Solid pseudopapillary tumor of the pancreas in children: typical radiological findings and pathological correlation

Alqahtani, Saad M; Gudinchet, F.; Laswed, T.; Schnyder, P.; Schmidt, Sabine; Osterheld, Maria‐Chiara; Alamo, Leonor

doi:10.1016/j.clinimag.2009.06.024

Cited by 26 publications

(16 citation statements)

References 15 publications

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“…Notably, 8 of our patients were younger than 18 years (15.6%), in keeping with other reports in the literature that have suggested that SPN may account for 8% to 16.6% of pancreatic tumors in children. 16 …”

Section: Discussionmentioning

confidence: 99%

Institutional Experience With Solid Pseudopapillary Neoplasms

Raman¹,

Kawamoto²,

Law³

et al. 2013

Journal of Computer Assisted Tomography

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Objective Solid pseudopapillary neoplasms (SPNs) are low-grade malignancies with an excellent prognosis, albeit with the potential for metastatic disease. This study details our institution's experience with the diagnosis and treatment of SPN, including clinical presentation, multimodality imaging findings, and potential predictors of aggressive tumor behavior. Materials and Methods The institutional pathology database was searched through for all cases of SPN since 1988, yielding 51 patients. The electronic medical record was searched for clinical and demographic information regarding these patients, including age, sex, presenting symptoms, type of surgery, postoperative length of stay, tumor markers, and postsurgical follow-up. All available imaging data were reviewed, including those of 30 patients who underwent multidetector computed tomography, those of 9 patients who underwent magnetic resonance imaging (MRI), those of 3 patients who underwent conventional ultrasound, and those of 11 patients who underwent endoscopic ultrasound. Results A total of 84% of patients were females, with a mean age of only 33 years. Prognosis was excellent, with a mean follow-up of 3 years without recurrence. Only 1 of the 51 patients developed metastatic disease to the liver 8 years after the surgery. On computed tomography, lesions tended to be large (5.3 cm), well circumscribed (29/30), round/oval (20/30), and encapsulated (23/30). The lesions often demonstrated calcification (14/30) and typically resulted in no biliary or pancreatic ductal dilatation. The lesions ranged from completely cystic to completely solid. On MRI, the lesions often demonstrated a T2 hypointense or enhancing capsule (6/9) and demonstrated internal blood products (5/9). The lesions tended to be devoid of vascularity on conventional ultrasound. Ten patients were found to have “aggressive” histology at presentation (T3 tumor, nodal involvement, perineural invasion, or vascular invasion). No demographic, clinical, or multidetector computed tomographic imaging features were found to correlate with aggressive histology. Conclusions Certain imaging features (eg, well-circumscribed mass with calcification, peripheral capsule, internal blood products, and lack of biliary/pancreatic ductal obstruction) on computed tomography and MRI are highly suggestive of the diagnosis of SPN, particularly when visualized in young female patients. However, it is not possible to predict aggressive histology on the basis of imaging findings, clinical presentation, or patient demographic features.

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Section: Discussionmentioning

confidence: 99%

Institutional Experience With Solid Pseudopapillary Neoplasms

Raman¹,

Kawamoto²,

Law³

et al. 2013

Journal of Computer Assisted Tomography

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“…MRI should be considered the best imaging technique for children due to the absence of radiation and its improved capacity for visualizing tumor components, especially intratumoral areas of hemorrhage. Both the fibrous capsule and the intramural hemorrhage are important clues for the final diagnosis because they are rarely found in other pancreatic neoplasms [16].…”

Section: Discussionmentioning

confidence: 99%

Solid Pseudopapillary Neoplasm of the Pancreas in a 15-Year-Old Female: A Case Report

Sheikh¹

2015

Trop Med Surg

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“…In our case, the patient was diagnosed as SPT after typical CT scan appearance with clinical history of a young girl. MRI is the best imaging technique for children due to reduce risk of radiation and better visualisation of central haemorrhage 17. Both central haemorrhage and peripheral fibrous pseudocapsule (heterogenous signal intensity in T2-weighted image and low signal intensity in T1-weighted image, but usually enhance after gadolinium application) are important findings or correct diagnosis because the features are very unusual in other pancreatic tumours 17…”

Section: Discussionmentioning

confidence: 99%

Solid-pseudopapillary carcinoma: a case study and literature review

et al. 2012

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Solid-pseudopapillary tumour (SPT) is a rare exocrine tumour of the pancreas and is considered to have low malignant potential. Few morphological criteria are used to predict malignant behaviour such as equivocal perineural invasion, angioinvasion and invasion to surrounding tissue, and should be designated as solid-pseudopapillary carcinoma (SPC). We report a case of SPC. Clinical and radiological findings are typical for SPT with no metastatic disease. There is no tumour recurrence after 4 months postresection. Clinical history and radiological findings were retrieved from the patient's record sheet and Viarad system. H&E staining and few immunoproxidase staining were reviewed by several pathologists. The histological findings are typical for SPT, with additional perineural invasion. There is no angioinvasion or capsular invasion identified. This is our first experience in diagnosing and managing SPC. We look forward to seeing the patient's disease status during her next routine follow-up. We expect good disease-free survival and very low risk of tumour recurrence, in view of only one risk factor (perineural invasion) and uninvolved surgical margins by the tumour.

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Solid pseudopapillary tumor of the pancreas in children: typical radiological findings and pathological correlation

Cited by 26 publications

References 15 publications

Institutional Experience With Solid Pseudopapillary Neoplasms

Institutional Experience With Solid Pseudopapillary Neoplasms

Solid Pseudopapillary Neoplasm of the Pancreas in a 15-Year-Old Female: A Case Report

Solid-pseudopapillary carcinoma: a case study and literature review

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