Solitary angiokeratoma of tongue: A case report and review of the literature

Solitary Angiokeratoma in a Young Man: A Rare Case Report

“…Lastly, solitary or multiple AKs are single or multiple welldefined plaques that are red-black in color and commonly found on the lower limbs. Solitary lesions can be mistaken for melanoma [8][9][10][11]. Although they differ clinically in their appearance, morphology, and anatomical localization, solitary AK lesions and melanoma share similar histological features.…”

“…The only difference between the histological pictures of cutaneous and oral AKs is that hyperparakeratosis is evident in oral lesions, whereas hyperorthokeratosis can be observed in skin lesions [ 15 ]. Increased proliferative activity normally takes place on the surface of vascular malformations that are adjacent to the epidermis or epithelium, and it has been believed to cause this reactive epidermal or oral epithelium development [ 11 ]. On contrary, lymphangioma is formed of dilated lymphatic spaces lined by a single attenuated layer composed of endothelial cells involving the dermis, subcutis, and sometimes the underlying fascia and skeletal muscle.…”

Solitary Angiokeratoma of the Labial Mucosa: Report of a Rare Case and Literature Review

“…Cutaneous and oral AK have similar histological pictures except that hyperparakeratosis is seen in oral lesions, while hyperorthokeratosis is seen in cutaneous lesions [ 1 , 11 ]. It has been suggested that the reactive epidermal or epithelium growth is due to the increased proliferative activity on the surface of vascular malformations that are near to the epidermis or epithelium [ 12 ]. In our case, the absence of mass of fibrous connective tissue excluded the irritation fibroma.…”