Solid-state Decomposition of Alkoxyfuroic Acids

Effect of Moisture on Solid Dosage forms. can the Arrhenius Equation be used as a Predictor?

“…More realistic storage, as shall be dealt with below, involves exposure to oxygen and moisture. (Carstensen and Kothari, 1981) In Bawn kinetics, the decomposition of the parent compound occurs both in the solid state and in solution (in the decomposition liquid), and the first part of these curves adheres to an equation of the type:…”

Solid-Solid Reaction Between Sulfacetamide and Phthalic Anhydride

“…Although thermal decomposition is an important consideration in the processing, testing, and storage of solid dosage forms, only a limited number of reports in the pharmaceutical literature have been concerned with the physicochemical mechanism and kinetics of solid-state reactions (5)(6)(7)(8)(9)(10)(11)(12)(13). In general, the chemistry of solids has been presented in several texts (14-18).…”

Interactions in the Solid State II: Interaction of Sodium Bicarbonate with Substituted Benzoic Acids in the Presence of Moisture

“…The pressure of the carbon dioxide released from the reaction system was measured using a modified high-vacuum rack similar to that designed and used by Carstensen and MusaF6 Cmtensen and Pothisiri,27.28 and Carstensen and Kothari. 29 The glass components were fused to the system using a propane-oxygen torch. The system incorporated two vacuum pumps, a forepump connected to the diffusion pump, and a pump on the McLeod gauge.…”