Solitary congenital indeterminate cell histiocytoma

Levisohn, D.

doi:10.1001/archderm.129.1.81

Cited by 21 publications

(29 citation statements)

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“…We have been able to identify 24 patients with ICH in the literature, [12][13][14][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] but fear this list is incomplete because of the lack of uniformity in terminology. We tried to compare published evidence to our findings.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, we found relatively more childhood patients. [19][20][21][22][23][24][25][26] We speculate that such patients are more extensively evaluated in order to exclude LCH, and thus identified and published more frequently. On the other hand, fewer solitary lesions in adults have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Sometimes, ICH clinically closely resembles LCH. 21 However, histopathology usually clearly defines these two entities. LCH usually features characteristic kidney-shaped cells and frequently shows epidermal involvement as well as a looser, oedematous stroma.…”

Section: Discussionmentioning

confidence: 99%

“…On the one hand, LCH may in due course lose Birbeck granules (very late stages of LCH may completely lose LC and then consist mainly of xanthomatized macrophages) and such cases may account for rare patients with ICH. 21 On the other hand, macrophage disorders have a polymorphous presentation (Table 1), 10 which also includes their immunoprofile (Table 4). NLCH (XG family) may show aberrant S-100 protein reactivity which when prominent seems to represent the main bulk of ICH lesions.…”

Section: Discussionmentioning

confidence: 99%

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Indeterminate cell histiocytosis: fact or fiction?

et al. 2005

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Indeterminate cell histiocytosis is a rare disorder, in which the predominant cells have the characteristics of both Langerhans cells and macrophages. We, in this study, describe 18 patients and compare them with those previously published. Most patients were adults with either solitary or multiple red-brown papules or nodules. While most lesions were confined to the skin, both conjunctival and bony involvement was seen. Histologically, the lesions showed patterns resembling those described for xanthogranulomas, with predominantly oncocytic (nine patients), spindled (five patients), scalloped (two patients) or vacuolated (two patients) macrophages. The accompanying infiltrate was mainly lymphocytic, although eosinophils and occasionally plasma cells were seen. All lesions were positive for macrophage markers, such as KP1 (CD68) and Ki-M1p, as well as for S-100 protein and showed variable reactivity for CD1a. No Birbeck granules were seen ultrastructurally in one patient. Some patients shared features with sinus histiocytosis with massive lymphadenopathy. It is unclear whether this disorder is a separate entity or represents various macrophage disorders identified at various time points in the inflammatory response. Ratzinger G, Burgdorf WHC, Metze D, Zelger BG, Zelger B. Indeterminate cell histiocytosis: fact or fiction? A clinicopathological series of 18 patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Indeterminate cell histiocytosis: fact or fiction?

et al. 2005

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“…ICs resemble Langerhans cells (LCs) histologically and immunocytochemically, but do not contain any Birbeck granules and are CD207/langerin negative. [1][2][3][4] The origin of ICs is still debated; unlike LCs, which usually acquire Birbeck granules as they transit from dermal to epidermal sites, 5 ICs are thought to be LC precursors arrested during the process of migration and maturation, 6 or 'veiled cell' members of the dermal/epidermal dendritic cell system that migrate from the skin to regional lymph nodes. 1 On the basis of this hypothesis, ICH can be considered a disorder due to locally arrested dermal ICs proliferating before departing for the lymph nodes.…”

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confidence: 99%

Indeterminate cell histiocytosis in association with later occurrence of acute myeloblastic leukaemia

et al. 2007

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Indeterminate cell histiocytosis (ICH) is a proliferation of indeterminate CD1a+, CD68+, S100+ and CD207- dermal dendritic cells. We describe a 39-year-old man who developed diffuse ICH and, 6 years later, acute myeloblastic leukaemia (AML). He was treated with cyclophosphamide, etoposide and vinblastine until 2003. In August 2004, he presented dyspnoea, hyperpyrexia and infiltration of the lung parenchyma, compatible with an AML invasion, and died after a course of induction chemotherapy. Cytomorphology and immunophenotype analyses suggested an ICH clonal evolution. The leukaemogenic role of etoposide is discussed. ICH has previously been reported in association with B-cell malignancy, but only one case has shown systemic progression.

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Unusual variants of non-Langerhans cell histiocytoses

Caputo¹,

Marzano²,

Passoni³

et al. 2007

Journal of the American Academy of Dermatology

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Histiocytic syndromes represent a large, heterogeneous group of diseases resulting from proliferation of histiocytes. In addition to the classic variants, the subset of non-Langerhans cell histiocytoses comprises rare entities that have more recently been described. These last include both forms that affect only the skin or the skin and mucous membranes, and usually show a benign clinical behavior, and forms involving also internal organs, which may follow an aggressive course. The goal of this review is to outline the clinical, histologic, and ultrastructural features and the course, prognosis, and management of these unusual histiocytic syndromes.

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Solitary congenital indeterminate cell histiocytoma

Cited by 21 publications

References 0 publications

Indeterminate cell histiocytosis: fact or fiction?

Indeterminate cell histiocytosis: fact or fiction?

Indeterminate cell histiocytosis in association with later occurrence of acute myeloblastic leukaemia

Unusual variants of non-Langerhans cell histiocytoses

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