Solid state and solution studies of a vanadium(III)-l-cysteine compound and demonstration of its antimetastatic, antioxidant and inhibition of neutral endopeptidase activities

Synthesis, ab initio calculations, thermal, thermodynamic and antioxidant properties of some oxovanadium(IV) complexes containing N2O2 set of donor atoms

“…The results show that the formation constants were solvent dependent and the trend 5 8.09 ± 0.09 -46.14 ± 0.09 HL 6 8.23 ± 0.32 -46.93 ± 0.32 0.227 HL 7 8.22 ± 0.10 -46.88 ± 0.19 HL 8 8.39 ± 0.23 -47.85 ± 0.37 0.232 HL 9 7.02 ± 0.15 -40.03 ± 0.44 HL 10 7.60 ± 0.49 -43.34 ± 0.19 0.660 HL 11 6.68 ± 0.10 -38.09 ± 0.12 HL 13 8.46 ± 0.41 -48. 25 [33].…”

“…The most common ones being vanadate(V) and vanadyl(IV). Oxovanadium(IV) and (V) have particularly rich coordination chemistry [1,2] that have received much attention, for their use in oxidation and oxo-transfer catalysis, and for their potential therapeutic applications such as the treatment of diabetes [3][4][5][6] and as anticancer agents [7,8].…”

Preface: Recent Advances and Highlights of the 5th International Vanadium Symposium

“…Globally the stability of the vanadium complexes with amino acids follow the order V(V) < V(IV) < V(III) (211). The molecular structure of Na[V IU (Lcys) 2 ] is known since 1993 (212), and interesting in vitro cytotoxic effects towards tumor cells were reported for a distinct V(III)-cysteine compound (213) as well as upon using V(III)-cysteine solutions (211). The preparation of several V(III) complexes containing dipeptides and o-phenanthroline in the coordination sphere have also been reported (192).…”

Potentiometric studies on the formation equilibria of ternary complexes of vanadium(III) with cysteine and some amino acids

“…The insulinomimetic activity of the vanadium(III) maltolato system was first reported in [2]. The investigation of application of vanadium(III) complexes in medicine is growing; some antitumoral activity has been reported, and Papaioannou et al [3] demonstrated the activity of the vanadium(III)-cysteine complexes as antimetastatic, antioxidant, and the inhibition of neutral endopeptidase activities. [3] The effect on actin in hepatoma Morris 5123 cell lines of the vanadium(III)-cysteine complexes was observed.…”

“…The investigation of application of vanadium(III) complexes in medicine is growing; some antitumoral activity has been reported, and Papaioannou et al [3] demonstrated the activity of the vanadium(III)-cysteine complexes as antimetastatic, antioxidant, and the inhibition of neutral endopeptidase activities. [3] The effect on actin in hepatoma Morris 5123 cell lines of the vanadium(III)-cysteine complexes was observed. [4] In vivo coordination structural changes of a potent insulinomimetic agent, bis(picolinato)oxovanadium(IV), were studied by electron spin-echo envelope modulation spectroscopy, [5] and these authors observed that the original binary complex is transformed to a ternary complex with a composition VO(pic)(X), where X represents an amino acid, and suggested that the activity changed substantially by the formation of this ternary complex.…”