Solitary Breast Metastasis From Thyroid Papillary Carcinoma Revealed on Whole-Body Radioactive 131I Scan

Abstract

Breast metastasis from thyroid papillary carcinoma is an exceptional situation. Here, we present the diagnostic approach and the management of a 19-year-old woman with single breast metastasis from thyroid carcinoma. There was no extra thyroidal extension, neoplastic emboli, or lymph node invasion. The metastasis was revealed by whole-body radioactive 131I scan, explored by a fine-needle aspiration, and confirmed by elevated thyroglobulin in situ.

False-Positive 131I Uptake After Transareola Endoscopic Thyroidectomy in a Patient With Papillary Thyroid Carcinoma

“…2,3 In our case, 131 I uptake in the periareolar incision is more likely related to inflammation of local injury, based on short time postsurgical operation, poor incision healing, strict no-tumor principle of the operation, and imaging features. 4,5 Accumulation of 131 I in the breast could be due to various etiologies, including breast tumor, 6 breast fibroadenoma, 7 breast fat necrosis, 8 breast augmentation, 9 drug-related uptake, 10 gynecomastia, 11 and lactation. 12 This case demonstrates that with the increasing application of endoscopic thyroidectomy, the inflammation of local injury should be included in the differential diagnosis of a chest wall 131 I uptake.…”

Diagnosis and Treatment of Acute Pleural Effusion following Radioiodine Remnant Ablation Post Lobectomy for Thyroid Cancer

“…Owing to the improvement of diagnostic accuracy by incorporating hybrid SPECT/CT in the last two decades, most causes of 131 I uptake in rare clinical settings could be identified, with incremental value in the management of patients with DTC, as previously described by our group [ 23 , 24 ]. Recently, extremely scarce cases of solitary breast metastasis from DTC and transplantation in endoscopic thyroidectomy were reported [ 25 , 26 ]. Furthermore, 131 I-avid malignancies beyond DTC have been identified by 131 I WBS with or without SPCET/CT, such as primary lung cancer, gastric adenocarcinoma, metastatic salivary gland tumor, and papillary meningioma [ 27 ].…”

Papillary Thyroid Carcinoma With Breast and Bone Metastasis

“…Among organs prone to distant metastases, the lungs are the most common (53.4%), followed by bone (28.1%), liver (8.3%), and brain (4.7%) 8,13,14 ; metastases in other organs, such as breasts, skin, eyes, pancreas, and skeletal muscle, are rare. [15][16][17][18][19] Distant metastases significantly increase mortality from PTC, and the median survival time of patients with multi-organ distant metastasis (MODM) is significantly lower than that of patients with single-organ distant metastasis (SODM), i.e., 6 months vs 29 months, respectively. The 5-year survival rate of MODM is also significantly lower than that of SODM, at 15.3% vs 77.6%, respectively.…”