Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients

Yang, Feng; Jin, Chen; Jiang, Long; Lei, Yu; Xu, Jin; Yang, Di; Ji, Li; Fu, De Liang; Ni, Quan Xing

doi:10.1016/j.amjsurg.2008.07.062

Cited by 97 publications

(88 citation statements)

References 11 publications

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“…10 Yang and colleagues 7 reported that in 2 of 26 patients with malignant SPN, the expression of Ki-67 was positive; however, expression of K1-67 was negative in the 24 patients with nonmalignant SPN, suggesting that Ki-67 might be a marker of malignant potential. In our further research, we will explore the relation between Ki-67 and malignant potential of SPN tumours.…”

Section: Researchmentioning

confidence: 99%

Diagnosis and surgical treatment of solid pseudopapillary neoplasm of the pancreas: analysis of 24 cases

Guo

Zhou²,

Chen³

et al. 2011

Can J Surg

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RESEARCH • RECHERCHEDiagnosis and surgical treatment of solid pseudopapillary neoplasm of the pancreas: analysis of 24 cases Background: Our aim was to summarize our experience with the diagnosis and surgical treatment of solid pseudopapillary neoplasm (SPN) of the pancreas to provide a reference for the management of this rare condition. Methods:We collected and analyzed retrospective data on the clinical presentation, laboratory investigations, radiologic imaging, pathology and operative details of pa tients with SPN of the pancreas diagnosed between February 2001 and December 2009. Results:In all, 23 of 24 patients were women, and the mean age of all patients was 31 years. The most common clinical presentation was vague abdominal pain. Abdominal imaging showed solid or solid cystic masses in the pancreas, mostly in the tail or head of the gland. All patients were treated surgically. There were no postoperative deaths. After follow-up ranging from 4 to 109 months (median 68 mo), 20 of 22 patients who underwent curative resection were alive with no evidence of disease recurrence. Of the 2 patients with R1 resections, 1 died 42 months after surgery, whereas the other underwent a second operation and was alive after 36 months' follow-up. Conclusion:Solid pseudopapillary neoplasm of the pancreas is a relatively indolent tumour. The initial diagnosis of SPN of the pancreas is suggested by radiologic imaging findings but should be considered in the context of clinical and histopathologic characteristics. We advocate for complete surgical resection once SPN is diagnosed.Contexte : Nous voulions résumer notre expérience du diagnostic et du traitement chirurgical du néoplasme pseudo-papillaire solide (NPS) du pancréas afin d'établir un point de référence pour la prise en charge de ce problème rare.

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Section: Researchmentioning

confidence: 99%

Diagnosis and surgical treatment of solid pseudopapillary neoplasm of the pancreas: analysis of 24 cases

Guo

Zhou²,

Chen³

et al. 2011

Can J Surg

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“…However, approximately 15-20% of cases of SPN manifest with malignant behavior, including perineural or vascular infiltration and metastasis (22,23). Fatal cases of recurrence have been reported (24). Therefore, the diagnosis of SPN and subsequent surgical resection should be performed without delay.…”

Section: Discussionmentioning

confidence: 99%

Solid Pseudopapillary Neoplasm of the Pancreas Associated with Familial Adenomatous Polyposis

et al. 2015

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A man in his thirties visited our hospital for an evaluation of a 12×10-mm pancreatic solid tumor that was accidentally detected on computed tomography performed for follow-up of familial adenomatous polyposis (FAP). We diagnosed the patient with a solid pseudopapillary neoplasm (SPN) based on endoscopic ultrasound-guided fine-needle aspiration, and he underwent pancreaticoduodenectomy. Small SPN tumors appear as solid tumors, without typical features of SPN, making the definitive diagnosis more difficult. The genetic background of FAP patients can predispose them to SPN, and imaging of the pancreas should be performed at prescribed intervals in FAP patients.

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“…Ki-67 expression may correlate to some extent with 'malignancy' or local invasion of SPN [20,57,71,93,116]. In some reports, Ki-67 expression was documented only in cases with invasion of pancreatic parenchyma [93,116].…”

Section: Discussionmentioning

confidence: 99%

“…Some nuclear morphometric features may also be useful for prediction of clinical aggressiveness of SPN as well [69]. Some researchers tested IHC stains as potential predictors of aggressive behavior: CD10, CD56, PgR, synaptophysin, p53, Ki-67, α1-antitrypsin, α1-antichymotrypsin, neuron-specific enolase, galectin-3, vimentin, chromogranin, pan-cytokeratin, Cam5.2, and epithelial membrane antigen (EMA) [11,24,32,33,70,71].…”

Section: Literature Searchmentioning

confidence: 99%

Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas

Liszka

Mrowiec²,

Pająk³

et al. 2014

pjp

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Solid-pseudopapillary neoplasms (SPN) are rare tumours of the pancreas. Distant metastases and/or local recurrence following surgical resection occur in 10% to 15% of patients with SPN. In the present study, we aimed to systematically examine the usefulness of virtually all histopathological features of SPN which were previously considered potential risk factors of clinically aggressive behaviour of SPN following surgical resection. Seventeen SPN were included. None of the cases had an undifferentiated component. Follow-up data were available for 14 patients (median 52 months). One patient developed liver metastasis 17 months after resection of the primary tumour and fulfilled the criteria of a clinically aggressive disease. None of the histopathological features allowed identification of that case with an adequate diagnostic yield. At present, histopathological examination cannot identify patients who may develop tumour recurrence following resection of the primary lesion. A close follow-up should be offered to all patients treated for SPN.

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Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients

Cited by 97 publications

References 11 publications

Diagnosis and surgical treatment of solid pseudopapillary neoplasm of the pancreas: analysis of 24 cases

Diagnosis and surgical treatment of solid pseudopapillary neoplasm of the pancreas: analysis of 24 cases

Solid Pseudopapillary Neoplasm of the Pancreas Associated with Familial Adenomatous Polyposis

Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas

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