Solid-State Mechanochemical Clemmensen Reduction

Abstract

Mechanochemical synthesis has emerged as a sustainable alternative to traditional organic reactions, offering several advantages, including reduced solvent usage, lower reaction time, lower energy consumption, and enhanced reaction efficiency. In this study, we explored the application of mechanochemistry to Clemmensen reduction, a classic method for converting aldehydes and ketones into alkanes. By employing ball milling as a mechanical activation, we demonstrate the feasibility and efficacy of mechanochemical Clemmensen reduction in various substrates. Our results indicate that this approach offers comparable or improved yields and functional group compatibility compared to conventional methods while minimizing environmental impact. The reaction optimization strategies and scope of substrates are discussed, highlighting the potential of mechanochemical synthesis for sustainable organic transformations.