Solid-state and mechanical properties of aqueous chitosan-amylose starch films plasticized with polyols

Cervera, Mirna Fernández; Heinämäki, Jyrki; Krogars, Karin; Jørgensen, Anna Cecilia; Karjalainen, Milja; Colarte, Antonio Iraizoz; Yliruusi, Jouko

doi:10.1007/bf02830583

Cited by 30 publications

(41 citation statements)

References 24 publications

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“…This leads to a higher crystallinity that reduces the absorption of water molecules and produces an increase in TS [69]. In general, the crystallinity of films is directly related with increased intermolecular forces, thus increasing the rigidity and brittleness of the film [70].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

The Use of Electric Fields for Edible Coatings and Films Development and Production: A Review

et al. 2010

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Edible films and coatings can provide additional protection for food, while being a fully biodegradable, environmentally friendly packaging system. A diversity of raw materials used to produce edible coatings and films are extracted from marine and agricultural sources, including animals and plants. Electric fields processing holds advantage in producing safe, wholesome and nutritious food. Recently, the presence of a moderate electric field during the preparation of edible coatings and films was shown to influence their main properties, demonstrating its usefulness to tailor edible films and coatings for specific applications. This manuscript reviews the main aspects of the use of electric fields in the production of edible films and coatings, including the effect in their transport and mechanical properties, solubility and microstructure.

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Section: Mechanical Propertiesmentioning

confidence: 99%

The Use of Electric Fields for Edible Coatings and Films Development and Production: A Review

et al. 2010

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“…Chitin and its derivatives may be used as wound or burn dressing components isolated6, 11, 14–20 or associated with other compounds such as polyvinylpirrolidone,21 glycosaminoglycans,15 amylose corn starch,22 dextran sulfate,15 collagen,23 fibroin,24 gelatin,17, 25, 26 hyaluronic acid,25 alginate,9 and cellulose,27 among others. In some cases, plasticizers are used to improve wound or burn dressing functional properties such as flexibility and elasticity.…”

Section: Introductionmentioning

confidence: 99%

“…In some cases, plasticizers are used to improve wound or burn dressing functional properties such as flexibility and elasticity. The most common used plasticizer is glycerol,17, 22 but sorbitol,22 erythritol,22 lactic acid,10 and polyethyleneglycol8 can also be used.…”

Section: Introductionmentioning

confidence: 99%

Effects of chitosan solution concentration and incorporation of chitin and glycerol on dense chitosan membrane properties

et al. 2006

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The aim of this work was to perform a systematic study about the effects induced by chitosan solution concentration and by chitin or glycerol incorporation on dense chitosan membranes with potential use as burn dressings. The membrane properties analyzed were total raw material cost, thickness, morphology, swelling ratio, tensile strength, percentage of strain at break, crystallinity, in vitro enzymatic degradation with lysozyme, and in vitro Vero cells adhesion. While the use of the most concentrated chitosan solution (2.5% w/w) increased membrane cost, it also improved the biomaterial mechanical resistance and ductility, as well as reduced membrane degradation when exposed for 2 months to lysozyme. The remaining evaluated properties were not affected by initial chitosan solution concentration. Chitin incorporation, on the other hand, reduced the membranes cost, swelling ratio, mechanical properties, and crystallinity, resulting in thicker biomaterials with irregular surface more easily degradable when exposed to lysozyme. Glycerol incorporation also reduced the membranes cost and crystallinity and increased membranes degradability after exposure to lysozyme. Strong Vero cells adhesion was not observed in any of the tested membrane formulations. The overall results indicate that the majority of the prepared membranes meet the performance requirements of temporary nonbiodegradable burn dressings (e.g. adequate values of mechanical resistance and ductility, low values of in vitro cellular adhesion on their surfaces, low extent of degradation when exposed to lysozyme solution, and high stability in aqueous solutions).

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“…After complete wetting of the film, the pH at the surface of film was checked using pH paper. [17] In vitro disintegration Two simple methods were used wherein, a small amount of disintegration medium was used. In the first method, one drop of water was dropped from a 10-ml pipette onto the tightly clamped film.…”

Section: Tensile Strengthmentioning

confidence: 99%

Formulation development of fast releasing oral thin films of levocetrizine dihydrochloride with Eudragit^®Epo and optimization through Taguchi orthogonal experimental design

Lakshmi¹,

Sridharan²,

Sreekanth³

2011

Asian J Pharm

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T he aim of this study was to develop a fast releasing oral polymeric film, prepared using the solvent casting method, with good mechanical properties, instant disintegration and dissolution, an acceptable taste in the oral cavity. Levocetirizine dihydrochloride, an antihistamine, was incorporated to relieve the symptoms of allergic rhinitis. Four batches of films with drug were prepared using different combinations of polymers and plasticizers Eudragit ® EPO, HPMC E 5 LV, and PVA were the selected polymers. Glycerin, dibutyl phthalate, propylene glycol, and PEG 400 were the selected plasticizers. The resultant films were evaluated for weight variation, assay, content uniformity, folding endurance, thickness, tensile strength, percent elongation, surface pH, in vitro disintegration and in vitro dissolution. The formulations from the preliminary trial were analyzed using Taguchi OA experimental design, which was applied to optimize the type of polymers, concentration of polymers, plasticizer, and sweetener based on their disintegration data at three different levels. The optimized films disintegrated in less than 30s, releasing 70-90% of drug within 2 mins. The percentage release varied with the type of polymer and concentration of polymer. The films made with EPO released 96% of drug in 2 mins, which was the best release among all.

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Solid-state and mechanical properties of aqueous chitosan-amylose starch films plasticized with polyols

Cited by 30 publications

References 24 publications

The Use of Electric Fields for Edible Coatings and Films Development and Production: A Review

The Use of Electric Fields for Edible Coatings and Films Development and Production: A Review

Effects of chitosan solution concentration and incorporation of chitin and glycerol on dense chitosan membrane properties

Formulation development of fast releasing oral thin films of levocetrizine dihydrochloride with Eudragit^®Epo and optimization through Taguchi orthogonal experimental design

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Solid-state and mechanical properties of aqueous chitosan-amylose starch films plasticized with polyols

Cited by 30 publications

References 24 publications

The Use of Electric Fields for Edible Coatings and Films Development and Production: A Review

The Use of Electric Fields for Edible Coatings and Films Development and Production: A Review

Effects of chitosan solution concentration and incorporation of chitin and glycerol on dense chitosan membrane properties

Formulation development of fast releasing oral thin films of levocetrizine dihydrochloride with Eudragit®Epo and optimization through Taguchi orthogonal experimental design

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Product

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About

Formulation development of fast releasing oral thin films of levocetrizine dihydrochloride with Eudragit^®Epo and optimization through Taguchi orthogonal experimental design