the longest diameter) with an evident contrastenhanced periphery and a central necrotic area in the pelvis. Considering the results of the examinations, a pelvic neoplasm was strongly suspected. Due to the difficulty of safe gross total removal, a diagnostic laparotomy was indicated. Histologically, hypercellularity with spindleshaped cells and high mitotic activity was observed. Immunohistochemically, the tumor was positive for CD34, CD99, and bcl-2. The diagnosis of hypervascular malignant SFT was made. After the appropriate information had been given, the patient chose the use of preoperative radiotherapy. After local irradiation, the tumor size regressed to 105 mm in the longest diameter. Laparotomy revealed a tumor originating from the mesentery of the rectum, and the tumor was successfully excised. This case strongly suggested the potential applicability of preoperative radiotherapy for the safe gross total removal of a large pelvic SFT.

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Section: Case Reportmentioning

confidence: 99%

A hypervascular malignant solitary fibrous tumor in the mesentery of the rectum with good response to preoperative radiation therapy

Nishikawa

Takei²,

Teshima³

et al. 2012

Int Canc Conf J

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“…SFTs can recur for up to 24 years [22]. SFTs mainly spread through the blood stream and the most common metastatic sites are the lungs, liver, and bone [22]. According to Bouhabel, tumors >50 mm, with dense cellularity, pleomorphism in the nucleus, mitotic activity (>4 in 10 high-power fields), anaplasia, necrosis, and hemorrhage are mostly malignant [22].…”

Section: Discussionmentioning

confidence: 99%

“…In our case, the patient was 71 years old (>55), tumor size was 15 cm, and the tumor had one mitotic figure per high-power field, so he fell in the high risk group. SFTs can recur for up to 24 years [22]. SFTs mainly spread through the blood stream and the most common metastatic sites are the lungs, liver, and bone [22].…”

Section: Discussionmentioning

confidence: 99%

A Case of Solitary Fibrous Tumor of the Mesorectum: Usefulness of Immunohistochemical Staining for a Differential Diagnosis from a Gastrointestinal Stromal Tumor

Nagasawa¹,

Tatsuta²,

Ki³

et al. 2017

Journal of Cancer science and Clinical Oncology

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Extrapleural solitary fibrous tumors (SFT) and gastrointestinal stromal tumors (GISTs) are similar morphologically and on imaging studies. We report a case of a patient with a giant pelvic tumor, which was difficult to be diagnosed. A 71-year-old male presented to our hospital with a complaint of urinary retention. A radiological examination showed a giant pelvic tumor mass, which ventrally compressed the urinary bladder and rectum, and was supplied by vascular flow from the right internal iliac artery. The resected specimen was 15 × 10 cm, elastic soft, and solid pale yellow in color. Because the tumor was histologically composed of spindle-shaped cells and was CD34 positive, cytokeratin negative, epithelial membrane antigens negative and KIT negative, we first thought the tumor was a KIT-negative GIST. However, additional immunohistochemical staining was DOG1-negative but CD99 and bcl-2 positive. Therefore, we finally diagnosed the patient with SFT. In conclusion, we report a rare case of SFT of the mesorectum to emphasize the importance of bearing this entity in mind and to show that immunohistochemical staining is useful for differentiating this type of tumor from other spindle cell neoplasms, particularly GISTs.

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“…The Solitary Fibrous Tumor (SFT) is an unusual spindle cell neoplasm first described in the pleura, in 1870, by Wagner. 1 Postulated cells of origin comprise of fibroblasts, myofibroblasts, endothelial cells, as well as pericytes. 2 This type of tumour usually arises from pleura but has recently been described in diverse extrapleural sites like upper respiratory tract, lung, nasal cavity, paranasal sinuses, orbits, mediastinum, major salivary glands, breast, meninges, liver and urogenital organs.…”

Section: Introductionmentioning

confidence: 99%

A Rare Solitary Fibrous Tumour of Kidney

Pathak

Nepal

2013

J Nepal Med Assoc

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A solitary fibrous tumour (SFT) is an unusual spindle cell neoplasm. It frequently arises from the serosal surface of pleural cavity but has recently been described in diverse extrapleural sites. Urogenital localization is rare and only 36 cases of SFTs of the kidney have been described on published report. We report a case of a large SFT clinically and radiologically thought to be renal cell carcinoma arising in the kidney of a 30- year-old female. The radical nephrectomy was performed. The tumour was a well- circumscribed, solid mass attached to the renal pelvis without necrosis and haemorrhage. Histopathologically, a spindle cell neoplasia with alternating hypo and hypercellular areas, storiform, fascicular and hemangipericytoma- like growth pattern and less cellular dense collagen deposits were observed. Immunohistochemical studies revealed reactivity for CD34, CD99 and Bcl-2 protein.

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Solitary fibrous tumor arising in the mesentery: a case report

Cited by 18 publications

References 12 publications

A hypervascular malignant solitary fibrous tumor in the mesentery of the rectum with good response to preoperative radiation therapy

A hypervascular malignant solitary fibrous tumor in the mesentery of the rectum with good response to preoperative radiation therapy

A Case of Solitary Fibrous Tumor of the Mesorectum: Usefulness of Immunohistochemical Staining for a Differential Diagnosis from a Gastrointestinal Stromal Tumor

A Rare Solitary Fibrous Tumour of Kidney

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