Solid Serous Adenoma of the Pancreas: A Case Report and Review of the Literature

Katsourakis, Anastasios; Dimitriou, Ioannis; Noussios, Georgios; Chatzis, Iosiph; Chatzitheoclitos, Efthimios

doi:10.1155/2016/3730249

Cited by 8 publications

(11 citation statements)

References 13 publications

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“…The mean size of lesions was 2.3 cm, which was smaller than that reported in the aforementioned studies. Of the five cases in the present study, four of them had biomarker expression levels (carcinoembryonic antigen, α-fetoprotein, CA19-9 and CA21-5 within the expected range; data not shown) within the normal range, and this was similar to previously published studies (3,8,16,18,19,21,22,23,25).…”

Section: Discussionsupporting

confidence: 92%

“…This was supported by a previously published case report with an exact preoperative diagnosis of SSC (16). In the current study, 2 masses exhibited wash-in and wash-out, which was similar to the majority of cases in previous studies (21,26), while 3 cases exhibited moderate, gradual and prolonged enhancement and spotted enhancement in the latter 2 phases, similar to a SSC case reported by Lee et al (17). The 80% marginal area was clearly observed to demonstrate strong enhancement, and this was reported in previously published studies (16,18,26).…”

Section: Discussionsupporting

confidence: 91%

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Computed tomography and magnetic resonance imaging features of solid serous cystadenomas of the pancreas

Chen

Pan

et al. 2019

Oncol Lett

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Solid serous cystadenomas (SSC) of the pancreas are the rarest benign type of serous cystic neoplasms and are frequently misdiagnosed, resulting in unnecessary invasive surgical procedures. A retrospective study was performed to collect imaging features of SSC using computed tomography (CT) and magnetic resonance imaging. The clinical data and imaging study of 5 female patients with pathologically confirmed SSC (mean age, 44.2 years; range, 23–69 years) diagnosed between January 2006 and July 2017 were retrospectively analyzed. The imaging study was assessed by two experienced radiologists in consensus. All patients had tumors with a mean size of 2.3 cm (range, 1.5–3.2 cm; 4/5 lesions ≤3 cm). The tumors were located in the tail of pancreas in 3 cases and in the neck of the pancreas in 2 cases. The tumors were all well defined, with an ovoid and lobulated shape and fibrous capsules. Consequently, they presented as low density on unenhanced CT images, marked hyperintensity on T2-weighted images in 4 cases and slight hyperintensity in 1 case. However, they exhibited heterogeneous wash-in and wash-out enhancement in 2 cases and moderate and prolonged enhancement in 3 cases. The apparent diffusion coefficient (ADC) values of the lesions were >2×10 −3 mm 2 /sec. Therefore, a small tumor size, signal intensity on T2-weighted images, high ADC values, fibrous capsules and enhancement patterns may be indicative imaging features of SSCs.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Computed tomography and magnetic resonance imaging features of solid serous cystadenomas of the pancreas

Chen

Pan

et al. 2019

Oncol Lett

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“…We excluded the nonsurgical cases. To our knowledge, only 19 cases including our case have been published with a pathological confirmation ( Table I ) ( 2 , 3 , 5 , 8 – 19 ).…”

Section: Discussionmentioning

confidence: 97%

“…On the other hand, the solid type accounts for only 3% of all SCAs in a Japanese multicenter study ( 1 ), and it is described as noncystic, meaning that a cystic structure is too tiny to be detected macroscopically. Solid SCA is usually misdiagnosed preoperatively as neuroendocrine tumor (NET) ( 2 ). In several case reports, the authors reported that magnetic resonance cholangiopancreatography (MRCP) might be useful for preoperative diagnosis of SCA ( 3 – 5 ).…”

