Solid Self‐Emulsifying Delivery System (S‐SEDS) of Dihydromyricetin: A New Way for Preparing Functional Food

Abstract

The present study was aimed at formulating and evaluating a novel solid self-emulsifying delivery system (S-SEDS) for the application in functional foods of dihydromyricetin (DMY). First, solubility study and pseudo-ternary phase diagram analysis were adopted to optimize the formulation of liquid self-emulsifying delivery system (L-SEDS). And the thermodynamic stable L-SEDS with 5% content of DMY was fabricated and further developed into a solid form via vacuum rotary evaporation with Aerosil 300 as the solid adsorbent. Solid state characterization of the S-SEDS was performed by scanning electron microscopy, Fourier-transform infrared spectroscopy, and X-ray powder diffraction. Furthermore, studies proved that the antioxidant activity and bioaccessibility of DMY were improved after incorporated into S-SEDS formulation compared to pure DMY. The S-SEDS showed good resistance against various storage conditions investigated for 10 weeks.Practical Application: Solid self-emulsifying delivery system (S-SEDS) combined the advantages of liquid self-emulsifying delivery system with those of a solid dosage form to overcome the disadvantages associated with liquid formulations is more convenient for storage and transportation in practical application. Furthermore, the technology of producing S-SEDS is simple and can be realized in industrial production. Hence, S-SEDS could be a promising strategy to overcome the poor water solubility and short biological half-life of dihydromyricetin for further application in functional foods and beverage industry.

Reactive oxygen species induced by plant essential oil for effective degradation of p-phenylenediamine

“…17 The HR and CI no more than 1.25 and 21, respectively, prove that the powders have good flowability and are applicable to industrial production. 26 The angle of repose, HR and CI of BC/SE-OPEO are listed in Table 4. The results of the three parameters all conform to the above demands and as such it is considered that the prepared BC/SE-OPEO possesses good fluidity.…”

Progress in the Application of Food-Grade Emulsions

“…Self-emulsifying formulation, composed of an oil, a surfactant, and a cosolvent, was easily produced on a large scale and exhibited a high carrying capacity, which resulted in an enhanced bioavailability and efficacy for the active substances. As an example, Wang et al [ 6 ] prepared a solid self-emulsifying system for the delivery of dihydromyricetin, which allowed them to overcome the poor water solubility and short biological half-life of this substance, thereby improving its antioxidant performance and bioavailability and providing a feasible solution for its application in foods and beverages. In addition, Pickering emulsions have been used to encapsulate flavor compounds to hinder their volatilization and oxidative degradation whilst also promoting their effective dispersion into commodities to achieve continuous aroma release [ 7 ].…”

Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges

“…Then DHM-loaded solid self-microemulsion (DHM/S-SEDS) was prepared by adsorbing DHM/L-SEDS onto the solid adsorbent Aerosil 300. In vitro and in vivo experiments showed that DHM/S-SEDS improved the antioxidant activity and bioavailability of DHM, and showed good fluidity and stability under various storage conditions within 10 weeks (Wang et al., 2019 ). Theoretically, the increase in the specific surface area, the number of voids, and the depth of pores in the particle may lead to the difficulty of drug dissolution and the spontaneous aggregation of drug molecules (i.e.…”