Solid Pseudopapillary Neoplasms of the Pancreas: A Multi-Institutional Study of 21 Patients

Matos, Jesus M.; Grützmann, Robert; Agaram, Narasimhan P.; Saeger, Hans‐Detlev; Kumar, Hari R.; Lillemoe, Keith D.; Schmidt, C. Max

doi:10.1016/j.jss.2009.03.091

Cited by 47 publications

(31 citation statements)

References 22 publications

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“…The multifaceted nature of the tumor has been shown by immunohistochemical staining. SPNs have been found to be positive for CD56, α-1-antitrypsin, CD10, NSE, progesterone receptor and vimentin [44]. They have been found to be negative for chromogranin A and synaptophysin, thus essentially ruling out a neuroendocrine origin [43].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas at a Single Institution

Suzuki¹,

Hatori²,

Furukawa

et al. 2014

Dig Surg

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Aims: The aim of this study was to determine the clinicopathological features and surgical management of solid pseudopapillary neoplasms (SPNs) of the pancreas at a single institution. Methods: We investigated 34 patients (5 males and 29 females) who underwent surgery for pathologically confirmed SPNs between 1994 and 2012. Results: Clinical symptoms were absent in 58.8% of the patients. The median tumor diameter was 42.7 mm. All tumors were successfully removed by R0 resection. Pathologically, 5.9% had duodenum invasion and 2.9% had pancreatic serosal invasion, but there was no lymph node metastasis. Radiological findings showed calcification in 39.4% of the patients, capsule formation in 51.5%, cystic components in 69.7%, solid components in 93.9% and internal bleeding in 36.4%. Immunohistochemically, neuron-specific enolase was positive in 100% of the patients, nuclear accumulation of β-catenin in 100% and CD10 in 78.8%. There were no recurrences reported at the median follow-up (67 months). Regarding gender differences, the cystic component in radiological imaging was the only significant finding among the features studied (p = 0.01). Conclusions: R0 resection with appropriate procedures appears to be sufficient for patients with SPNs, even for locally invasive tumors. There were no significant differences between genders except for the cystic component on radiological imaging.

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Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas at a Single Institution

Suzuki¹,

Hatori²,

Furukawa

et al. 2014

Dig Surg

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“…Pain and abdominal mass or fullness is reported as most common symptoms 13 . A study reported abdominal pain as frequent as 67%, back pain 10%, weight loss 10%, nausea and vomiting 10% and diarrhoea five percent 16 . Less frequent symptoms include jaundice, gastrointestinal obstruction, anaemia and pancreatitis 17 .…”

Section: Discussionmentioning

confidence: 98%

“…However, its role for malignancy is reported to be less than 10% and long term results are still awaited 24 . Laparoscopic surgery may be a reasonable option for SPN of pancreas due to their low malignant potential and younger population of patient 16,24 . Surgical resection is the main stay of therapy.…”

Section: Discussionmentioning

confidence: 99%

Solid pseudopapillary neoplasm of the pancreas

Bohara

Sharma

et al. 2014

J. Kathmandu Med. Coll.

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Solid Pseudopapillary Neoplasm (SPN) of pancreas is atypical and uncommon pancreatic neoplasm which accounts for less than one percent of all pancreatic tumours. It is more common in females but has also been described in males. It has distinct radiological and histological features. Surgical resection is the mainstay of treatment.We report two cases of pancreatic neoplasm which were revealed as pseudopapillary tumour on histopathology report and both of the patients are doing well in follow up.

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“…Bei MCN wird ab einer Tumorgröße von 3 cm die Empfehlung zur Resektion gegeben [8]. SPN sollten immer reseziert werden, da sie trotz ihrer malignen Eigenschaften mit sehr guten Heilungschancen verbunden sind [33]. Bei den IPMN ist die klinische Situation komplexer.…”

Section: Therapeutisches Vorgehenunclassified

Zystische Tumoren des Pankreas

Grützmann

Saeger

2010

Chirurg

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Cysts of the pancreas most often develop after chronic or acute inflammation of the pancreas. Cystic neoplasia of the pancreas have been increasingly recognized in clinical practice and 90% are represented by four types: serous microcystic (SCN), mucinous cystic (MCN), intraductal papillary-mucinous (IPMN) and solid pseudopapillary (SPN) neoplasia. IPMN is the most common form nowadays and main duct and branch duct types can be differentiated by morphology. This classification is of prognostic and therapeutic relevance. While main duct IPMNs have a high risk of malignant progression and resection is therefore recommended, branch duct IPMNs have a much lower risk of harboring malignancy. Small branch duct IPMNs (<2 cm) without symptoms or mural nodules can be managed by periodic surveillance. Recently, it has become clear that IPMN constitutes a heterogeneous group with at least four subtypes. Their stratification reveals that the various subtypes of IPMN have different biological properties with different prognostic implications, but the subclassification is usually not known prior to surgery. Moreover, even differentiation between inflammatory and neoplastic cysts can be challenging. Clear indications for resection are local complications (jaundice or gastric outlet obstruction), large and increasing tumors, symptoms or secretion of mucinous fluid from the papilla of Vater.

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Solid Pseudopapillary Neoplasms of the Pancreas: A Multi-Institutional Study of 21 Patients

Cited by 47 publications

References 22 publications

Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas at a Single Institution

Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas at a Single Institution

Solid pseudopapillary neoplasm of the pancreas

Zystische Tumoren des Pankreas

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