Solid-state to solution helicity inversion of pseudotetrahedral chiral copper(ii) complexes with 2,4-dihalo-salicylaldiminate ligands

Abstract

Steric constraints by the halogen substituents show an efficient control of stereochemical behaviours of the complexes.

Pseudotetrahedral Zn(ii)-(R or S)-dihalogen-salicylaldiminato complexes with Λ- or Δ-chirality induction at-metal

“…[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] The use of asymmetric bidentate ligands with a chiral centre (R-or S-A^B) provides two diastereomers Δ-M(R-A^B) 2 and Λ-M (R-A^B) 2 {or Λ-M(S-A^B) 2 and Δ-M(S-A^B) 2 } with one being thermodynamically preferred. [29][30][31][32][33][34][35][36][37][38] In fact, the thermo-dynamics of intra-and intermolecular interactions controls Δ vs. Λ-chirality induction at-metal in R-or S-ligated complexes. [29][30][31][32][34][35][36][37][38] Therefore, experimental results in the solid and solution along with theoretical calculations reveal that the chirality induction at-metal can be phase dependent if the intramolecular interactions for Δ/Λ are very close in energy since the intermolecular interactions differ.…”

“…[29][30][31][32][33][34][35][36][37][38] In fact, the thermo-dynamics of intra-and intermolecular interactions controls Δ vs. Λ-chirality induction at-metal in R-or S-ligated complexes. [29][30][31][32][34][35][36][37][38] Therefore, experimental results in the solid and solution along with theoretical calculations reveal that the chirality induction at-metal can be phase dependent if the intramolecular interactions for Δ/Λ are very close in energy since the intermolecular interactions differ. Thus, a solvationinduced chirality inversion from Λ-CuR or Δ-CuS in the solidstate to Δ-CuR or Λ-CuS in solution (or gas phase structure calculations) was reported.…”

A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents

“…In this case, the oxygen and nitrogen atoms on the sulfisoxazole ring, the oxygen atom of sulfonyl groups and oxygen and nitrogen atoms attached to the benzene ring are thought to be involved in the hydrogen bonds' formation. Ismail et al (2021) [49] studied several complexes in which the N 1 ,N 2 -bis(furan-2-ylmethylene)-4-methylbenzene-1,2-diamine (L) is complexed with several metals, namely Ag(I), Cr(III), Fe(III), Co(II), Cu(II) and Cd(II) (13)(14)(15)(16)(17)(18), and studied their cytotoxicity against the HepG2 cell lines. The IC 50 values were 12.9 µg/mL, 14.8 µg/mL, 7.31 µg/mL, 8.53 µg/mL, 17.1 µg/mL and 1.95 µg/mL, respectively.…”

“…The 30 complex reduced the cell viability, in all types, by more than 80%. The IC 50 values were 13 The mechanism underlying the antiproliferative activities was suggested to proceed through the induction of the caspase 3-dependent apoptosis in vitro. Additionally, the cellular target of compound 34 was predicted by molecular docking studies, suggesting that it possesses a high affinity to specifically bind the BIR3 domain of XIAP.…”

“…Complexes containing the transition metals platinum, gold and silver have attracted much attention due to their antitumor effects. Schiff bases, as well as diarylureas [8][9][10], have been defined as "privileged" ligands in organic synthesis, thanks to their affordability, easy synthesis and different biological activities and ability to form complexes with almost all metals [11][12][13]. Actually, they may form complexes with transition metals, platinum group metals (PGM) [14], lanthanides [15,16], and actinides [17,18] and many of them have been extensively described in the literature [19,20].…”