Solid-State Nanopore

Yuan, Zhishan; Wang, Chengyong; Xin, Yi; Zhang, Ni; Chen, Yunfei; Li, Tie

doi:10.1186/s11671-018-2463-z

Cited by 48 publications

(35 citation statements)

References 73 publications

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“…Third, according to present fabrication methods, it is difficult to fabricate a two-nanopore system and optical trap nanopore system with high accuracy and Si probe No need for nanopores addressing Adjacent DNA affects accuracy~0.1 [32] reproducibility, which is very significant for nanopore DNA detection. A helium ion beam may be the key technology to solve this problem [11,58]. Thus, we expect that DNA nanopore sequencing will continue to be a research focus and can be integrated with more new ideas and innovative approaches to realize low error rates, rapid and high parallel recording, and long read lengths of up to 100 kilobases.…”

Section: Resultsmentioning

confidence: 99%

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Controlling DNA Translocation Through Solid-state Nanopores

et al. 2020

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Compared with the status of bio-nanopores, there are still several challenges that need to be overcome before solid-state nanopores can be applied in commercial DNA sequencing. Low spatial and low temporal resolution are the two major challenges. Owing to restrictions on nanopore length and the solid-state nanopores' surface properties, there is still room for improving the spatial resolution. Meanwhile, DNA translocation is too fast under an electrical force, which results in the acquisition of few valid data points. The temporal resolution of solid-state nanopores could thus be enhanced if the DNA translocation speed is well controlled. In this mini-review, we briefly summarize the methods of improving spatial resolution and concentrate on controllable methods to promote the resolution of nanopore detection. In addition, we provide a perspective on the development of DNA sequencing by nanopores.

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Section: Resultsmentioning

confidence: 99%

“…Significant progress has been made in DNA sequencing by nanopores, such as solid-state nanopores [2,11] and protein nanopores [2,7]. DNA sequencing by protein nanopores has been achieved [7].…”

Section: Introductionmentioning

confidence: 99%

Controlling DNA Translocation Through Solid-state Nanopores

et al. 2020

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“…This method allows precise control of the pore size, low cost of fabrication and ideal conditions for automation. [7][8][9][10] In the electrochemical etching process, a solid-state material is placed between an etching agent and a stopping solution. 11 Once the pore is formed, chemical braking takes place thus concluding the process.…”

Section: Introductionmentioning

confidence: 99%

Hybrid microchannel-solid state micropore device for fast and optical cell detection

et al. 2020

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“…As a fundamental issue, the fabrication of solid-state nanopores inspired extensive studies. Extensive reviews on the fabrication of nanopores have been published by various groups [39,40,41]. Although technologies, such as focused ion beam (FIB) and focused electron beam (FEB) drilling, are widely used, they can only fabricate nanopores one by one on thin membranes with thicknesses < 100 nm.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Applications of Solid-State Nanopores

Chen

Liu

2019

Sensors

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Nanopores fabricated from synthetic materials (solid-state nanopores), platforms for characterizing biological molecules, have been widely studied among researchers. Compared with biological nanopores, solid-state nanopores are mechanically robust and durable with a tunable pore size and geometry. Solid-state nanopores with sizes as small as 1.3 nm have been fabricated in various films using engraving techniques, such as focused ion beam (FIB) and focused electron beam (FEB) drilling methods. With the demand of massively parallel sensing, many scalable fabrication strategies have been proposed. In this review, typical fabrication technologies for solid-state nanopores reported to date are summarized, with the advantages and limitations of each technology discussed in detail. Advanced shrinking strategies to prepare nanopores with desired shapes and sizes down to sub-1 nm are concluded. Finally, applications of solid-state nanopores in DNA sequencing, single molecule detection, ion-selective transport, and nanopatterning are outlined.

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Solid-State Nanopore

Cited by 48 publications

References 73 publications

Controlling DNA Translocation Through Solid-state Nanopores

Controlling DNA Translocation Through Solid-state Nanopores

Hybrid microchannel-solid state micropore device for fast and optical cell detection

Fabrication and Applications of Solid-State Nanopores

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