Solid pseudopapillary tumor of the pancreas with liver metastasis: Clinical features and management

Wang, Weibin; Zhang, Taiping; Sun, Mingshu; Zheng, Peng; Chen, Ge; Zhao, Yupei

doi:10.1016/j.ejso.2014.05.012

Cited by 33 publications

(26 citation statements)

References 19 publications

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“…To date, there have been no reported case of liver metastasis in SPTs <3 cm in diameter (Table 1). 1,[6][7][8][9][10][11] In consideration of the high female predilection of SPTs, the occurrence of this tumor in our patient was unusual; therefore, it was not initially considered in the differential diagnosis in this case. Accurate preoperative diagnosis of an SPT is challenging.…”

Section: Discussionmentioning

confidence: 99%

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An Unusual Presentation of a Solid Pseudopapillary Tumor of the Pancreas Mimicking Adenocarcinoma

2020

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Solid pseudopapillary tumors of the pancreas are rare and typically occur in young women. Compared with pancreatic adenocarcinoma, solid pseudopapillary tumors are characterized by notable indolent biological behavior associated with a favorable prognosis. Despite their large size, these tumors rarely metastasize. Even in cases of hepatic metastasis, most lesions are usually solitary in distribution and are amenable to resection. We report a case of a 55-year-old man with a small solid pseudopapillary tumor (≤3-cm diameter) mimicking a pancreatic adenocarcinoma, with multiple hepatic metastases. The diagnosis was confirmed by endoscopic ultrasoundguided fine-needle biopsy using a 22-G core needle. Unfortunately, rapid tumor progression led to patient mortality 5 months after diagnosis. To our knowledge, this is the first case report that describes a small solid pseudopapillary tumor of the pancreas with multiple hepatic metastasis and poor prognosis in a patient who was diagnosed with this condition at the time of initial diagnosis. Clin Endosc Nov 22. [Epub ahead of print]

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Section: Discussionmentioning

confidence: 99%

“…Surgery is the treatment of choice for SPTs, and metastasectomy should also be considered if possible. 10,17 In patients with unresectable SPT, there is no consensus on treatment. Maffuz et al reported an unresectable SPT treated effectively by surgical resection after preoperative chemotherapy with fluorouracil and radiation.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Presentation of a Solid Pseudopapillary Tumor of the Pancreas Mimicking Adenocarcinoma

2020

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“…The liver is the most common organ affected by SPT metastases. Liver metastases can be discovered at diagnosis or even at 10–15 years postoperatively [44,45]. …”

Section: Discussionmentioning

confidence: 99%

Solid pseudopapillary tumor of the pancreas: clinical-pathological features and management of 13 cases

Bochis

Bota

Mihut

et al. 2017

Medicine and Pharmacy Reports

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Background and aimSolid pseudopapillary tumor (SPT) of the pancreas is a rare pathological condition, representing less than 3% of all exocrine pancreatic tumors. SPT usually occurs in young females, without notable symptoms, with a low malignant potential and excellent prognosis.MethodWe conducted a retrospective study during the period January 2005 – January 2015. SPT patients admitted in our institution were reviewed by describing demographic data, clinico-pathologic and radiological features, therapeutic management and prognosis records.ResultsThirteen patients with SPT were identified (10 females), with a median age of 30 years. The main clinical presentation was abdominal pain (92.3%). The tumor was mostly located in the body or tail of the pancreas (77%), and the mean size was 8.2 cm. Regarding the surgical approach there were 5 distal pancreatectomies with splenectomy, 3 body and tail pancreatectomies, 2 body and tail pancreatectomies with splenectomy, 2 pancreato-duodenectomy, 1 partial enucleation and of all only 2 partial resections. Postoperative hematoxylin- eosin staining and immunohistochemistry confirmed the diagnosis in all cases. None of the patients had lymph nodes metastases. Only one local invasion. There was one case of death due to postoperative complications. Four cases followed adjuvant systemic chemotherapy. The mean follow-up was 18 months, without evidence of recurrence during this period.ConclusionSPT should always be considered in the differential diagnosis in young women with a pancreatic tumor. Complete surgical excision is the treatment of choice, and is usually curative. The decision to administer systemic therapy must be individualized. Malignant behavior and late recurrences mandates long-term follow-up for patients with SPT.

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“…Solid pseudopapillary tumors (SPTs) of the pancreas that presenting predominantly in young female patients are the neoplasms of low malignant potential in exocrine pancreas (Lee et al ., ; Yagcı et al ., ; Mahida et al ., ). In accordance with the 2000 World Health Organization (WHO) classification system, pancreatic SPTs are usually defined as epithelial tumors composed of monomorphic cells surrounding delicate blood vessels and forming a solid mass as well as pseudopapillary structures, frequently showing hemorrhage, and cystic degeneration (Coleman et al ., ; Wang et al ., ). Approximately 75–80% of SPT of the pancreas is developed from the pancreas, but may occasionally be invasions of the adjacent organs or distant metastasis, such as the liver, lymph node mesentery, omentum, and peritoneum (Papavramidis and Papavramidis, ; Yin et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Two-photon excited fluorescence imaging of the pancreatic solid pseudopapillary tumor without hematoxylin and eosin stains

Liao

Chen

et al. 2015

Scanning

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Solid pseudopapillary tumor (SPT) of the pancreas is an epithelial tumor with low-grade malignant potential and present more common in females. At present, the gold standard for accurate diagnosis of pancreatic tumor was mostly depending on the pathological and/or cytological evaluation. In this work, TPEF microscopy was applied to obtain the images of human normal pancreas and SPT of the pancreas without hematoxylin and eosin (H&E) staining, for the purpose of identifying the organization structural, cell morphological, and cytoplasm changing, which were then compared to their corresponding H&E stained histopathological results. Our results showed that high-resolution TPEF imaging of the pancreatic SPT can clearly distinguish the pathological features from normal pancreas in unstained histological sections, and the results are consistent with the histological results. Moreover, we measured the nuclear-cytoplasmic ratios of the pancreatic SPT and normal pancreas to characterize their difference in the cytomorphological feature. It indicated that this technique can achieve the consistent information of pathological diagnosis, and has the potential to substantially improve the optical diagnosis and treatment of the pancreatic SPT without H&E staining in the future. SCANNING 38:245-250, 2016. © 2015 Wiley Periodicals, Inc.

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Solid pseudopapillary tumor of the pancreas with liver metastasis: Clinical features and management

Cited by 33 publications

References 19 publications

An Unusual Presentation of a Solid Pseudopapillary Tumor of the Pancreas Mimicking Adenocarcinoma

An Unusual Presentation of a Solid Pseudopapillary Tumor of the Pancreas Mimicking Adenocarcinoma

Solid pseudopapillary tumor of the pancreas: clinical-pathological features and management of 13 cases

Two-photon excited fluorescence imaging of the pancreatic solid pseudopapillary tumor without hematoxylin and eosin stains

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