Solid pseudopapillary tumor of the pancreas in male patients: Report of 16 cases

Cai, Yunqiang; Xie, Sheng‐Xue; Ran, Xun; Wang, Xing; Mai, Gang; Liu, Xu-Bao

doi:10.3748/wjg.v20.i22.6939

Cited by 47 publications

(53 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most frequent symptoms in our series were abdominal pain or discomfort, followed by abdominal mass; 2 patients were asymptomatic. These findings are well in accordance with previous reports [7–9]. Preoperative diagnosis of SPTs is generally made by CT or MRI imaging.…”

Section: Discussionsupporting

confidence: 92%

“…Machado et al [6] observed that SPTs in male patients were more aggressive than those in female patients, and they should be managed more radically. On the contrary, Cai et al [7]. collected 16 male patients with SPTs, and observed that males were older than female patients and had a favorable outcome after surgery, with no recurrence or death of disease in the follow-up.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Solid-Pseudopapillary Tumor of the Pancreas: A Single Center Experience

Beltrame

Pozza

Bona

et al. 2016

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Aim of this study was to review the institutional experience of solid-pseudopapillary tumors of the pancreas with particular attention to the problems of preoperative diagnosis and treatment. From 1997 to 2013, SPT was diagnosed in 18 patients among 451 pancreatic cystic neoplasms (3.7%). All patients underwent preoperative abdominal ultrasound, computed assisted tomography, and tumor markers (CEA and CA 19-9) determinations. In some instances, magnetic resonance, positron emission tomography, and endoscopic ultrasound with aspiration cytology were performed. There were two males and 16 females. Serum CA 19-9 was slightly elevated in one case. Preoperative diagnosis was neuroendocrine tumor (n = 2), mucinous tumor (n = 2), and SPT (n = 14). Two patients underwent previous operation before referral to our department: one explorative laparotomy and one enucleation of SPT resulting in surgical margins involvement. All patients underwent pancreatic resection associated with portal vein resection (n = 1) or liver metastases (n = 1). One patient died of metastatic disease, 77 months after operation, and 17 are alive and free with a median survival time of 81.5 months (range 36–228 months). Most of SPT can be diagnosed by CT or MRI, and the role of other diagnostic tools is very limited. We lack sufficient information regarding clinicopathologic features predicting prognosis. Caution is needed when performing limited resection, and long and careful follow-up is required for all patients after surgery.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Solid-Pseudopapillary Tumor of the Pancreas: A Single Center Experience

Beltrame

Pozza

Bona

et al. 2016

Gastroenterology Research and Practice

View full text Add to dashboard Cite

show abstract

“…Although less common than in females, male patients with SPN are recognized. Aggressive behavior of SPNs, both histologically and clinically, in male patients has been reported previously in some studies and reviews, although another study did not arrive at the same conclusion . None of these studies comparing male with female patients analyzed either CTNNB1 or APC genes for variants, although Machado et al found somatic KRAS variants in a male patient …”

Section: Discussionmentioning

confidence: 85%

“…Aggressive behavior of SPNs, both histologically and clinically, in male patients has been reported previously in some studies and reviews, 36,37 although another study did not arrive at the same conclusion. 38 None of these studies comparing male with female patients analyzed either CTNNB1 or APC genes for variants, although Machado et al found somatic KRAS variants in a male patient. 36 One of the six tumors in our study does not harbor detectable variants in CTNNB1, APC or any of the 50 genes tested, despite having nuclear beta-catenin expression.…”

Section: Discussionmentioning

confidence: 99%

Targeted next generation sequencing of pancreatic solid pseudopapillary neoplasms show mutations in Wnt signaling pathway genes

Wang

Gerrard

Poskitt

et al. 2019

Pathology International

View full text Add to dashboard Cite

Solid pseudopapillary neoplasms of the pancreas are rare neoplasms that have been shown to harbor recurrent somatic pathogenic variants in the beta‐catenin gene, CTNNB1. Here, we used targeted next generation sequencing to analyze these tumors for other associated mutations. Six cases of solid pseudopapillary neoplasms were studied. DNA extracted from formalin‐fixed paraffin embedded tissue blocks was analyzed using the Ion Torrent platform, with the 50‐gene Ampliseq Cancer Hotspot Panel v2 (CHPv2), with further variant validation performed by Sanger sequencing. Four tumors (67%) were confirmed to harbor mutations within CTNNB1, two with c.109T > G p.(Ser37Ala) and two with c.94G > A p.(Asp32Asn). One case showed a frameshift deletion in the Adenomatous Polyposis Coli gene, APC c.3964delG p.(Glu1322Lysfs*93) with a variant allele frequency of 42.6%. Sanger sequencing on non‐tumoral tissue confirmed the variant was somatic. The patient with the APC mutation developed metastasis and died. In addition to the four cases harboring CTNNB1 variants, we found a case characterized by poor outcome, showing a rare frameshift deletion in the APC gene. Since the APC product interacts with beta‐catenin, APC variants may, in addition to CTNNB1, contribute to the pathogenesis of solid pseudopapillary neoplasms via the Wnt signaling pathway.

show abstract

“…Solid pseudopapillary tumor (SPT) is considered as a rare pathological entity of the pancreas in children that generally has a low malignant potential . A complete surgical resection can achieve a favorable prognosis.…”

Section: Introductionmentioning

confidence: 99%

Enucleation of solid pseudopapillary tumor with a preoperative nasopancreatic drainage stent in a child

Tanaka

Misawa

Haruki

et al. 2017

Asian J Endoscop Surgery

View full text Add to dashboard Cite

Solid pseudopapillary tumor (SPT) is a rare pancreatic tumor with low-grade malignancy in children. A complete surgical resection can achieve a favorable prognosis. Although several reports have indicated that enucleation is considered a safe and effective treatment, the most significant complication is injury to the main pancreatic duct. The usefulness and safety of tumor enucleation after preoperative placement of an endoscopic nasopancreatic drainage stent (NPDS) has recently been reported. We present the case of SPT in a 10-year-old girl. To avoid and detect injury to the main pancreatic duct during operation, an NPDS was endoscopically placed before laparotomy. The patient underwent a complete enucleation of the tumor with the guidance of an NPDS. Our case is the first report of a successful enucleation of an SPT with a preoperative placement of an NPDS. This procedure may lead to safe enucleation of a pancreatic tumor with low malignancy, such as SPT, in children.

show abstract

Solid pseudopapillary tumor of the pancreas in male patients: Report of 16 cases

Abstract: Male patients with SPT of the pancreas are older than female patients. There are no significant differences between male and female patients regarding surgical strategies and prognosis.

Cited by 47 publications

References 0 publications

Solid-Pseudopapillary Tumor of the Pancreas: A Single Center Experience

Solid-Pseudopapillary Tumor of the Pancreas: A Single Center Experience

Targeted next generation sequencing of pancreatic solid pseudopapillary neoplasms show mutations in Wnt signaling pathway genes

Enucleation of solid pseudopapillary tumor with a preoperative nasopancreatic drainage stent in a child

Contact Info

Product

Resources

About