Solid State and Thermal Behavior of 17&amp;beta;-Estradiol in Ammonioethyl Methacrylate Ester Copolymer

Wiranidchapong, Chutima

doi:10.5772/28446

Sex Hormones 2012

DOI: 10.5772/28446

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Solid State and Thermal Behavior of 17β-Estradiol in Ammonioethyl Methacrylate Ester Copolymer

Chutima Wiranidchapong¹

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Cited by 2 publications

References 45 publications

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Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression

Wiranidchapong

Ruangpayungsak

Suwattanasuk

et al. 2014

Drug Development and Industrial Pharmacy

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The objectives of this study were to investigate the effect of storage temperature on drug release from matrices containing 10, 40 and 70% w/w ibuprofen in Kollidon® SR (KSR). The matrix tablets were produced by direct compression and then kept at 30 and 45 °C for 3 months. Drug release from the matrix tablets was examined after storage for 0, 1, 4 and 12 weeks. Scanning electron microscope was used to reveal physical appearance of the tablet surface at the respective time intervals. In addition, differential scanning calorimeter was used to investigate glass transition temperature (Tg) of ibuprofen in KSR at 0-100% w/w based on the principle of Gordon-Taylor equation. At 45 °C, the dissolution of ibuprofen in KSR as well as the coalescence of polymer particles were observed to be higher than those of storage at 30 °C. The physical state of ibuprofen dispersed in the polymeric matrix and degree of polymer coalescence led to the variation of drug release. The coalescence of polymer particles was a result of the polymer transition from glassy to rubbery state according to water absorption of KSR and plasticizing effect of ibuprofen. The reduction of the Tg of ibuprofen blended with KSR could be better described by the Kwei equation, a modified version of Gordon-Taylor equation.

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Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression

Wiranidchapong

Ruangpayungsak

Suwattanasuk

et al. 2014

Drug Development and Industrial Pharmacy

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show abstract

Thermal, mechanical and drug release characteristics of an acrylic film using active pharmaceutical ingredient as non-traditional plasticizer

Wiranidchapong

Kieongarm

Managit

et al. 2015

Drug Development and Industrial Pharmacy

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The objective of this study was to investigate thermal and mechanical properties as well as in vitro drug release of Eudragit® RL (ERL) film using chlorpheniramine maleate (CPM) as either active pharmaceutical ingredient or non-traditional plasticizer. Differential scanning calorimeter was used to measure the glass transition temperature (Tg) of 0-100% w/w CPM in ERL physical mixture. Instron testing machine was used to investigate Young's modulus, tensile stress and tensile strain (%) of ERL film containing 20-60% w/w CPM. Finally, a Franz diffusion cell was used to study drug release from ERL films obtained from four formulations, i.e. CRHP0/0, CRHP0/5, CRHP2/0 and CRHP2/5. The Tg of ERL was decreased when the weight percentage of CPM increased. The reduction of the Tg could be described by Kwei equation, indicating the interaction between CPM and ERL. Modulus and tensile stress decreased whereas tensile strain (%) increased when weight percentage of CPM increased. The change of mechanical properties was associated with the reduction of the Tg when weight percentage of CPM increased. ERL films obtained from four formulations could release the drug in no less than 10 h. Cumulative amount of drug release per unit area of ERL film containing only CPM (CRHP0/0) was lower than those obtained from the formulations containing traditional plasticizer (CRHP0/5), surfactant (CRHP2/0) or both of them (CRHP2/5). The increase of drug release was a result of the increase of drug permeability through ERL film and drug solubility based on traditional plasticizer and surfactant, respectively.

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Solid State and Thermal Behavior of 17β-Estradiol in Ammonioethyl Methacrylate Ester Copolymer

Cited by 2 publications

References 45 publications

Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression

Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression

Thermal, mechanical and drug release characteristics of an acrylic film using active pharmaceutical ingredient as non-traditional plasticizer

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