Solitary breast cancer metastasis to the bladder: An unusual occurrence

Zagha, Ralph M.; Hamawy, Karim

doi:10.1016/j.urolonc.2006.05.013

Cited by 25 publications

(27 citation statements)

References 15 publications

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“…Obtaining a proper clinical history and the use of immunohistochemistry, e.g. antibodies to oestrogen and progesterone receptors, uroplakin and thrombomodulin [19], will help to reach a correct diagnosis (Table 1).…”

Section: Bladdermentioning

confidence: 99%

Secondary neoplasms of the urinary system and male genital organs

et al. 2009

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BACKGROUND AND AIMS In this review we discuss those secondary tumours involving the urinary system and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlight morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin. materials AND METHODS Based on MEDLINE database searches all reports of secondary tumours involving the urinary system (kidney and bladder) and male genital organs (prostate, testis and penis) were examined. RESULTS and discussion Involvement by a secondary tumour occurs either as a metastasis or by direct extension. Among non‐genitourinary primary sites, colorectal, pulmonary, skin (melanoma) and breast are the most common contributors. Secondary spread from a genitourinary site primary tumour to another genitourinary organ occurs most frequently between the prostate and urinary bladder, given the intimate topographic proximity of the two. The prognosis is very poor, as the secondary tumour usually occurs in patients with carcinoma in the late stages. Few secondary tumours have distinctive histological and immunohistochemical features, making it difficult to make the appropriate diagnosis. Hence, knowledge of the history and clinical setting are particularly important in these cases. CONCLUSION The urinary system and male genital organs are not common sites for secondary tumours. They often go either undiagnosed or misdiagnosed in the clinical follow‐up of patients with cancer. Accurate diagnosis is essential because of differing therapeutic approaches compared with a primary neoplasm.

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Section: Bladdermentioning

confidence: 99%

Secondary neoplasms of the urinary system and male genital organs

et al. 2009

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“…In the advent of an unknown cancer history or inconclusive malignant history, we propose to take a biopsy and to look for the presence of estrogen receptors as this offers an opportunity for a well-tolerated treatment that can produce long-term disease control and allows a conservative approach with regard to the local treatment. Zagha et al promoted a more invasive approach [4]. After discovering bladder metastasis of a primary breast cancer, they performed a partial cystectomy, followed by long-term treatment with fulvestrant.…”

Section: Discussionmentioning

confidence: 99%

Tamoxifen to treat urge-incontinence from an isolated bladder metastasis of a primary breast cancer

Reichman¹,

Michielsen²,

Grève³

2012

cejurol1/2012

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ObjectivesManaging urge-incontinence after metastatic lobular carcinoma of the breast into the bladder.Material and methodsCase report and review of the pertinent English language literature.ResultsConservative management with tamoxifen resulted in clinical and partial radiological remission and the urge-incontinence disappeared.ConclusionA conservative mode of treatment is possible for metastatic lobular carcinoma of the breast into the bladder.

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“…In such cases, the differential diagnosis should also include rare variants of UC, that is, the micropapillary, lymphoepithelioma-like and plasmacytoid variants of UC [59, 60]. Obtaining a proper clinical history and information on the use of immunohistochemistry, for example, antibodies to oestrogen and progesterone receptors, uroplakin and thrombomodulin (see below) [59, 61, 62], will help to arrive at a correct diagnosis. Secondary lobular carcinoma of the breast mimics very closely the rare variant of UC with lobular carcinoma-like features [59].…”

Section: Pathologymentioning

confidence: 99%

“…It is important to recognize this rare variant to avoid a misdiagnosis of metastatic lobular carcinoma of the breast, especially in small biopsies [63]. Moreover, the presence of unusual monomorphic growth patterns without accompanying conventional urothelial carcinoma features, and the appearance of tumour cells invading towards the luminal surface from the outside may be of help [61]. …”

Section: Pathologymentioning

confidence: 99%

“…Some authors reported differences in hormonal (ER, PR) and HER2 expression between primary and metastatic tissues, with discordance rates ranging from 24 to 39% [7, 19, 39, 43, 61, 65-68]. Interestingly, patients whose tumour status changed from positive to negative (positive/negative) have shorter median survivals than positive/positive or negative/negative patients [43, 65, 69].…”

Section: Hormonal Statusmentioning

confidence: 99%

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Bladder Metastases from Breast Cancer: Managing the Unexpected. A Systematic Review

et al. 2017

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Breast cancer (BrC) has the highest incidence among females world over and it is one of the most common causes of death from cancer overall. Its high mortality is mostly due to its propensity to rapidly spread to other organs through lymphatic and blood vessels in spite of proper treatment. Bladder metastases from BrC are rare, with 50 cases having been reported in the last 60 years. This review aims to discuss some critical points regarding this uncommon condition. First, we performed a systematic review of the literature in order to draw a clinical and pathological profile of this entity. On this basis, its features in terms of diagnostic issues, imaging techniques, and survival are critically examined. Most bladder metastases from BrC are secondary lobular carcinoma, which mimic very closely the rare variant of urothelial cancer with lobular carcinoma-like features (uniform cells with an uncohesive single-cell, diffusely invasive growth pattern); thus, immunohistochemistry is mandatory to arrive at a correct diagnosis. This article summarizes the current knowledge regarding the incidence, clinical presentation, diagnosis, prognosis, and treatment of bladder metastases in patients with BrC.

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Solitary breast cancer metastasis to the bladder: An unusual occurrence

Cited by 25 publications

References 15 publications

Secondary neoplasms of the urinary system and male genital organs

Secondary neoplasms of the urinary system and male genital organs

Tamoxifen to treat urge-incontinence from an isolated bladder metastasis of a primary breast cancer

Bladder Metastases from Breast Cancer: Managing the Unexpected. A Systematic Review

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