Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in Women with Overactive Bladder Syndrome: Results of a Randomized Controlled Crossover Study

Abstract

Aims: This study compared the effectiveness of solifenacin succinate (SS) versus percutaneous tibial nerve stimulation (PTNS) in women with overactive bladder syndrome (OABS). Methods: A randomized controlled crossover study of 40 women with OABS was performed. Patients were randomized into two groups. In group A, patients received SS and then PTNS. In group B, patients underwent PTNS and then SS. Voiding diaries, quality of life surveys and patient perception of intensity of urgency questionnaire were performed before and after each treatment. The global impression of improvement questionnaire was performed at the end of the study. Results: A reduction in the number of daily micturitions, episodes of nocturia and urge incontinence were found with both SS and PTNS in all groups, but PTNS showed a greater effectiveness than SS. There was an increase in voided volume in all groups with both SS and PTNS, but patients treated with PTNS had a greater increase. PTNS showed greater effectiveness in patient perception of urgency and quality of life. Conclusion: This study demonstrates the effectiveness of SS and PTNS In women with overactive bladder symptoms. However, greater improvements were found with PTNS.

Role of percutaneous posterior tibial nerve stimulation either alone or combined with an anticholinergic agent in treating patients with overactive bladder

“…Scaldazza et al [10] have reported results of a better response in patients treated with PTNS than in patients treated with solifenasin. In our study, we aimed to evaluate the efficacy of the combination therapy in contrast to the current literature.…”

“…[8] Some randomized controlled studies compared PTNS and anticholinergic drugs (ACDs). [9,10] This study aimed to investigate efficacy and safety of PTNS alone or together with an anticholinergic agent in patients who were diagnosed with OAB and did not respond sufficiently to previous conservative treatment options.…”

Percutaneous Tibial Nerve Stimulation and Sacral Neuromodulation: an Update

“…A recent randomized control crossover study of solifenacin succinate and PTNS used bladder-specific outcomes. Using these outcome tools, both groups showed statistically significant improvement in micturition parameters including frequency, urge incontinence, and voided volume [14].…”

Clinical optimal dose of solifenacin succinate for�nursing patients after transurethral resection of the prostate during the perioperative period

“…Research has found that SOL is efficacious for women with overactive bladder syndrome based on the results of a randomized controlled crossover study (6). Huo et al (7) suggested that a combination of SOL and naftopidil effectively relieves the symptoms of female overactive bladder and improves the patient's quality of life in a randomized controlled crossover study.…”