Solitary extranodal lymphoma of sciatic nerve

Purohit, Dushyant P.; Dick, D J; Perry, Robert H.; Lyons, Paul; Schofield, Ian; Foster, John Burt

doi:10.1016/0022-510x(86)90188-7

Cited by 54 publications

(33 citation statements)

References 14 publications

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“…26 All patients presented with sensory and motor impairment in the distribution of the affected nerve. All but three of the patients 26,46,47 reported pain in the involved extremity. The six previously reported patients included four men and two women, ranging in age from 34 to 72 years (median age, 62.5 yrs).…”

Section: Discussionmentioning

confidence: 97%

“…13,24,26,43,46,47 Five of the cases involved the sciatic nerve 13,24,43,46,47 and one involved the median nerve. 26 All patients presented with sensory and motor impairment in the distribution of the affected nerve.…”

Section: Discussionmentioning

confidence: 99%

“…13,24,26,43,46,47 We present an additional four cases of primary lymphoma of peripheral nerves to help promote better understanding of the biologic behavior of this rare form of lymphoma.…”

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confidence: 97%

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Primary Lymphoma of Peripheral Nerve

Misdraji

Ino

Louis

et al. 2000

The American Journal of Surgical Pathology

106

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Lymphoma presenting as a solitary tumor of peripheral nerve is exceedingly rare, with only six previously reported cases. The authors describe an additional four cases of primary lymphoma of peripheral nerve involving the sciatic nerve (two cases), the radial nerve, and the sympathetic chain and spinal nerve. The patients were two men and two women with an average age of 55.5 years. All tumors were high-grade B-cell lymphomas. Two patients experienced relapse of disease with involvement of other nervous system sites and died of lymphoma. One patient is alive with stable local disease at 57 months. The fourth patient is alive with no evidence of disease at 54 months. Expression of neural cell adhesion molecule (CD56) has been reported to correlate with an increased incidence of central nervous system involvement in peripheral T-cell lymphoma; all their cases were CD56 negative. Recent reports indicate a high proportion of primary brain lymphomas show loss of CDKN2A/p16 gene expression. Therefore, CDKN2A/p16 was evaluated in their patients both by polymerase chain reaction and by immunohistochemistry for the p16 protein. The authors found homozygous deletion of the CDKN2A/p16 gene in one of three patients studied, confirmed immunohistochemically by absent staining for p16. The fourth patient showed absent staining for p16, suggesting inactivation of the gene in this case as well. The two patients with p16 loss both died of lymphoma, whereas the two patients with normal p16 expression are alive. Primary lymphoma of peripheral nerve is a rare neoplasm, usually of large B-cell type, has a variable prognosis, and appears to have less consistent loss of p16 expression than primary central nervous system lymphoma.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Primary Lymphoma of Peripheral Nerve

Misdraji

Ino

Louis

et al. 2000

The American Journal of Surgical Pathology

106

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“…106,138 Endoneurial infiltrates are associated with a mix of segmental demyelination and axonal degeneration by mechanisms that are unclear. 89,106,138 The pathology may, in some cases, resemble Marek's disease in chickens, which is a well studied T-cell lymphoma affecting only peripheral nerves, caused by avian cytomegalovirus infection. 80,87 However, most infiltrative neuropathies in humans are due to B-cell lymphoma.…”

Section: Pathogenesis Of Lymphomatous Neuropathymentioning

confidence: 99%

Lymphoma and peripheral neuropathy: A clinical review

2004

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Lymphoma occasionally affects the peripheral nervous system. When it does, the diagnosis can be elusive since many patients present without known lymphoma. Most peripheral nerve complications are due to non-Hodgkin's lymphoma (NHL), which infiltrates nerves causing axonal damage. This disorder can affect nerve roots and cranial nerves, often associated with lymphomatous meningitis. NHL may also infiltrate peripheral nerves and cause plexopathy, mononeuropathy, or generalized neuropathy. These neuropathies may resemble an asymmetric mononeuropathy multiplex or a generalized disorder such as chronic inflammatory demyelinating polyradiculoneuropathy. When NHL infiltrates diffusely, the term neurolymphomatosis is used. Hodgkin's lymphoma (HL), by contrast, rarely infiltrates nerves. More often, HL causes immunological disorders of the peripheral nervous system such as inflammatory plexopathy or Guillain-Barré syndrome. Other rare lymphomas such as intravascular lymphoma and Waldenstrom's macroglobulinemia can also affect peripheral nerves in specific ways. In addition, other malignant and nonmalignant lymphoproliferative disorders enter into the differential diagnosis of lymphomatous neuropathy. This review discusses the multiple peripheral nerve presentations of lymphoma from the clinician's point of view and provides a guide to the evaluation and diagnosis of these uncommon, challenging disorders.

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“…It was rather surprising that there was no other peripheral nerve involvement; Purohit et al [9] reported sciatic nerve involvement in a patient with a non-Hodgkin lympho ma.…”

Section: Discussionmentioning

confidence: 99%