Solid-supported synthesis of oligomeric bioconjugates

DNA-Multichromophore Systems

“…236 Modified nucleoside analogs, some containing deoxyribose and some not, are typically chemically synthesized and derivatized to the 5′-DMT-protected, 3′-phosphoramidite intermediate for automated DNA synthesis of oligonucleotides. Oligonucleotide synthesis with phosphoramidite coupling has been extensively studied and proceeds with high-yielding steps, 100, 237 which allows a wide range of lengths to be accessible.…”

A Convenient Solid-Phase Method for the Synthesis of Novel Oligonucleotide-Folate Conjugates

“…the one which can be used for the attachment of a variety of pendant groups like fluorescent dyes, biotin or other molecules, that is, peptides, to oligonucleotides via solid-phase synthesis. [3,4] Here, we wish to Oligonucleotide-Folate Conjugates report the modification and extension of the method [4] toward solid-phase synthesis of oligonucleotide conjugates with folic acid.…”

Versatile Synthesis of MRI Contrast Agents Based on Carbon-Substituted Triazacycloalkanes

“…This can be performed in solution by allowing functional groups of bioactive molecules to react with activated bifunctional label molecules [8,9]. Synthetic biopolymers, such as oligonucleotides and oligopeptides, can be labeled also on solid phase using appropriately derivatized labels as monomers during chain assembly [10].…”