Solid-pseudopapillary Tumor of the Pancreas

Seo, Hyang-Eun; Lee, Myung-Kwon; Lee, Young-Doo; Jeon, Seong Woo; Cho, Chang-Min; Tak, Won Young; Kweon, Young-Oh; Kim, Sung-Kook; Choi, Yun‐Sang; Bae, Han Ik; Kim, Sang Geol; Yoon, Young-Kook

doi:10.1097/01.mcg.0000225671.91722.10

Cited by 24 publications

(18 citation statements)

References 13 publications

(29 reference statements)

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“…[10152122] For tumors with aggressive histological features, adjuvant chemotherapy (gemcitabine and cisplantin-based neoadjuvant chemotherapy) is advocated in addition to surgery. [23] Seo et al .…”

Section: Discussionmentioning

confidence: 99%

Solid and cystic papillary neoplasm of pancreas: A clinic-pathological and immunohistochemical study: A tertiary care center experience

Patnayak¹,

Jena²,

Parthasarathy³

et al. 2013

South Asian J Cancer

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Background:Solid pseudopapillary tumor of the pancreas (SPT) is a rare tumor of low malignant potential, mostly described in young women.Materials and Methods:In this retrospective study from January 2000 - December 2010, there were 50 pancreatic tumors. In this period, four SPTs were encountered, which were analyzed with respect to clinical, imaging, histopathological, and immunohistochemical findings.Results:There was a female preponderance with mean age of 22.2 years. Two of the tumors were located in head of the pancreas and two in the body and tail region. On imaging, majority were large cystic tumors. Histopathologically, they exhibited extensive necrosis and presence of pseudo papillae in viable areas. Immunohistochemically, they were positive for alpha-1-anti-trypsin, alpha-1-anti-chymotrypsin, vimentin, CD10, and CD99. Progesterone receptor and p53 exhibited mild positivity in all of the four cases, whereas neuron specific enolase (NSE), synaptophysin, and chromogranin showed focal positivity in one case.Conclusion:Despite its non-specific clinical, imaging, and even immunohistochemical features, characteristic gross and microscopic findings provide reliable diagnosis of SPTs.

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Section: Discussionmentioning

confidence: 99%

Solid and cystic papillary neoplasm of pancreas: A clinic-pathological and immunohistochemical study: A tertiary care center experience

Patnayak¹,

Jena²,

Parthasarathy³

et al. 2013

South Asian J Cancer

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“…[125][126][127][128][129][130][131] Characteristically, there is an intense desmoplastic reaction in the stroma surrounding these tumours. Sixty-five per cent are located within the head, 15% in the body, 10% in the tail and 10% are multifocal.…”

Section: Pathology Staging and Resection Margins (Box 4)mentioning

confidence: 99%

“…Histological variants of malignant tumours of the exocrine pancreas[125][126][127][128][129][130][131] …”

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confidence: 99%

Biology and management of pancreatic cancer

Ghaneh

Costello

Neoptolemos

2008

Postgraduate Medical Journal

272

274

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“…Patients with SPTP have a favorable prognosis after complete excision, with a 5-year survival rate of 85%. Even the 15% of patients with recurrent SPTP or with liver or peritoneal metastasis or invasion generally have good long-term survival (3)(4)(5).…”

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confidence: 99%

Proteomic Analysis of Solid Pseudopapillary Tumor of the Pancreas Reveals Dysfunction of the Endoplasmic Reticulum Protein Processing Pathway

Zhu

Chen

et al. 2014

Molecular & Cellular Proteomics

101

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Solid pseudopapillary tumor of the pancreas (SPTP) is a low-grade malignant tumor with a favorable prognosis after surgery. Many previous studies have focused on clinical features or pathological biomarkers of the disease, but a better understanding of the molecular mechanisms underlying SPTP may help guide future therapeutic strategies. Here, we used isobaric tags for relative and absolute quantitation (iTRAQ) technology integrated with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to identify differentially expressed proteins in SPTP specimens. A total of 1171 proteins with a threshold of a 1.5-fold change and a p value < 0.05 between SPTP tissue and matched normal pancreas tissue were identified for bioinformatics analysis. Mass spectrometry results were then further confirmed by assessing six representative proteins (ACADL, EPHX2, MSI2, DKK4, JUP, and DAD1) in individual specimens with immunohistochemistry. Upon mapping of the differentially expressed proteins to the Kyoto Encyclopedia of Genes and Genomes pathways database, we found several new celladhesion molecules that could be used as pathologic biomarkers. Furthermore, we observed that many endoplasmic reticulum-associated proteins were altered, suggesting that endoplasmic reticulum stress may play an important role in SPTP tumorigenesis. Seven proteins (ERO1LB, TRIM1, GRP94, BIP, SEC61B, P4HB, and PDIA4) in this pathway were further validated by immunohistochemistry, and six of them Solid pseudopapillary tumor of the pancreas (SPTP)1 is an uncommon epithelial neoplasm of low malignant potential that occurs predominantly in young women. It was first described by Frantz in 1959 as a solid and cystic lesion that was previously misdiagnosed as a rare islet tumor or as an acinar cell carcinoma (1). The incidence of SPTP is relatively low and accounts for ϳ1-2% of all pancreatic tumors. Most patients with the disease do not have significant symptoms until the volume of the tumor is very large or present with other complications. In 1996, the World Health Organization (WHO) reclassified SPTP as a low-grade malignant tumor because of its biological behavior (2). Fortunately, the tumor is confined to the pancreas in 85% of patients. Patients with SPTP have a favorable prognosis after complete excision, with a 5-year survival rate of 85%. Even the 15% of patients with recurrent SPTP or with liver or peritoneal metastasis or invasion generally have good long-term survival (3-5).The reported incidence of SPTP has increased with improved detection methods in the last decade, and much pathologic and clinical effort has been aimed at understanding the origin and development of SPTP. In a large-scale study at Ruijin Hospital, a total of 82 cases of SPTP were studied retrospectively. The authors concluded that SPTP with incomplete capsules often presented with malignant behavior and hypothesized that SPTP was probably caused by disordered pancreatic stem cell development (6). Another group at the University of Kiel analyzed 59 patients and postul...

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Solid-pseudopapillary Tumor of the Pancreas

Abstract: SPT of the pancreas is an unusual neoplasm and typically occurs in young females presenting well-demarcated pancreatic masses, which are amenable to cure by complete surgical resection.

Cited by 24 publications

References 13 publications

Solid and cystic papillary neoplasm of pancreas: A clinic-pathological and immunohistochemical study: A tertiary care center experience

Solid and cystic papillary neoplasm of pancreas: A clinic-pathological and immunohistochemical study: A tertiary care center experience

Biology and management of pancreatic cancer

Proteomic Analysis of Solid Pseudopapillary Tumor of the Pancreas Reveals Dysfunction of the Endoplasmic Reticulum Protein Processing Pathway

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