Section: Introductiommentioning

confidence: 99%

Middle segment pancreatectomy for a solid serous cystadenoma diagnosed by MRCP and review of the literature: A case report

et al. 2018

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Solid serous cystadenoma of the pancreas is the rarest subtype of serous cystadenoma. Cystic structures are difficult to recognize by imaging studies. In the clinical setting, it is crucial to discriminate a solid serious cystadenoma from other solid pancreatic tumors. The present study reported a case of solid serous cystadenoma in which the magnetic resonance cholangiopancreatography (MRCP) findings were useful for diagnosis and decision-making regarding the surgical strategy, with a review of the previous reports of solid serous cystadenoma. A 50-year-old woman was referred to our hospital for investigation of a pancreatic body mass. A 2-cm hypervascular solid tumor was revealed by computed tomography. No typical radiological imaging findings of small cysts were detected, such as a honeycomb structure, and an adequate specimen could not be gained by biopsy under endoscopic ultrasonography. However, the tumor showed high intensity on MRCP, suggesting its cystic nature. A solid serous cystadenoma was suspected based on these radiological findings, and middle segment pancreatectomy was performed as a function-preserving surgery. The histological findings were compatible with a solid serous cystadenoma. In conclusion, MRCP imaging may be helpful for diagnosis and decision-making regarding the most appropriate surgical method for solid serous cystadenomas.

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“…Microscopically, the solid variant of SC is composed of closely packed, small, uniform tubules, and acini with little or no lumina formation. 4 , 22 Turcotte et al 23 reported 10 (18.2%) cases of solid microcystic SC in a cohort of 55 VHL patients with SC. A few cases in our study grossly showed solid areas, but this appearance was not predominant on the cut surface of the lesion and these tumors did not meet the criteria for “solid variant” of SC.…”

Section: Discussionmentioning

confidence: 99%

Serous cystadenoma of pancreas: A clinicopathologic experience of 23 cases from a major tertiary care center

et al. 2018

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Background:Serous cystadenomas of pancreas are rare benign epithelial neoplasms, which predominantly occur in the pancreatic body and tail of elderly females. Majority of these tumors have microcystic appearance. Macrocystic and solid variants have also been described. A number of more aggressive cystic pancreatic lesions are included in the differential diagnosis. Distinction from such lesions is important for optimal management.Objective:Our aim was to study the clinical and histological features of serous cystadenomas which would be helpful in making their correct diagnosis and understanding their behavior.Methods:We reviewed 23 cases of serous cystadenomas diagnosed in our institution between January 2001 and June 2018.Results:Mean age at presentation was 53.43 years. Female to male ratio was 4.75:1. Over half (56.5%) of the cases were diagnosed incidentally. Abdominal pain was the most common symptom. Body and tail (either alone or in combination) were the most common locations. Tumor size ranged from 2 to 16 cm. Central scar was seen in 43.4% cases. Two cases were unilocular (macrocystic). Microscopically, all cases showed simple cuboidal to flattened epithelium with round, uniform nuclei, and glycogen-rich clear cytoplasm. Focal micropapillae formation was seen in eight cases (34.7%). Surgical resection was performed in 82.6% cases. Recurrence occurred in only one single case.Conclusion:Pancreatic serous cystadenomas are benign neoplasms with excellent prognosis. The tumors showed typical morphological features in all cases. Surgical resection was performed in the majority of cases in our study owing to lack of optimal and complete radiological workup pre-operatively and the concern for not missing and adequately treating pancreatic mucinous cystic neoplasms.

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Solid Serous Adenoma of the Pancreas: A Case Report and Review of the Literature

Cited by 8 publications

References 13 publications

Computed tomography and magnetic resonance imaging features of solid serous cystadenomas of the pancreas

Computed tomography and magnetic resonance imaging features of solid serous cystadenomas of the pancreas

Middle segment pancreatectomy for a solid serous cystadenoma diagnosed by MRCP and review of the literature: A case report

Serous cystadenoma of pancreas: A clinicopathologic experience of 23 cases from a major tertiary care center

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