Solid‐State <sup>1</sup>H NMR Studies of Degradable Poly(ethylene oxide) Based Hydrogels

Naraghi, Kaynoush; Meurer, B.; Lutz, P.

doi:10.1002/marc.200400605

Cited by 12 publications

(7 citation statements)

References 19 publications

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“…Considering the ability of PDXL chains or PEO-block-PDXL-block-PEO copolymers [45] to undergo facile hydrolysis under acidic conditions, and the good swelling properties of PDXL based networks, applications in controlled release experiments can be foreseen.…”

Section: Resultsmentioning

confidence: 99%

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Design and Properties of Degradable Networks Based on Free Radical Copolymerization of Poly(1,3‐dioxolane) Macromonomers with Hydrophobic or Hydrophilic Comonomers in Water

Sahli

Belbachir

Lutz

2005

Macro Chemistry & Physics

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Summary: Potentially degradable amphiphilic or hydrophilic copolymeric networks were synthesized directly in water by free radical copolymerization of α, ω‐poly(1,3‐dioxolane) (PDXL) macromonomers with vinyl monomers such as methyl methacrylate, butyl methacrylate, styrene or 2‐hydroxyethyl methacrylate. Since PDXL macromonomers behave typically as amphiphiles, the rates of copolymerizations with hydrophobic comonomers are much higher than those of similar reactions carried out in organic solvents. Therefore crosslinking in water takes place rapidly. Once swollen to equilibrium in appropriate solvents, the physicochemical properties of the amphiphilic (or hydrophilic) copolymeric PDXL networks were investigated. The volume degree of equilibrium swelling and uniaxial compression modulus strongly depended upon the macromonomer molar mass (and concentration), and also the hydrophobic/hydrophilic balance. Their solid state properties were examined by DSC and compared to those of homopolymeric PDXL networks.Amphiphilic PDXL conetworks synthesized directly in water by free radical copolymerization of bifunctional PDXL macromonomers with hydrophobic comonomers such as styrene or butyl methacrylate.magnified imageAmphiphilic PDXL conetworks synthesized directly in water by free radical copolymerization of bifunctional PDXL macromonomers with hydrophobic comonomers such as styrene or butyl methacrylate.

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Section: Resultsmentioning

confidence: 99%

“…PDXL networks or conetworks are constituted of PDXL chains sensitive to acidic media, i.e., PDXL chains, or PDXL networks degrade. [21,45] Provided poly(HEMA) could be introduced into such PXDL networks, the resulting conetworks would swell to a higher extent in water and be degradable.…”

Section: Characterization Of Swollen Pdxl-co-s or Co-bma Networkmentioning

confidence: 99%

Design and Properties of Degradable Networks Based on Free Radical Copolymerization of Poly(1,3‐dioxolane) Macromonomers with Hydrophobic or Hydrophilic Comonomers in Water

Sahli

Belbachir

Lutz

2005

Macro Chemistry & Physics

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“…Degradation of POE‐PDXL‐POE (POE, polyoxyethylene) hydrogels in water or CH 2 Cl 2 has been studied in the presence of triflic acid (pH ~ 3 in water and pH ~ 6 in CH 2 Cl 2 ) 25 . It was concluded that degradation of PDXL chains proceeds by depropagation starting from primary scission taking place anywhere in the chain, as shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

Degradation of poly(1,3‐dioxolane). Depolymerization versus hydrolysis

Kubisa

2023

Polymer International

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There is renewed interest in polymers of 1,3‐dioxolane (DXL), especially as components of degradable polymer networks. DXL, a five‐membered cyclic acetal, is easily available on a commercial scale. Due to the relatively low strain of the five‐membered ring, its polymerization proceeding by a cationic mechanism is reversible. Above the ceiling temperature in the presence of an acid catalyst, it therefore undergoes depolymerization and this is one of the possible ways of degradation. On the other hand, monomeric units within the poly(1,3‐dioxolane) (PDXL) chain are connected by acetal bonds that are susceptible to acid‐catalyzed hydrolysis and this offers an alternative route for PDXL chain degradation. Polymer networks with connecting PDXL blocks are designed as commodity plastic materials but also as gels intended for biomedical applications. In both applications the possibility of gel disintegration by controlled degradation of connecting PDXL blocks is advantageous. The degradation in the two instances should proceed under different conditions, however. Degradation of commodity plastic material may proceed at higher temperatures in ‘dry’ conditions while biomaterials should degrade at mild physiological temperatures in an aqueous environment. In published papers, the distinction between the two routes of degradation is not always considered. In the present mini‐review, both mechanisms of degradation are presented and the available information on PDXL bloc degradation is critically evaluated. © 2023 Society of Industrial Chemistry.

