Solid subtype predicts early bone metastases in sensitive EGFR-mutated lung adenocarcinoma patients after surgery

Xiong, Anning; Li, Changhui; Xu, Jianlin; Yang, Xiaohua; Nie, Wei; Chu, Tianqing; Zhang, Wei; Zhong, Runbo; Pan, Feng; Shen, Yao; Lou, Yu‐Qing; Zhang, Bo; Han, Baohui; Zhang, Xueyan

doi:10.1016/j.lungcan.2021.02.029

Cited by 2 publications

(1 citation statement)

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“…In early-stage lung adenocarcinoma, the number of circulating endothelial progenitor cells differed according to histological subtype and was reported to be the highest in the solid type [ 19 ]. Two reports investigating patients who underwent resection for EGFR-mutated lung cancer showed that the incidence of brain metastasis was higher and the time for development of brain metastasis was shorter in patients with micropapillary patterns [ 20 ], whereas patients with solid patterns had a higher incidence of bone metastasis and a shorter time of development of bone metastasis [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Combination of epidermal growth factor receptor mutation and the presence of high-grade patterns is associated with recurrence in resected stage I lung adenocarcinoma

Kondo

Ichinose

Ninomiya

et al. 2022

Interactive CardioVascular and Thoracic Surgery

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OBJECTIVES This study aimed to evaluate the prognostic impact of the combination of epidermal growth factor receptor (EGFR) mutation and the presence of high-grade patterns (solid or micropapillary component) in resected stage I lung adenocarcinoma. METHODS Patients who underwent curative resection for pathological stage I lung adenocarcinoma and EGFR mutation analysis were included in this study. The impact of the combination of EGFR mutation and the presence of >5% high-grade patterns on recurrence-free survival (RFS) was retrospectively analysed using Cox proportional hazards model and propensity score-matched analysis. RESULTS Among the included 721 patients, EGFR mutations were positive in 380 (52.7%). In the EGFR-mutated group, cases with high-grade patterns showed poorer RFS than those without (5-year RFS, 77.7% vs 92.5%, P < 0.001), whereas there were no significant prognostic differences in the EGFR wild-type group (5-year RFS, 89.8% vs 88.2%, P = 0.807). Multivariable analyses revealed that the combination of EGFR mutations and the presence of high-grade patterns was associated with poor RFS (hazard ratio = 1.655, P = 0.035). Furthermore, EGFR mutation was associated with poor RFS in the group with high-grade patterns (hazard ratio = 2.108, P = 0.008). After propensity score matching, EGFR-mutated cases with high-grade patterns showed poorer RFS (P = 0.028). CONCLUSIONS The combination of EGFR mutation and the presence of high-grade patterns was associated with recurrence in resected stage I lung adenocarcinoma. Histological subtypes, including minor components, should be considered when evaluating the risk of recurrence in patients with EGFR-mutated lung adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%