Solid Xenon Carrier Based on α-Cyclodextrin: Properties, Preparation, and Application

Prokhorov, Dmitry; Kutyshenko, V. P.; Tarahovsky, Yury S.; Kukushkin, N. I.; Хренов, М. О.; Kovtun, Anatoly L.; Zakharova, N. M.

doi:10.1016/j.xphs.2022.08.014

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…The findings of Rajewski et al [ 39 , 40 ] showed that sulfoalkylether derivatives gave no observable effects in acute toxicity studies and no negative renal histopathology. In its turn, α-CD being also a recognized and validated pharmaceutical excipient [ 41 ] proposed for oral administration [ 42 , 43 ] was taken for the sake of comparison as a representative of CDs composed of 6 α-D-glucopyranose blocks with the less diameter of a hydrophobic cavity among the native CDs. Since the drug/CD association constant cannot provide exhaustive information on the prior factors determining the driving force of the host–guest inclusion phenomenon at a molecular level, in the present study this issue was disclosed via the thermodynamic study of RLZ–SBE-β-CD binding.…”

Section: Introductionmentioning

confidence: 99%

Controlling the Solubility, Release Rate and Permeation of Riluzole with Cyclodextrins

Volkova,

Simonova,

Perlovich

2024

Pharmaceutics

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Riluzole (RLZ), a sodium channel-blocking benzothiazole anticonvulsant BCS class II drug, is very slightly soluble in aqueous medium. To improve aqueous solubility and modulate dissolution rate and membrane permeability, complex formation of RLZ with two cyclodextrin, α-cyclodextrin (α-CD) and sulfobutylether-β-cyclodextrin (SBE-β-CD), was studied. The stability constants demonstrated a greater affinity of SBE-β-CD towards RLZ compared to α-CD. A solubility growth of 1.7-fold and 3.7-fold with α-CD and SBE-β-CD, respectively, was detected in the solutions of 1% cyclodextrins and accompanied by the permeability reduction. For 1% CD solutions, several biopolymers (1% w/v) were tested for the membrane permeability under static conditions. The synergistic positive effect of α-CD and polymer on the solubility accompanied by unchanged permeability was revealed in RLZ/α-CD/PG, RLZ/α-CD/PEG400, and RLZ/α-CD/PEG1000 systems. Solid RLZ/CD complexes were prepared. Dynamic dissolution/permeation experiments for the solid samples disclosed the characteristic features of the release processes and permeation rate through different artificial membranes. The maximal permeation rate was determined across the hydrophilic semi-permeable cellulose membrane followed by the lipophilic PermeaPad barrier (model of intestinal and buccal absorption) and polydimethylsiloxane-polycarbonate membrane (simulating transdermal delivery way). Different mode of the permeation between the membranes was estimated and discussed.

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Section: Introductionmentioning

confidence: 99%

Controlling the Solubility, Release Rate and Permeation of Riluzole with Cyclodextrins

Volkova,

Simonova,

Perlovich

2024

Pharmaceutics

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Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies

Pagliaro,

Weber,

Femminò

et al. 2024

Basic Res Cardiol

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Despite recent progress, ischemic heart disease poses a persistent global challenge, driving significant morbidity and mortality. The pursuit of therapeutic solutions has led to the emergence of strategies such as ischemic preconditioning, postconditioning, and remote conditioning to shield the heart from myocardial ischemia/reperfusion injury (MIRI). These ischemic conditioning approaches, applied before, after, or at a distance from the affected organ, inspire future therapeutic strategies, including pharmacological conditioning. Gasotransmitters, comprising nitric oxide, hydrogen sulfide, sulfur dioxide, and carbon monoxide, play pivotal roles in physiological and pathological processes, exhibiting shared features such as smooth muscle relaxation, antiapoptotic effects, and anti-inflammatory properties. Despite potential risks at high concentrations, physiological levels of gasotransmitters induce vasorelaxation and promote cardioprotective effects. Noble gases, notably argon, helium, and xenon, exhibit organ-protective properties by reducing cell death, minimizing infarct size, and enhancing functional recovery in post-ischemic organs. The protective role of noble gases appears to hinge on their modulation of molecular pathways governing cell survival, leading to both pro- and antiapoptotic effects. Among noble gases, helium and xenon emerge as particularly promising in the field of cardioprotection. This overview synthesizes our current understanding of the roles played by gasotransmitters and noble gases in the context of MIRI and cardioprotection. In addition, we underscore potential future developments involving the utilization of noble gases and gasotransmitter donor molecules in advancing cardioprotective strategies.

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Solid Xenon Carrier Based on α-Cyclodextrin: Properties, Preparation, and Application

Cited by 2 publications

References 16 publications

Controlling the Solubility, Release Rate and Permeation of Riluzole with Cyclodextrins

Controlling the Solubility, Release Rate and Permeation of Riluzole with Cyclodextrins

Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies

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