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“…However, the potential of these conetworks is not fully developed, since they usually contain at least one broadly distributed phase, either from the macromer/monomer approach, − by free radical cross-linking of telechelic block copolymers , or random cross-linking of linear homopolymers − and star-shaped homopolymers or dendrimers . Only a few examples of APCNs with only narrowly distributed segments, so-called “near perfect” or “ideal” APCNs are known, being PEG/PDMS, , the APCNs of Patrickios, who cross-links acrylate-based multiblock copolymers by group transfer polymerization ,− and star-shaped PIB and PEG based APCNs of Erdodi and Iván with perfect chain end coupling, or by a combination of both strategies .…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic Polymer Conetworks Based on End Group Cross-Linked Poly(2-oxazoline) Homo- and Triblock Copolymers

et al. 2013

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Novel amphiphilic polymer conetworks (APCNs) were prepared via end group cross-linking. To this end, poly(2-methyloxazoline) (PMOx), poly(2-butyloxazoline) (PBuOx), and the triblock copolymers PMOx-b-PBuOx-b-PMOx were synthesized by cationic ring-opening polymerization in varying block lengths and telechelically modified with N,N -bis(2-aminoethyl)ethylendiamine (TREN). First the cross-linking with 1,4-dibromo-2-butene (DBB) was established for the homopolymers. The swelling of those matches the theoretical value for full cross-linking, indicating that in this way “near perfect” networks could be obtained. Mixtures of the homopolymers and the triblock copolymers were cross-linked with DBB to give APCNs with similar polymer segments but different network topology. AFM showed that all formed APCNs are nanophase separated with slight structural differences in the nanostructures when comparing conetworks with similar composition but different cross-linking strategies. The more drastic difference between APCNs of different topologies was found in their swelling characteristics, which clearly proves the influence of conetwork structure on their properties.

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Solid‐State ¹H NMR Studies of Degradable Poly(ethylene oxide) Based Hydrogels

Cited by 12 publications

References 19 publications

Design and Properties of Degradable Networks Based on Free Radical Copolymerization of Poly(1,3‐dioxolane) Macromonomers with Hydrophobic or Hydrophilic Comonomers in Water

Design and Properties of Degradable Networks Based on Free Radical Copolymerization of Poly(1,3‐dioxolane) Macromonomers with Hydrophobic or Hydrophilic Comonomers in Water

Degradation of poly(1,3‐dioxolane). Depolymerization versus hydrolysis

Amphiphilic Polymer Conetworks Based on End Group Cross-Linked Poly(2-oxazoline) Homo- and Triblock Copolymers

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Solid‐State 1H NMR Studies of Degradable Poly(ethylene oxide) Based Hydrogels

Cited by 12 publications

References 19 publications

Design and Properties of Degradable Networks Based on Free Radical Copolymerization of Poly(1,3‐dioxolane) Macromonomers with Hydrophobic or Hydrophilic Comonomers in Water

Design and Properties of Degradable Networks Based on Free Radical Copolymerization of Poly(1,3‐dioxolane) Macromonomers with Hydrophobic or Hydrophilic Comonomers in Water

Degradation of poly(1,3‐dioxolane). Depolymerization versus hydrolysis

Amphiphilic Polymer Conetworks Based on End Group Cross-Linked Poly(2-oxazoline) Homo- and Triblock Copolymers

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Solid‐State ¹H NMR Studies of Degradable Poly(ethylene oxide) Based Hydrogels