Solid-phase synthesis of peptides with azopyridine side-chains for Mn(i)–CO binding and red-light responsive CO release

Abstract

Photoactivatable carbon monoxide-releasing molecules (photoCORMs) have provided a unique opportunity for the manipulation of the highly toxic but physiologically-relevant CO gas. Here we describe an operationally-simple and efficient one-pot solid-phase...

Metal-based carbon monoxide releasing molecules with promising cytotoxic properties

“…The kCO and t1/2 values of 24g are (1.8 ± 0.5) × 10−2 s−1 and 39 ± 10 s, respectively. 184 Please do not adjust margins Please do not adjust margins…”

Recent advances in carbon monoxide-releasing nanomaterials

“…In 2022, Chunmao He and colleagues employed the solid-phase synthesis strategy to successfully synthesize a series of linear or cyclic peptides featuring azopyridine (azpy) side chains for efficient Mn–CO binding [ 90 ]. These Mn–CO-azopyridines encompassed light-responsive peptide motifs capable of CO release upon red light stimulation while preserving the inherent characteristics of the peptides.…”