Solitary Extra-axial Intracranial Primary Meningeal Pleomorphic Xanthoastrocytoma: An Extremely Rare Case

Dadhich, Hrishikesh; Sharma, Ravi; Borkar, Sachin A; Dash, Atmanranjan; Mahajan, Shalvi; Sharma, Mehar Chand

doi:10.1016/j.wneu.2019.06.218

Cited by 3 publications

(4 citation statements)

References 44 publications

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“…PMG may occur as a solitary mass or as diffuse meningeal involvement. We reviewed the relevant literature and identi ed only 31 cases of a solitary meningeal glial mass reported in English literature (3). Most PMG were astrocytomas (53.3%) followed by glioblastomas (30%) (3,4).…”

Section: Discussionmentioning

confidence: 99%

“…We reviewed the relevant literature and identi ed only 31 cases of a solitary meningeal glial mass reported in English literature (3). Most PMG were astrocytomas (53.3%) followed by glioblastomas (30%) (3,4). To our knowledge, we are presenting the fourth case of an extra-axial PXA (Table ).…”

Section: Discussionmentioning

confidence: 99%

“…The solid component typically appears hypo to isodense, but can occasionally be hyperdense, with areas of calci cation seen in the solid component (1). However, it can be presented as a super cial mass with leptomeningeal contact (3,5). Therefore, these tumors should be considered as a differential diagnosis of intracranial meningiomas.…”

Section: Discussionmentioning

confidence: 99%

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Primary meningeal pleomorphic xanthoastrocytoma: Case report and review of literature

Maamri

Taieb

Boukhit

et al. 2022

Preprint

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Pleomorphic xanthoastrocytoma (PXA is a rare low-grade glial neoplasm of the central nervous system accounting for less than 1% of all astrocytomas. Similar to other gliomas, it can rarely arise from glial nests in the meninges, manifesting as an extra-axial mass mimicking a meningioma.In this article, we report the fourth case, so far, of a solitary primary meningeal PXA in a 23-year-old woman who presented with temporal seizures and features of raised intracranial pressure.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary meningeal pleomorphic xanthoastrocytoma: Case report and review of literature

Maamri

Taieb

Boukhit

et al. 2022

Preprint

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“…The clinical symptoms mainly consist of epilepsy. There have also been reports of cases of PXA in other regions, including the cerebellum, [3][4][5] spinal cord, 6 tectorial area, 7 meninges, 8 and retina. 9 Electron microscopy studies have found bidirectional differentiation of glial neurons, as well as expression of CD34 and other neuronal cell markers, in PXA cases.…”

Section: Discussionmentioning

confidence: 99%

<p>Anaplastic Pleomorphic Xanthoastrocytoma: A Case Report and Literature Review</p>

Liu¹,

Sun²,

Liu³

2020

IJGM

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Background With an incidence of less than 1% among astrocytomas, pleomorphic xanthoastrocytoma (PXA) is rare. When its mitotic activity exceeds 5 mitoses/10 high-power fields, PXA is defined as anaplastic pleomorphic xanthoastrocytoma (APXA). This report documents the clinical manifestations and histopathological characteristics of APXA to help prevent future misdiagnoses. Case Presentation A 28-year-old male patient had a sudden limb twitch and visited a local hospital. A head magnetic resonance imaging scan showed large patches of abnormal signal intensity that were approximately 6.0×3.3 cm in size in the right frontal and parietal lobes, with iso- to slightly hypointense signals on T1-weighted images (T1WI) and mixed hyperintense signals on T2-weighted images (T2WI). Optical microscopic imaging found pleomorphic tumor cells with sheet-like growth, as well as foamy tumor cells, multinucleated giant cells, pleomorphic cells with atypical nuclei, and acidophilic bodies. Some areas were densely packed with obvious atypia and visible mitoses. The patient tested positive for glial fibrillary acidic protein (GFAP), vimentin (Vim), neuronal nuclear antigen (NeuN), P53, oligodendrocyte transcription factor-2 (OLIG-2), and ATRX, while he tested negative for synaptophysin (Syn), CD34, S-100, BRAF V600E, and IDH1 R132H. The Ki-67 labeling index was 15%. Genetic sequencing showed that IDH1 and IDH2 genes were wild-type, but that his BRAF gene harbored the V600E mutation. Conclusion APXA is a WHO grade III astrocytoma that can be distinguished from WHO grade II PXA according to the level of mitosis. Imaging may help to inform the difficult differentiation between APXA and epithelioid glioblastoma. Nonetheless, a clear diagnosis warrants carrying out a comprehensive analysis, including histomorphological, immunophenotypic, and molecular assessments.

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Extra-Axial Anaplastic Pleomorphic Xanthoastrocytoma Mimicking Meningioma: A Case Report with Literature Review

Stitou,

Zahir,

Hmamouche

et al. 2024

OJMN

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Solitary Extra-axial Intracranial Primary Meningeal Pleomorphic Xanthoastrocytoma: An Extremely Rare Case

Cited by 3 publications

References 44 publications

Primary meningeal pleomorphic xanthoastrocytoma: Case report and review of literature

Primary meningeal pleomorphic xanthoastrocytoma: Case report and review of literature

<p>Anaplastic Pleomorphic Xanthoastrocytoma: A Case Report and Literature Review</p>

Extra-Axial Anaplastic Pleomorphic Xanthoastrocytoma Mimicking Meningioma: A Case Report with Literature Review

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