Solid-State nanopore DNA Sequencing: Advances, challenges and prospects

He, Shixuan; Liu, Yexiang; Fang, Shaoxi; Li, Yadong; Weng, Ting; Tian, Rong; Yin, Yajie; Zhou, Daming; Yin, Bohua; Wang, Yunjiao; Liang, Liyuan; Xie, Wanyi; Wang, Deqiang

doi:10.1016/j.ccr.2024.215816

Coordination Chemistry Reviews

2024

DOI: 10.1016/j.ccr.2024.215816

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Solid-State nanopore DNA Sequencing: Advances, challenges and prospects

Shixuan He,

Yexiang Liu,

Shaoxi Fang

et al.

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Research Progress on Saccharide Molecule Detection Based on Nanopores

Yin,

Xie,

Fang

et al. 2024

Sensors

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Saccharides, being one of the fundamental molecules of life, play essential roles in the physiological and pathological functions of cells. However, their intricate structures pose challenges for detection. Nanopore technology, with its high sensitivity and capability for single-molecule-level analysis, has revolutionized the identification and structural analysis of saccharide molecules. This review focuses on recent advancements in nanopore technology for carbohydrate detection, presenting an array of methods that leverage the molecular complexity of saccharides. Biological nanopore techniques utilize specific protein binding or pore modifications to trigger typical resistive pulses, enabling the high-sensitivity detection of monosaccharides and oligosaccharides. In solid-state nanopore sensing, boronic acid modification and pH gating mechanisms are employed for the specific recognition and quantitative analysis of polysaccharides. The integration of artificial intelligence algorithms can further enhance the accuracy and reliability of analyses. Serving as a crucial tool in carbohydrate detection, we foresee significant potential in the application of nanopore technology for the detection of carbohydrate molecules in disease diagnosis, drug screening, and biosensing, fostering innovative progress in related research domains.

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Research Progress on Saccharide Molecule Detection Based on Nanopores

Yin,

Xie,

Fang

et al. 2024

Sensors

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show abstract

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Solid-State nanopore DNA Sequencing: Advances, challenges and prospects

Cited by 1 publication

References 208 publications

Research Progress on Saccharide Molecule Detection Based on Nanopores

Research Progress on Saccharide Molecule Detection Based on Nanopores

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