Solid-supported Synthesis of 3, 4-dihydrobenzo [2, 3-d] pyrimidines

Abstract

Different 3,4-dihydrobenzo[2,3-d] pyrimidine derivatives were synthesized by the condensation of substituted 1, 3- cyclohexadienes and formamide, using inorganic solid supports under microwaves. Simple and commonly available compounds were used as starting materials in the reactions. The compounds were tested against different fungal and bacterial strains and found considerably effective. Key words: inorganic solid supports; microwave; benzopyrimidines; environmentally benign; antimicrobial DOI: 10.3126/njst.v11i0.4138Nepal Journal of Science and Technology 11 (2010) 153-158

Review of Microwave-Assisted Synthesis of Benzo-Fused Six-MemberedN,N-Heterocycles

“…These observations demonstrate that this method is an expeditious, facile and environmentally benign one for organic synthesis. [62] Arya et al [63] 15) by combining 2-3 steps as a one pot reaction reduced the pollution at source as important green chemical theme. [64] The required spiro[indole-thiazolidines] were prepared by the multi-component condensation between indole-2,3-dione, amines and marcaptoacetic acid [65][66] using montmorillonite KSF as solid support.…”